gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity

New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of numerous compounds has permitted the determinatio...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-08, Vol.30 (8), p.1426-1433
Hauptverfasser:	Nguyen Lan Mong, Niesor, Eric, Bentzen, Craig L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena Chemistry Cholesterol, HDL - blood Diphosphonates - chemical synthesis Diphosphonates - pharmacology Exact sciences and technology Lipoproteins, HDL - blood Male Organic chemistry Organometalloidal and organometallic compounds P derivatives Phosphates - chemical synthesis Phosphates - pharmacology Preparations and properties Rats Rats, Inbred Strains Structure-Activity Relationship
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