Neuropsychological Function in Manic-Depressive Psychosis Evidence for Persistent Deficits in Patients with Chronic, Severe Illness
While neuropsychological deficits are recognised to occur in manic-depressive psychosis during episodes of depression and to reverse with clinical recovery, it is uncertain whether they can ever be seen outside episodes of illness. Forty-five patients meeting DSM-III-R criteria for major depression...
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| Veröffentlicht in: | British journal of psychiatry 1995-07, Vol.167 (1), p.51-57 |
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| creator | McKay, A. P. Tarbuck, A. F. Shapleske, J. McKenna, P. J. |
| description | While neuropsychological deficits are recognised to occur in manic-depressive psychosis during episodes of depression and to reverse with clinical recovery, it is uncertain whether they can ever be seen outside episodes of illness.
Forty-five patients meeting DSM-III-R criteria for major depression or bipolar disorder were screened using tests of memory, executive function and overall intellectual function. All testing was carried out during remission of affective symptoms.
None of 24 young patients and 11 elderly patients scored in the impaired range on any of the tests. However, five of ten patients with chronic, severe affective disorder were impaired on one or more of the measures. On more detailed neuropsychological investigation, these five patients were found to show a variable pattern of impairment, ranging from memory and executive deficits in relative isolation, to widespread poor performance.
Enduring neuropsychological deficits may be a feature of chronic, severe manic-depressive illness. |
| doi_str_mv | 10.1192/bjp.167.1.51 |
| format | Article |
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Forty-five patients meeting DSM-III-R criteria for major depression or bipolar disorder were screened using tests of memory, executive function and overall intellectual function. All testing was carried out during remission of affective symptoms.
None of 24 young patients and 11 elderly patients scored in the impaired range on any of the tests. However, five of ten patients with chronic, severe affective disorder were impaired on one or more of the measures. On more detailed neuropsychological investigation, these five patients were found to show a variable pattern of impairment, ranging from memory and executive deficits in relative isolation, to widespread poor performance.
Enduring neuropsychological deficits may be a feature of chronic, severe manic-depressive illness.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.167.1.51</identifier><identifier>PMID: 7551609</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Affective symptoms ; Aged ; Bipolar disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - psychology ; Chronic Disease ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Emotional disorders ; Executive function ; Female ; Geriatrics ; Humans ; Intelligence ; Male ; Manic depressive disorder ; Memory ; Mental depression ; Mental Recall ; Mental Status Schedule ; Middle Aged ; Neurocognitive Disorders - diagnosis ; Neurocognitive Disorders - psychology ; Neuropsychological functioning ; Neuropsychological Tests ; Neuropsychology ; Older people ; Patients ; Psychosis ; Remission ; Remission (Medicine) ; Severity ; Social isolation</subject><ispartof>British journal of psychiatry, 1995-07, Vol.167 (1), p.51-57</ispartof><rights>Copyright © 1995 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-b588232e8cdadb26d8c5c9792528a244d2c912b2b32591fdff91a017fb5774223</citedby><cites>FETCH-LOGICAL-c409t-b588232e8cdadb26d8c5c9792528a244d2c912b2b32591fdff91a017fb5774223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000063777/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12826,27903,27904,30978,30979,55606</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7551609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKay, A. P.</creatorcontrib><creatorcontrib>Tarbuck, A. F.</creatorcontrib><creatorcontrib>Shapleske, J.</creatorcontrib><creatorcontrib>McKenna, P. J.</creatorcontrib><title>Neuropsychological Function in Manic-Depressive Psychosis Evidence for Persistent Deficits in Patients with Chronic, Severe Illness</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>While neuropsychological deficits are recognised to occur in manic-depressive psychosis during episodes of depression and to reverse with clinical recovery, it is uncertain whether they can ever be seen outside episodes of illness.
Forty-five patients meeting DSM-III-R criteria for major depression or bipolar disorder were screened using tests of memory, executive function and overall intellectual function. All testing was carried out during remission of affective symptoms.
None of 24 young patients and 11 elderly patients scored in the impaired range on any of the tests. However, five of ten patients with chronic, severe affective disorder were impaired on one or more of the measures. On more detailed neuropsychological investigation, these five patients were found to show a variable pattern of impairment, ranging from memory and executive deficits in relative isolation, to widespread poor performance.
Enduring neuropsychological deficits may be a feature of chronic, severe manic-depressive illness.</description><subject>Adult</subject><subject>Affective symptoms</subject><subject>Aged</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - psychology</subject><subject>Chronic Disease</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Emotional disorders</subject><subject>Executive function</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Intelligence</subject><subject>Male</subject><subject>Manic depressive disorder</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Mental Recall</subject><subject>Mental Status Schedule</subject><subject>Middle Aged</subject><subject>Neurocognitive Disorders - diagnosis</subject><subject>Neurocognitive Disorders - psychology</subject><subject>Neuropsychological functioning</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Older people</subject><subject>Patients</subject><subject>Psychosis</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Severity</subject><subject>Social isolation</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhxhXJEhKnJvVHHMdHtG2hUikrAWfLcSYbr7JxsJOteuaP4-2uWoSQOFmeefzMWC9CbynJKVXsvN6MOS1lTnNBn6EFLSTLaFGK52hBCJEZZYK8RK9i3KQrL5g8QSdSCFoStUC_bmEOfoz3tvO9Xztrenw1D3ZyfsBuwF_M4Gx2AWOAGN0O8OoBjS7iy51rYLCAWx_wCkKqTTBM-AJaZ90U989XZnKpFvGdmzq87IJPujP8DXYQAF_3_ZC0r9GL1vQR3hzPU_Tj6vL78nN28_XT9fLjTWYLoqasFlXFOIPKNqapWdlUVlglFROsMqwoGmYVZTWrOROKtk3bKmoIlW0tpCwY46fow8E7Bv9zhjjprYsW-t4M4OeopSy5klL9FxSylIQTmcD3f4EbP4chfUIzzitSEl7tdWcHygYfY4BWj8FtTbjXlOh9hDpFqFOEmmpBE_7uKJ3rLTSP8DGz1MeHfufW3Z0LoIN9CPBPRX6caLZ1cM0anhb758zf7jGybg</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>McKay, A. 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P. ; Tarbuck, A. F. ; Shapleske, J. ; McKenna, P. 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Forty-five patients meeting DSM-III-R criteria for major depression or bipolar disorder were screened using tests of memory, executive function and overall intellectual function. All testing was carried out during remission of affective symptoms.
None of 24 young patients and 11 elderly patients scored in the impaired range on any of the tests. However, five of ten patients with chronic, severe affective disorder were impaired on one or more of the measures. On more detailed neuropsychological investigation, these five patients were found to show a variable pattern of impairment, ranging from memory and executive deficits in relative isolation, to widespread poor performance.
Enduring neuropsychological deficits may be a feature of chronic, severe manic-depressive illness.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>7551609</pmid><doi>10.1192/bjp.167.1.51</doi><tpages>7</tpages></addata></record> |
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| ispartof | British journal of psychiatry, 1995-07, Vol.167 (1), p.51-57 |
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| subjects | Adult Affective symptoms Aged Bipolar disorder Bipolar Disorder - diagnosis Bipolar Disorder - psychology Chronic Disease Depressive Disorder - diagnosis Depressive Disorder - psychology Emotional disorders Executive function Female Geriatrics Humans Intelligence Male Manic depressive disorder Memory Mental depression Mental Recall Mental Status Schedule Middle Aged Neurocognitive Disorders - diagnosis Neurocognitive Disorders - psychology Neuropsychological functioning Neuropsychological Tests Neuropsychology Older people Patients Psychosis Remission Remission (Medicine) Severity Social isolation |
| title | Neuropsychological Function in Manic-Depressive Psychosis Evidence for Persistent Deficits in Patients with Chronic, Severe Illness |
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