Influence of adrenal demedullation on stress-related behaviour in Wistar rats
The influence of adrenal demedullation on stress-related behaviour (chronic immobilization) was investigated in respect to the following parameters and physiological processes: number of animals surviving the exposure, blood pressure behaviour, endogenous opioid system, pain sensitivity, endogenous...
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| Veröffentlicht in: | Pharmazie 1987-04, Vol.42 (4), p.253-255 |
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| creator | ROSKE, I RATHSACK, R NIEBER, K HILSE, H OEHME, P |
| description | The influence of adrenal demedullation on stress-related behaviour (chronic immobilization) was investigated in respect to the following parameters and physiological processes: number of animals surviving the exposure, blood pressure behaviour, endogenous opioid system, pain sensitivity, endogenous level of substance P (SP) in pituitary and hypothalamus. The results showed that chronic immobilization stress and adrenal demedullation induce the same direction of alterations of physiological processes and parameters. This fact suggests the involvement of common regulatory mechanisms both in demedullation and chronic stress. An important process in this respect may be the induction of functional insufficiency of the adrenal medulla especially concerning the adrenal peptidergic mechanisms. Contrary to the sham operated rats the demedullated animals showed differences in their stress-related behaviour of parameters of adaptive regulatory processes. In rats with demedullation either no additional stress-related alterations of parameters in relation to the general adaptation processes were induced or the demedullation-induced alterations were antagonized partially or completely by chronic immobilization. |
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The results showed that chronic immobilization stress and adrenal demedullation induce the same direction of alterations of physiological processes and parameters. This fact suggests the involvement of common regulatory mechanisms both in demedullation and chronic stress. An important process in this respect may be the induction of functional insufficiency of the adrenal medulla especially concerning the adrenal peptidergic mechanisms. Contrary to the sham operated rats the demedullated animals showed differences in their stress-related behaviour of parameters of adaptive regulatory processes. In rats with demedullation either no additional stress-related alterations of parameters in relation to the general adaptation processes were induced or the demedullation-induced alterations were antagonized partially or completely by chronic immobilization.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 2441422</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi</publisher><subject>Adrenal Medulla - physiology ; Adrenals. Interrenals ; Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Blood Pressure ; Body Weight ; Endorphins - physiology ; Fundamental and applied biological sciences. Psychology ; Hypothalamus - metabolism ; Hypothalamus - physiology ; Morphology. Functional localizations ; Pituitary Gland - metabolism ; Pituitary Gland - physiology ; Rats ; Rats, Inbred Strains ; Stress, Psychological - physiopathology ; Substance P - metabolism ; Vertebrates: endocrinology</subject><ispartof>Pharmazie, 1987-04, Vol.42 (4), p.253-255</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7583325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2441422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSKE, I</creatorcontrib><creatorcontrib>RATHSACK, R</creatorcontrib><creatorcontrib>NIEBER, K</creatorcontrib><creatorcontrib>HILSE, H</creatorcontrib><creatorcontrib>OEHME, P</creatorcontrib><title>Influence of adrenal demedullation on stress-related behaviour in Wistar rats</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>The influence of adrenal demedullation on stress-related behaviour (chronic immobilization) was investigated in respect to the following parameters and physiological processes: number of animals surviving the exposure, blood pressure behaviour, endogenous opioid system, pain sensitivity, endogenous level of substance P (SP) in pituitary and hypothalamus. The results showed that chronic immobilization stress and adrenal demedullation induce the same direction of alterations of physiological processes and parameters. This fact suggests the involvement of common regulatory mechanisms both in demedullation and chronic stress. An important process in this respect may be the induction of functional insufficiency of the adrenal medulla especially concerning the adrenal peptidergic mechanisms. Contrary to the sham operated rats the demedullated animals showed differences in their stress-related behaviour of parameters of adaptive regulatory processes. In rats with demedullation either no additional stress-related alterations of parameters in relation to the general adaptation processes were induced or the demedullation-induced alterations were antagonized partially or completely by chronic immobilization.</description><subject>Adrenal Medulla - physiology</subject><subject>Adrenals. Interrenals</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Endorphins - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus - physiology</subject><subject>Morphology. Functional localizations</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary Gland - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stress, Psychological - physiopathology</subject><subject>Substance P - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01LxDAQhnNQ1nX1Jwg5iLdCkkna7lEWPxZWvCgey2wywUg3XZNW8N8bsQgDA_M-DO9zwpZCgKwaqfUZO8_5QwhVq7pdsIXSWmqlluxpG30_UbTEB8_RJYrYc0cHclPf4xiGyMvkMVHOVaJyIsf39I5fYZgSD5G_hTxi4gnHfMFOPfaZLue9Yq_3dy-bx2r3_LDd3O6qowIzVmCMXBvvnENtZNvaFmxNJJtSSlpS4AiMWgsFrURBYIGs9LZ4oPdoalixm7-_xzR8TpTH7hCypVI40jDlrmlqEEr_glczOO2LUndM4YDpu5v9S34955gt9j5htCH_Y41pAZSBH0UTYqQ</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>ROSKE, I</creator><creator>RATHSACK, R</creator><creator>NIEBER, K</creator><creator>HILSE, H</creator><creator>OEHME, P</creator><general>Govi</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19870401</creationdate><title>Influence of adrenal demedullation on stress-related behaviour in Wistar rats</title><author>ROSKE, I ; RATHSACK, R ; NIEBER, K ; HILSE, H ; OEHME, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-355195fddda45188c83c6ee174141ce23de352902381a0e3c3ec1fc144affa563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adrenal Medulla - physiology</topic><topic>Adrenals. Interrenals</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Weight</topic><topic>Endorphins - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>Morphology. Functional localizations</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary Gland - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stress, Psychological - physiopathology</topic><topic>Substance P - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSKE, I</creatorcontrib><creatorcontrib>RATHSACK, R</creatorcontrib><creatorcontrib>NIEBER, K</creatorcontrib><creatorcontrib>HILSE, H</creatorcontrib><creatorcontrib>OEHME, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSKE, I</au><au>RATHSACK, R</au><au>NIEBER, K</au><au>HILSE, H</au><au>OEHME, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of adrenal demedullation on stress-related behaviour in Wistar rats</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>42</volume><issue>4</issue><spage>253</spage><epage>255</epage><pages>253-255</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>The influence of adrenal demedullation on stress-related behaviour (chronic immobilization) was investigated in respect to the following parameters and physiological processes: number of animals surviving the exposure, blood pressure behaviour, endogenous opioid system, pain sensitivity, endogenous level of substance P (SP) in pituitary and hypothalamus. The results showed that chronic immobilization stress and adrenal demedullation induce the same direction of alterations of physiological processes and parameters. This fact suggests the involvement of common regulatory mechanisms both in demedullation and chronic stress. An important process in this respect may be the induction of functional insufficiency of the adrenal medulla especially concerning the adrenal peptidergic mechanisms. Contrary to the sham operated rats the demedullated animals showed differences in their stress-related behaviour of parameters of adaptive regulatory processes. In rats with demedullation either no additional stress-related alterations of parameters in relation to the general adaptation processes were induced or the demedullation-induced alterations were antagonized partially or completely by chronic immobilization.</abstract><cop>Eschborn</cop><pub>Govi</pub><pmid>2441422</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Pharmazie, 1987-04, Vol.42 (4), p.253-255 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenal Medulla - physiology Adrenals. Interrenals Animals Behavior, Animal - physiology Biological and medical sciences Blood Pressure Body Weight Endorphins - physiology Fundamental and applied biological sciences. Psychology Hypothalamus - metabolism Hypothalamus - physiology Morphology. Functional localizations Pituitary Gland - metabolism Pituitary Gland - physiology Rats Rats, Inbred Strains Stress, Psychological - physiopathology Substance P - metabolism Vertebrates: endocrinology |
| title | Influence of adrenal demedullation on stress-related behaviour in Wistar rats |
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