COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1989): I. SUSCEPTIBILITY DISTRIBUTION
The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 1,032 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1989 to May 1990. Of the above total bacterial isolates, Gram-positive bacteria accoun...
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| Veröffentlicht in: | Japanese journal of antibiotics 1995/09/25, Vol.48(9), pp.1131-1160 |
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| creator | KUMAMOTO, YOSHIAKI HIROSE, TAKAOKI TANAKA, NORIAKI HIKICHI, YOSHINAO SHIGETA, SHIRO SHIRAIWA, YASUO KAMEOK, HIROSHI YOSHIDA, HIROSHI OGATA, MASAHIRO TAZAKI, HIROSHI IRI, HISAMI UCHIDA, HIROSHI KOBAYASHI, YOSHIO MATSUDA, SEIJI KITAGAWA, RYUICHI FUJIME, MAKOTO FUJITA, KAZUHIKO IGARI, JUN OGURI, TOYOKO KOSAKAI, NOZOMU YAMAGUCHI, KEIZO MOCHIDA, CHIKAKO FURUSAWA, TARO TAKEUCHI, YASUKO MORIYAMA, HIROMI SHIBATA, KIKUTARO YONEZU, SEIBUN TAKAHA, MINATO MATSUMIYA, KIYOMI TANAKA, MICHIO KAKU, MITSUO SUGAWARA, KAZUYUKI |
| description | The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 1,032 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1989 to May 1990. Of the above total bacterial isolates, Gram-positive bacteria accounted for 30.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 69.2% and most of them were Escherichia coli. 1.Enterococcus faecalis Imipenem (IPM) sho wed the highest activity against E. faecalis isolated from patients with urinary tract infections. The followings, ampicillin (ABPC) and vancomycin (VCM) showed potent activities, with the MIC90s of 2μg/ml. Piperacillin (PIPC), minocycline (MINO) and chloramphenicol (CP) were also active with the MIC90s of 8 μg/ml. The others were not so active with the MIC90s of 32 μg/ml or above. 2.Staphylococcus aureus VCM showed the high est activity against S. aureus with the MIC90 of 1μg/ml. Dicloxacillin (MDIPC) and arbekacin (ABK) were active with the MIC90s of 2μg/ml. MINO showed the MIC90 of 4μg/ml. All other agents except ciprofloxacin (CPFX) showed lower activity. 3.Staphylococcus epidermidis MINO showed the highest activity against S. epidermidis. Its MIC90 was 0.25μg/ml. The followings, ABK and VCM were also active with the MIC90s of 0.5μg/ml, 2μg/ml, respectively. The others except CPFX were not so active. 4. Coagulase-negative staphylococci (CNS) Most of the agents were active against CNS. IPM, ABK and MINO showed the highest activities with the MIC90s of 0.125μg/ml or below. MDIPC, cefazolin (CEZ), cefotiam (CTM) and VCM were also active with the MIC90s of 1μg/ml. Clindamycin (CLDM) showed lower activity, with the MIC90 of 128μg/ml. 5.Streptococcus agalactiae CEZ, cefuzonam (CZO N), IPM and CLDM showed the potent activity, all strains were inhibited at the MIC of 0.125μg/ml or below. The followings, cefmenoxime (CMX) and erythromycin (EM) were active with the MIC90s of 0.125μg/ml or below. PIPC and VCM were also active with the MIC90s 0.25μg/ml and 0.5μg/ml, respectively. Amikacin (AMK) showed lower activity. 6.Escherichia coli IPM, CTM, fl omoxef (FMOX), CMX, carumonam (CRMN), norfloxacin (NFLX), ofloxacin (OFLX) and CPFX showed the highest activities against E. coli. The MIC90s of them were 0.125μg/ml or below. Ceftazidime (CAZ) and CZON were also active with the MIC90s of 0.25μg/mi. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32μg/ml or ab |
| doi_str_mv | 10.11553/antibiotics1968b.48.1131 |
| format | Article |
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SUSCEPTIBILITY DISTRIBUTION</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>KUMAMOTO, YOSHIAKI ; HIROSE, TAKAOKI ; TANAKA, NORIAKI ; HIKICHI, YOSHINAO ; SHIGETA, SHIRO ; SHIRAIWA, YASUO ; KAMEOK, HIROSHI ; YOSHIDA, HIROSHI ; OGATA, MASAHIRO ; TAZAKI, HIROSHI ; IRI, HISAMI ; UCHIDA, HIROSHI ; KOBAYASHI, YOSHIO ; MATSUDA, SEIJI ; KITAGAWA, RYUICHI ; FUJIME, MAKOTO ; FUJITA, KAZUHIKO ; IGARI, JUN ; OGURI, TOYOKO ; KOSAKAI, NOZOMU ; YAMAGUCHI, KEIZO ; MOCHIDA, CHIKAKO ; FURUSAWA, TARO ; TAKEUCHI, YASUKO ; MORIYAMA, HIROMI ; SHIBATA, KIKUTARO ; YONEZU, SEIBUN ; TAKAHA, MINATO ; MATSUMIYA, KIYOMI ; TANAKA, MICHIO ; KAKU, MITSUO ; SUGAWARA, KAZUYUKI</creator><creatorcontrib>KUMAMOTO, YOSHIAKI ; HIROSE, TAKAOKI ; TANAKA, NORIAKI ; HIKICHI, YOSHINAO ; SHIGETA, SHIRO ; SHIRAIWA, YASUO ; KAMEOK, HIROSHI ; YOSHIDA, HIROSHI ; OGATA, MASAHIRO ; TAZAKI, HIROSHI ; IRI, HISAMI ; UCHIDA, HIROSHI ; KOBAYASHI, YOSHIO ; MATSUDA, SEIJI ; KITAGAWA, RYUICHI ; FUJIME, MAKOTO ; FUJITA, KAZUHIKO ; IGARI, JUN ; OGURI, TOYOKO ; KOSAKAI, NOZOMU ; YAMAGUCHI, KEIZO ; MOCHIDA, CHIKAKO ; FURUSAWA, TARO ; TAKEUCHI, YASUKO ; MORIYAMA, HIROMI ; SHIBATA, KIKUTARO ; YONEZU, SEIBUN ; TAKAHA, MINATO ; MATSUMIYA, KIYOMI ; TANAKA, MICHIO ; KAKU, MITSUO ; SUGAWARA, KAZUYUKI</creatorcontrib><description>The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 1,032 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1989 to May 1990. Of the above total bacterial isolates, Gram-positive bacteria accounted for 30.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 69.2% and most of them were Escherichia coli. 1.Enterococcus faecalis Imipenem (IPM) sho wed the highest activity against E. faecalis isolated from patients with urinary tract infections. The followings, ampicillin (ABPC) and vancomycin (VCM) showed potent activities, with the MIC90s of 2μg/ml. Piperacillin (PIPC), minocycline (MINO) and chloramphenicol (CP) were also active with the MIC90s of 8 μg/ml. The others were not so active with the MIC90s of 32 μg/ml or above. 2.Staphylococcus aureus VCM showed the high est activity against S. aureus with the MIC90 of 1μg/ml. Dicloxacillin (MDIPC) and arbekacin (ABK) were active with the MIC90s of 2μg/ml. MINO showed the MIC90 of 4μg/ml. All other agents except ciprofloxacin (CPFX) showed lower activity. 3.Staphylococcus epidermidis MINO showed the highest activity against S. epidermidis. Its MIC90 was 0.25μg/ml. The followings, ABK and VCM were also active with the MIC90s of 0.5μg/ml, 2μg/ml, respectively. The others except CPFX were not so active. 4. Coagulase-negative staphylococci (CNS) Most of the agents were active against CNS. IPM, ABK and MINO showed the highest activities with the MIC90s of 0.125μg/ml or below. MDIPC, cefazolin (CEZ), cefotiam (CTM) and VCM were also active with the MIC90s of 1μg/ml. Clindamycin (CLDM) showed lower activity, with the MIC90 of 128μg/ml. 5.Streptococcus agalactiae CEZ, cefuzonam (CZO N), IPM and CLDM showed the potent activity, all strains were inhibited at the MIC of 0.125μg/ml or below. The followings, cefmenoxime (CMX) and erythromycin (EM) were active with the MIC90s of 0.125μg/ml or below. PIPC and VCM were also active with the MIC90s 0.25μg/ml and 0.5μg/ml, respectively. Amikacin (AMK) showed lower activity. 6.Escherichia coli IPM, CTM, fl omoxef (FMOX), CMX, carumonam (CRMN), norfloxacin (NFLX), ofloxacin (OFLX) and CPFX showed the highest activities against E. coli. The MIC90s of them were 0.125μg/ml or below. Ceftazidime (CAZ) and CZON were also active with the MIC90s of 0.25μg/mi. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32μg/ml or above. 7.Klebsiella pneumoniae FMOX, CMX, cefixime (CFIX), IPM, CRMN and NFLX showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125μg/ml or below. CZON and OFLX were also active with the MIC90s of 0.25μg/ml. Penicillins except MPC showed lower activities. All other agents were active with the MIC90s of 4μg/ml or below. 8.Enterobacter cloacae IPM and OFLX showed the highest activities against E. cloacae. The MIC90s of them were 0.25μg/ml. The followings, gentamicin (GM) and NFLX were active with the MIC90s of 0.5μg/ml. Penicillins and cephems generally showed lower activities. 9.Proteus mirabilis Most of the agents were active against P.mirabilis. Cephems were generally active with the MIC90s in a range of ≤0.125μg/ml-4μg/ml. CRMN, NFLX and CPFX were active with the MIC90s of 0.125μg/ml or below. However MPC and MINO were not so active with the MIC90s of 32 fig/mi.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.48.1131</identifier><identifier>PMID: 7474333</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents, Urinary - pharmacology ; Bacteria - drug effects ; Bacteria - isolation & purification ; Bacterial Infections - microbiology ; Enterobacter cloacae - drug effects ; Enterococcus faecalis - drug effects ; Escherichia coli - drug effects ; Humans ; Klebsiella pneumoniae - drug effects ; Microbial Sensitivity Tests ; Proteus mirabilis - drug effects ; Pseudomonas aeruginosa - drug effects ; Serratia marcescens - drug effects ; Staphylococcus - drug effects ; Streptococcus agalactiae - drug effects ; Urinary Tract Infections - microbiology</subject><ispartof>The Japanese Journal of Antibiotics, 1995/09/25, Vol.48(9), pp.1131-1160</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7474333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUMAMOTO, YOSHIAKI</creatorcontrib><creatorcontrib>HIROSE, TAKAOKI</creatorcontrib><creatorcontrib>TANAKA, NORIAKI</creatorcontrib><creatorcontrib>HIKICHI, YOSHINAO</creatorcontrib><creatorcontrib>SHIGETA, SHIRO</creatorcontrib><creatorcontrib>SHIRAIWA, YASUO</creatorcontrib><creatorcontrib>KAMEOK, HIROSHI</creatorcontrib><creatorcontrib>YOSHIDA, HIROSHI</creatorcontrib><creatorcontrib>OGATA, MASAHIRO</creatorcontrib><creatorcontrib>TAZAKI, HIROSHI</creatorcontrib><creatorcontrib>IRI, HISAMI</creatorcontrib><creatorcontrib>UCHIDA, HIROSHI</creatorcontrib><creatorcontrib>KOBAYASHI, YOSHIO</creatorcontrib><creatorcontrib>MATSUDA, SEIJI</creatorcontrib><creatorcontrib>KITAGAWA, RYUICHI</creatorcontrib><creatorcontrib>FUJIME, MAKOTO</creatorcontrib><creatorcontrib>FUJITA, KAZUHIKO</creatorcontrib><creatorcontrib>IGARI, JUN</creatorcontrib><creatorcontrib>OGURI, TOYOKO</creatorcontrib><creatorcontrib>KOSAKAI, NOZOMU</creatorcontrib><creatorcontrib>YAMAGUCHI, KEIZO</creatorcontrib><creatorcontrib>MOCHIDA, CHIKAKO</creatorcontrib><creatorcontrib>FURUSAWA, TARO</creatorcontrib><creatorcontrib>TAKEUCHI, YASUKO</creatorcontrib><creatorcontrib>MORIYAMA, HIROMI</creatorcontrib><creatorcontrib>SHIBATA, KIKUTARO</creatorcontrib><creatorcontrib>YONEZU, SEIBUN</creatorcontrib><creatorcontrib>TAKAHA, MINATO</creatorcontrib><creatorcontrib>MATSUMIYA, KIYOMI</creatorcontrib><creatorcontrib>TANAKA, MICHIO</creatorcontrib><creatorcontrib>KAKU, MITSUO</creatorcontrib><creatorcontrib>SUGAWARA, KAZUYUKI</creatorcontrib><title>COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1989): I. SUSCEPTIBILITY DISTRIBUTION</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 1,032 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1989 to May 1990. Of the above total bacterial isolates, Gram-positive bacteria accounted for 30.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 69.2% and most of them were Escherichia coli. 1.Enterococcus faecalis Imipenem (IPM) sho wed the highest activity against E. faecalis isolated from patients with urinary tract infections. The followings, ampicillin (ABPC) and vancomycin (VCM) showed potent activities, with the MIC90s of 2μg/ml. Piperacillin (PIPC), minocycline (MINO) and chloramphenicol (CP) were also active with the MIC90s of 8 μg/ml. The others were not so active with the MIC90s of 32 μg/ml or above. 2.Staphylococcus aureus VCM showed the high est activity against S. aureus with the MIC90 of 1μg/ml. Dicloxacillin (MDIPC) and arbekacin (ABK) were active with the MIC90s of 2μg/ml. MINO showed the MIC90 of 4μg/ml. All other agents except ciprofloxacin (CPFX) showed lower activity. 3.Staphylococcus epidermidis MINO showed the highest activity against S. epidermidis. Its MIC90 was 0.25μg/ml. The followings, ABK and VCM were also active with the MIC90s of 0.5μg/ml, 2μg/ml, respectively. The others except CPFX were not so active. 4. Coagulase-negative staphylococci (CNS) Most of the agents were active against CNS. IPM, ABK and MINO showed the highest activities with the MIC90s of 0.125μg/ml or below. MDIPC, cefazolin (CEZ), cefotiam (CTM) and VCM were also active with the MIC90s of 1μg/ml. Clindamycin (CLDM) showed lower activity, with the MIC90 of 128μg/ml. 5.Streptococcus agalactiae CEZ, cefuzonam (CZO N), IPM and CLDM showed the potent activity, all strains were inhibited at the MIC of 0.125μg/ml or below. The followings, cefmenoxime (CMX) and erythromycin (EM) were active with the MIC90s of 0.125μg/ml or below. PIPC and VCM were also active with the MIC90s 0.25μg/ml and 0.5μg/ml, respectively. Amikacin (AMK) showed lower activity. 6.Escherichia coli IPM, CTM, fl omoxef (FMOX), CMX, carumonam (CRMN), norfloxacin (NFLX), ofloxacin (OFLX) and CPFX showed the highest activities against E. coli. The MIC90s of them were 0.125μg/ml or below. Ceftazidime (CAZ) and CZON were also active with the MIC90s of 0.25μg/mi. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32μg/ml or above. 7.Klebsiella pneumoniae FMOX, CMX, cefixime (CFIX), IPM, CRMN and NFLX showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125μg/ml or below. CZON and OFLX were also active with the MIC90s of 0.25μg/ml. Penicillins except MPC showed lower activities. All other agents were active with the MIC90s of 4μg/ml or below. 8.Enterobacter cloacae IPM and OFLX showed the highest activities against E. cloacae. The MIC90s of them were 0.25μg/ml. The followings, gentamicin (GM) and NFLX were active with the MIC90s of 0.5μg/ml. Penicillins and cephems generally showed lower activities. 9.Proteus mirabilis Most of the agents were active against P.mirabilis. Cephems were generally active with the MIC90s in a range of ≤0.125μg/ml-4μg/ml. CRMN, NFLX and CPFX were active with the MIC90s of 0.125μg/ml or below. However MPC and MINO were not so active with the MIC90s of 32 fig/mi.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents, Urinary - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial Infections - microbiology</subject><subject>Enterobacter cloacae - drug effects</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Humans</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Proteus mirabilis - drug effects</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Serratia marcescens - drug effects</subject><subject>Staphylococcus - drug effects</subject><subject>Streptococcus agalactiae - drug effects</subject><subject>Urinary Tract Infections - microbiology</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu2zAQRYkiRWqk-YQC7CZIF0rEh_hYMorsErGlQqQLdCVQEtUq8COR5EXX-fEwtZFFNzOYuXfOYi4AX1F8g1CSkFu3m_q63099MyLJRH1DRVAI-gBmGAkWJZTzMzCLCRMR5gJ9Apfj2NcxQVzggDgH55xySgiZgZe0WP1QpbL6ZwaNXd_rzMAihyoNG23_TXOocqtXOi2LO62WUC2y3JrQlM6Nhalam-N9US5Urs3KQG2KpbLZPZyXxQquS52r8he0ZcBCnc-zQC9yA6-RFPLbZ_Cxc5vRX576BVjPM5t-j5bFQqdqGT0iIadI4kYiEtdtzETXSemopK4jhDZdUrcNY7HgGLeOYSKxkwx53LSkYYLymCYdJxfg6sh9GvbPBz9O1bYfG7_ZuJ3fH8aKc4YpliIYv5yMh3rr2-pp6Ldu-Fudvhb0h6P-OE7ut3_X3RAy2fjq_4AqKir5Vt5Senc1f9xQ-R15BWmYg54</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>KUMAMOTO, YOSHIAKI</creator><creator>HIROSE, TAKAOKI</creator><creator>TANAKA, NORIAKI</creator><creator>HIKICHI, YOSHINAO</creator><creator>SHIGETA, SHIRO</creator><creator>SHIRAIWA, YASUO</creator><creator>KAMEOK, HIROSHI</creator><creator>YOSHIDA, HIROSHI</creator><creator>OGATA, MASAHIRO</creator><creator>TAZAKI, HIROSHI</creator><creator>IRI, HISAMI</creator><creator>UCHIDA, HIROSHI</creator><creator>KOBAYASHI, YOSHIO</creator><creator>MATSUDA, SEIJI</creator><creator>KITAGAWA, RYUICHI</creator><creator>FUJIME, MAKOTO</creator><creator>FUJITA, KAZUHIKO</creator><creator>IGARI, JUN</creator><creator>OGURI, TOYOKO</creator><creator>KOSAKAI, NOZOMU</creator><creator>YAMAGUCHI, KEIZO</creator><creator>MOCHIDA, CHIKAKO</creator><creator>FURUSAWA, TARO</creator><creator>TAKEUCHI, YASUKO</creator><creator>MORIYAMA, HIROMI</creator><creator>SHIBATA, KIKUTARO</creator><creator>YONEZU, SEIBUN</creator><creator>TAKAHA, MINATO</creator><creator>MATSUMIYA, KIYOMI</creator><creator>TANAKA, MICHIO</creator><creator>KAKU, MITSUO</creator><creator>SUGAWARA, KAZUYUKI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199509</creationdate><title>COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1989)</title><author>KUMAMOTO, YOSHIAKI ; HIROSE, TAKAOKI ; TANAKA, NORIAKI ; HIKICHI, YOSHINAO ; SHIGETA, SHIRO ; SHIRAIWA, YASUO ; KAMEOK, HIROSHI ; YOSHIDA, HIROSHI ; OGATA, MASAHIRO ; TAZAKI, HIROSHI ; IRI, HISAMI ; UCHIDA, HIROSHI ; KOBAYASHI, YOSHIO ; MATSUDA, SEIJI ; KITAGAWA, RYUICHI ; FUJIME, MAKOTO ; FUJITA, KAZUHIKO ; IGARI, JUN ; OGURI, TOYOKO ; KOSAKAI, NOZOMU ; YAMAGUCHI, KEIZO ; MOCHIDA, CHIKAKO ; FURUSAWA, TARO ; TAKEUCHI, YASUKO ; MORIYAMA, HIROMI ; SHIBATA, KIKUTARO ; YONEZU, SEIBUN ; TAKAHA, MINATO ; MATSUMIYA, KIYOMI ; TANAKA, MICHIO ; KAKU, MITSUO ; SUGAWARA, KAZUYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j189t-92c9130bd068ff99a494af334cf5bdc6608722da62392a961e2cd3c6847045f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1995</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Infective Agents, Urinary - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial Infections - microbiology</topic><topic>Enterobacter cloacae - drug effects</topic><topic>Enterococcus faecalis - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Humans</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Proteus mirabilis - drug effects</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Serratia marcescens - drug effects</topic><topic>Staphylococcus - drug effects</topic><topic>Streptococcus agalactiae - drug effects</topic><topic>Urinary Tract Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUMAMOTO, YOSHIAKI</creatorcontrib><creatorcontrib>HIROSE, TAKAOKI</creatorcontrib><creatorcontrib>TANAKA, NORIAKI</creatorcontrib><creatorcontrib>HIKICHI, YOSHINAO</creatorcontrib><creatorcontrib>SHIGETA, SHIRO</creatorcontrib><creatorcontrib>SHIRAIWA, YASUO</creatorcontrib><creatorcontrib>KAMEOK, HIROSHI</creatorcontrib><creatorcontrib>YOSHIDA, HIROSHI</creatorcontrib><creatorcontrib>OGATA, MASAHIRO</creatorcontrib><creatorcontrib>TAZAKI, HIROSHI</creatorcontrib><creatorcontrib>IRI, HISAMI</creatorcontrib><creatorcontrib>UCHIDA, HIROSHI</creatorcontrib><creatorcontrib>KOBAYASHI, YOSHIO</creatorcontrib><creatorcontrib>MATSUDA, SEIJI</creatorcontrib><creatorcontrib>KITAGAWA, RYUICHI</creatorcontrib><creatorcontrib>FUJIME, MAKOTO</creatorcontrib><creatorcontrib>FUJITA, KAZUHIKO</creatorcontrib><creatorcontrib>IGARI, JUN</creatorcontrib><creatorcontrib>OGURI, TOYOKO</creatorcontrib><creatorcontrib>KOSAKAI, NOZOMU</creatorcontrib><creatorcontrib>YAMAGUCHI, KEIZO</creatorcontrib><creatorcontrib>MOCHIDA, CHIKAKO</creatorcontrib><creatorcontrib>FURUSAWA, TARO</creatorcontrib><creatorcontrib>TAKEUCHI, YASUKO</creatorcontrib><creatorcontrib>MORIYAMA, HIROMI</creatorcontrib><creatorcontrib>SHIBATA, KIKUTARO</creatorcontrib><creatorcontrib>YONEZU, SEIBUN</creatorcontrib><creatorcontrib>TAKAHA, MINATO</creatorcontrib><creatorcontrib>MATSUMIYA, KIYOMI</creatorcontrib><creatorcontrib>TANAKA, MICHIO</creatorcontrib><creatorcontrib>KAKU, MITSUO</creatorcontrib><creatorcontrib>SUGAWARA, KAZUYUKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUMAMOTO, YOSHIAKI</au><au>HIROSE, TAKAOKI</au><au>TANAKA, NORIAKI</au><au>HIKICHI, YOSHINAO</au><au>SHIGETA, SHIRO</au><au>SHIRAIWA, YASUO</au><au>KAMEOK, HIROSHI</au><au>YOSHIDA, HIROSHI</au><au>OGATA, MASAHIRO</au><au>TAZAKI, HIROSHI</au><au>IRI, HISAMI</au><au>UCHIDA, HIROSHI</au><au>KOBAYASHI, YOSHIO</au><au>MATSUDA, SEIJI</au><au>KITAGAWA, RYUICHI</au><au>FUJIME, MAKOTO</au><au>FUJITA, KAZUHIKO</au><au>IGARI, JUN</au><au>OGURI, TOYOKO</au><au>KOSAKAI, NOZOMU</au><au>YAMAGUCHI, KEIZO</au><au>MOCHIDA, CHIKAKO</au><au>FURUSAWA, TARO</au><au>TAKEUCHI, YASUKO</au><au>MORIYAMA, HIROMI</au><au>SHIBATA, KIKUTARO</au><au>YONEZU, SEIBUN</au><au>TAKAHA, MINATO</au><au>MATSUMIYA, KIYOMI</au><au>TANAKA, MICHIO</au><au>KAKU, MITSUO</au><au>SUGAWARA, KAZUYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1989): I. SUSCEPTIBILITY DISTRIBUTION</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1995-09</date><risdate>1995</risdate><volume>48</volume><issue>9</issue><spage>1131</spage><epage>1160</epage><pages>1131-1160</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 1,032 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1989 to May 1990. Of the above total bacterial isolates, Gram-positive bacteria accounted for 30.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 69.2% and most of them were Escherichia coli. 1.Enterococcus faecalis Imipenem (IPM) sho wed the highest activity against E. faecalis isolated from patients with urinary tract infections. The followings, ampicillin (ABPC) and vancomycin (VCM) showed potent activities, with the MIC90s of 2μg/ml. Piperacillin (PIPC), minocycline (MINO) and chloramphenicol (CP) were also active with the MIC90s of 8 μg/ml. The others were not so active with the MIC90s of 32 μg/ml or above. 2.Staphylococcus aureus VCM showed the high est activity against S. aureus with the MIC90 of 1μg/ml. Dicloxacillin (MDIPC) and arbekacin (ABK) were active with the MIC90s of 2μg/ml. MINO showed the MIC90 of 4μg/ml. All other agents except ciprofloxacin (CPFX) showed lower activity. 3.Staphylococcus epidermidis MINO showed the highest activity against S. epidermidis. Its MIC90 was 0.25μg/ml. The followings, ABK and VCM were also active with the MIC90s of 0.5μg/ml, 2μg/ml, respectively. The others except CPFX were not so active. 4. Coagulase-negative staphylococci (CNS) Most of the agents were active against CNS. IPM, ABK and MINO showed the highest activities with the MIC90s of 0.125μg/ml or below. MDIPC, cefazolin (CEZ), cefotiam (CTM) and VCM were also active with the MIC90s of 1μg/ml. Clindamycin (CLDM) showed lower activity, with the MIC90 of 128μg/ml. 5.Streptococcus agalactiae CEZ, cefuzonam (CZO N), IPM and CLDM showed the potent activity, all strains were inhibited at the MIC of 0.125μg/ml or below. The followings, cefmenoxime (CMX) and erythromycin (EM) were active with the MIC90s of 0.125μg/ml or below. PIPC and VCM were also active with the MIC90s 0.25μg/ml and 0.5μg/ml, respectively. Amikacin (AMK) showed lower activity. 6.Escherichia coli IPM, CTM, fl omoxef (FMOX), CMX, carumonam (CRMN), norfloxacin (NFLX), ofloxacin (OFLX) and CPFX showed the highest activities against E. coli. The MIC90s of them were 0.125μg/ml or below. Ceftazidime (CAZ) and CZON were also active with the MIC90s of 0.25μg/mi. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32μg/ml or above. 7.Klebsiella pneumoniae FMOX, CMX, cefixime (CFIX), IPM, CRMN and NFLX showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125μg/ml or below. CZON and OFLX were also active with the MIC90s of 0.25μg/ml. Penicillins except MPC showed lower activities. All other agents were active with the MIC90s of 4μg/ml or below. 8.Enterobacter cloacae IPM and OFLX showed the highest activities against E. cloacae. The MIC90s of them were 0.25μg/ml. The followings, gentamicin (GM) and NFLX were active with the MIC90s of 0.5μg/ml. Penicillins and cephems generally showed lower activities. 9.Proteus mirabilis Most of the agents were active against P.mirabilis. Cephems were generally active with the MIC90s in a range of ≤0.125μg/ml-4μg/ml. CRMN, NFLX and CPFX were active with the MIC90s of 0.125μg/ml or below. However MPC and MINO were not so active with the MIC90s of 32 fig/mi.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>7474333</pmid><doi>10.11553/antibiotics1968b.48.1131</doi><tpages>30</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1995/09/25, Vol.48(9), pp.1131-1160 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - pharmacology Anti-Infective Agents, Urinary - pharmacology Bacteria - drug effects Bacteria - isolation & purification Bacterial Infections - microbiology Enterobacter cloacae - drug effects Enterococcus faecalis - drug effects Escherichia coli - drug effects Humans Klebsiella pneumoniae - drug effects Microbial Sensitivity Tests Proteus mirabilis - drug effects Pseudomonas aeruginosa - drug effects Serratia marcescens - drug effects Staphylococcus - drug effects Streptococcus agalactiae - drug effects Urinary Tract Infections - microbiology |
| title | COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1989): I. SUSCEPTIBILITY DISTRIBUTION |
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