Increased fetoplacental active renin production in pregnancy-induced hypertension
Since pregnancy-induced hypertension is associated with impaired uteroplacental blood flow, we studied fetoplacental and maternal renin production in controls and subjects with pregnancy-induced hypertension. We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1987-08, Vol.157 (2), p.363-367 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Brar, Harbinder S. Kjos, Siri L. Dougherty, William Do, Yung-Shun Tam, Helen B. Hsueh, Willa A. |
| description | Since pregnancy-induced hypertension is associated with impaired uteroplacental blood flow, we studied fetoplacental and maternal renin production in controls and subjects with pregnancy-induced hypertension. We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and venous blood, and chorion homogenate in eight normotensive term patients and 18 patients with pregnancy-induced hypertension. No differences in active or prorenin were found in maternal blood from normal women or patients with pregnancy-induced hypertension. In contrast, fetal artery and vein, as well as chorionic tissue, contained significantly higher active renin in pregnancy-induced hypertension compared with normal subjects. No difference in fetal or chorionic prorenin was seen in the two groups. Thus active to total renin ratio was higher in the fetus and chorion of subjects with pregnancy-induced hypertension, which suggests enhanced active renin production. These results suggest that pregnancy-induced hypertension is associated with increased activity of the renin-angiotensin system in the fetoplacental unit, which is not reflected in the maternal circulation. This may be an attempt by the fetus and chorionic membranes to maintain vascular homeostasis in the face of altered uteroplacental blood flow. |
| doi_str_mv | 10.1016/S0002-9378(87)80173-4 |
| format | Article |
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We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and venous blood, and chorion homogenate in eight normotensive term patients and 18 patients with pregnancy-induced hypertension. No differences in active or prorenin were found in maternal blood from normal women or patients with pregnancy-induced hypertension. In contrast, fetal artery and vein, as well as chorionic tissue, contained significantly higher active renin in pregnancy-induced hypertension compared with normal subjects. No difference in fetal or chorionic prorenin was seen in the two groups. Thus active to total renin ratio was higher in the fetus and chorion of subjects with pregnancy-induced hypertension, which suggests enhanced active renin production. These results suggest that pregnancy-induced hypertension is associated with increased activity of the renin-angiotensin system in the fetoplacental unit, which is not reflected in the maternal circulation. This may be an attempt by the fetus and chorionic membranes to maintain vascular homeostasis in the face of altered uteroplacental blood flow.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(87)80173-4</identifier><identifier>PMID: 3303935</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Enzyme Precursors - blood ; Female ; Fetal Blood - enzymology ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension - enzymology ; Medical sciences ; Placenta - enzymology ; Pregnancy ; Pregnancy Complications, Cardiovascular - enzymology ; pregnancy-induced hypertension ; Pregnancy. Fetus. Placenta ; Renin ; Renin - blood</subject><ispartof>American journal of obstetrics and gynecology, 1987-08, Vol.157 (2), p.363-367</ispartof><rights>1987 C. V. 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We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and venous blood, and chorion homogenate in eight normotensive term patients and 18 patients with pregnancy-induced hypertension. No differences in active or prorenin were found in maternal blood from normal women or patients with pregnancy-induced hypertension. In contrast, fetal artery and vein, as well as chorionic tissue, contained significantly higher active renin in pregnancy-induced hypertension compared with normal subjects. No difference in fetal or chorionic prorenin was seen in the two groups. Thus active to total renin ratio was higher in the fetus and chorion of subjects with pregnancy-induced hypertension, which suggests enhanced active renin production. These results suggest that pregnancy-induced hypertension is associated with increased activity of the renin-angiotensin system in the fetoplacental unit, which is not reflected in the maternal circulation. This may be an attempt by the fetus and chorionic membranes to maintain vascular homeostasis in the face of altered uteroplacental blood flow.</description><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Enzyme Precursors - blood</subject><subject>Female</subject><subject>Fetal Blood - enzymology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypertension - enzymology</subject><subject>Medical sciences</subject><subject>Placenta - enzymology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - enzymology</subject><subject>pregnancy-induced hypertension</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Renin</subject><subject>Renin - blood</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KLDEQRoMoOld9BKEXIt5FX5NOJ-msRAb1CoKIug5JdbVGetJj0iPM25v5YbauQtV3KlUcQs4Y_ccok1cvlNKq1Fw1l43621CmeFnvkQmjWpWykc0-meyQI_Inpc9VWenqkBxyTrnmYkKeHwJEtAnbosNxmPcWMIy2LyyM_huLiMGHYh6HdpEbQyjWFb4HG2BZ-pDbefRjOcc4YkiZOCEHne0Tnm7fY_J2d_s6_V8-Pt0_TG8eS-CNHkstnAJLW1eDE44qUaFzzNUamOiYo62kDESDQuaopQoEAJe1ZrWWUlPJj8nF5t983NcC02hmPgH2vQ04LJJRSnJZ1TyDYgNCHFKK2Jl59DMbl4ZRs1Jp1irNypNplFmrNHWeO9suWLgZtruprbucn29zm8D2XcxKfNphStGK1Spj1xsMs4xvj9Ek8BiyNh8RRtMO_pdDfgDy_ZC4</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Brar, Harbinder S.</creator><creator>Kjos, Siri L.</creator><creator>Dougherty, William</creator><creator>Do, Yung-Shun</creator><creator>Tam, Helen B.</creator><creator>Hsueh, Willa A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870801</creationdate><title>Increased fetoplacental active renin production in pregnancy-induced hypertension</title><author>Brar, Harbinder S. ; Kjos, Siri L. ; Dougherty, William ; Do, Yung-Shun ; Tam, Helen B. ; Hsueh, Willa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-95b7ca0db4cb5b0752ebb1b49c15f1b0d601c58e56752d07c5cc3649149669063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Enzyme Precursors - blood</topic><topic>Female</topic><topic>Fetal Blood - enzymology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypertension - enzymology</topic><topic>Medical sciences</topic><topic>Placenta - enzymology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - enzymology</topic><topic>pregnancy-induced hypertension</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Renin</topic><topic>Renin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brar, Harbinder S.</creatorcontrib><creatorcontrib>Kjos, Siri L.</creatorcontrib><creatorcontrib>Dougherty, William</creatorcontrib><creatorcontrib>Do, Yung-Shun</creatorcontrib><creatorcontrib>Tam, Helen B.</creatorcontrib><creatorcontrib>Hsueh, Willa A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brar, Harbinder S.</au><au>Kjos, Siri L.</au><au>Dougherty, William</au><au>Do, Yung-Shun</au><au>Tam, Helen B.</au><au>Hsueh, Willa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased fetoplacental active renin production in pregnancy-induced hypertension</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>157</volume><issue>2</issue><spage>363</spage><epage>367</epage><pages>363-367</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Since pregnancy-induced hypertension is associated with impaired uteroplacental blood flow, we studied fetoplacental and maternal renin production in controls and subjects with pregnancy-induced hypertension. We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and venous blood, and chorion homogenate in eight normotensive term patients and 18 patients with pregnancy-induced hypertension. No differences in active or prorenin were found in maternal blood from normal women or patients with pregnancy-induced hypertension. In contrast, fetal artery and vein, as well as chorionic tissue, contained significantly higher active renin in pregnancy-induced hypertension compared with normal subjects. No difference in fetal or chorionic prorenin was seen in the two groups. Thus active to total renin ratio was higher in the fetus and chorion of subjects with pregnancy-induced hypertension, which suggests enhanced active renin production. These results suggest that pregnancy-induced hypertension is associated with increased activity of the renin-angiotensin system in the fetoplacental unit, which is not reflected in the maternal circulation. This may be an attempt by the fetus and chorionic membranes to maintain vascular homeostasis in the face of altered uteroplacental blood flow.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>3303935</pmid><doi>10.1016/S0002-9378(87)80173-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1987-08, Vol.157 (2), p.363-367 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Diseases of mother, fetus and pregnancy Enzyme Precursors - blood Female Fetal Blood - enzymology Gynecology. Andrology. Obstetrics Humans Hypertension - enzymology Medical sciences Placenta - enzymology Pregnancy Pregnancy Complications, Cardiovascular - enzymology pregnancy-induced hypertension Pregnancy. Fetus. Placenta Renin Renin - blood |
| title | Increased fetoplacental active renin production in pregnancy-induced hypertension |
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