Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation ( lpr ) mutation is a leaky mutation in Fas . By means of gene targeting, we generated a mouse strain which i...
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| Veröffentlicht in: | Nature genetics 1995-11, Vol.11 (3), p.294-300 |
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| container_title | Nature genetics |
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| creator | Adachi, Masashi Suematsu, Sachiko Kondo, Toru Ogasawara, Jun Tanaka, Takashi Yoshida, Nobuaki Nagata, Shigekazu |
| description | Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (
lpr
) mutation is a leaky mutation in
Fas
. By means of gene targeting, we generated a mouse strain which is completely deficient in
Fas
. In addition to the massive production of lymphocytes, the
Fas
–null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs. |
| doi_str_mv | 10.1038/ng1195-294 |
| format | Article |
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lpr
) mutation is a leaky mutation in
Fas
. By means of gene targeting, we generated a mouse strain which is completely deficient in
Fas
. In addition to the massive production of lymphocytes, the
Fas
–null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1195-294</identifier><identifier>PMID: 7581453</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animal Genetics and Genomics ; Animals ; Apoptosis ; Base Sequence ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Classical genetics, quantitative genetics, hybrids ; Embryo, Mammalian - cytology ; fas Receptor - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Gene Function ; Gene Targeting ; Genetics of eukaryotes. Biological and molecular evolution ; Human Genetics ; Hyperplasia - genetics ; Liver - cytology ; Liver - pathology ; Lymph Nodes - pathology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Molecular Sequence Data ; Mutation ; Spleen - pathology ; Stem Cells ; Vertebrata</subject><ispartof>Nature genetics, 1995-11, Vol.11 (3), p.294-300</ispartof><rights>Springer Nature America, Inc. 1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-a74b1c9e7d2a531f273006abeef79d40ef683bea0a5fbe9a230e1c493a7972753</citedby><cites>FETCH-LOGICAL-c469t-a74b1c9e7d2a531f273006abeef79d40ef683bea0a5fbe9a230e1c493a7972753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng1195-294$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng1195-294$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2896519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7581453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Masashi</creatorcontrib><creatorcontrib>Suematsu, Sachiko</creatorcontrib><creatorcontrib>Kondo, Toru</creatorcontrib><creatorcontrib>Ogasawara, Jun</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Yoshida, Nobuaki</creatorcontrib><creatorcontrib>Nagata, Shigekazu</creatorcontrib><title>Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (
lpr
) mutation is a leaky mutation in
Fas
. By means of gene targeting, we generated a mouse strain which is completely deficient in
Fas
. In addition to the massive production of lymphocytes, the
Fas
–null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Embryo, Mammalian - cytology</subject><subject>fas Receptor - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Gene Function</subject><subject>Gene Targeting</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human Genetics</subject><subject>Hyperplasia - genetics</subject><subject>Liver - cytology</subject><subject>Liver - pathology</subject><subject>Lymph Nodes - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Transgenic</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Spleen - pathology</subject><subject>Stem Cells</subject><subject>Vertebrata</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktr3TAQRkVpSfPadF_QomTR4FRvWcsQmgcEukl2BTO2x74KtuxIduD--_jiy82m0NVo-A7fwEGEfOPsijOZ_wot505nwqlP5JhrZTJuef55eTPDM8Wk-UpOUnphjCvF8iNyZHXOlZbH5O8TxBYnrGk_TzD5IVAf6LRBeguJthiQVjAnTHSzHTGOHSQPO2RZ_LjBCB3ttv24GXxNh9hCSBRCTTv_hvGMfGmgS3i-n6fk-fb308199vjn7uHm-jGrlHFTBlaVvHJoawFa8kZYyZiBErGxrlYMG5PLEoGBbkp0ICRDXiknwTorrJan5GLtHePwOmOait6nCrsOAg5zKqw1QjjH_gtybYwwzi3gzxWs4pBSxKYYo-8hbgvOip3zYnVeLM4X-Pu-dS57rA_oXvKS_9jnkCromgih8umAidwZzXc3L1csLUloMRYvwxzDIu7fR-lKB5jmiIe2j78g3wEeBKJk</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Adachi, Masashi</creator><creator>Suematsu, Sachiko</creator><creator>Kondo, Toru</creator><creator>Ogasawara, Jun</creator><creator>Tanaka, Takashi</creator><creator>Yoshida, Nobuaki</creator><creator>Nagata, Shigekazu</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver</title><author>Adachi, Masashi ; Suematsu, Sachiko ; Kondo, Toru ; Ogasawara, Jun ; Tanaka, Takashi ; Yoshida, Nobuaki ; Nagata, Shigekazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-a74b1c9e7d2a531f273006abeef79d40ef683bea0a5fbe9a230e1c493a7972753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Embryo, Mammalian - cytology</topic><topic>fas Receptor - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Gene Function</topic><topic>Gene Targeting</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human Genetics</topic><topic>Hyperplasia - genetics</topic><topic>Liver - cytology</topic><topic>Liver - pathology</topic><topic>Lymph Nodes - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Transgenic</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Spleen - pathology</topic><topic>Stem Cells</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adachi, Masashi</creatorcontrib><creatorcontrib>Suematsu, Sachiko</creatorcontrib><creatorcontrib>Kondo, Toru</creatorcontrib><creatorcontrib>Ogasawara, Jun</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Yoshida, Nobuaki</creatorcontrib><creatorcontrib>Nagata, Shigekazu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adachi, Masashi</au><au>Suematsu, Sachiko</au><au>Kondo, Toru</au><au>Ogasawara, Jun</au><au>Tanaka, Takashi</au><au>Yoshida, Nobuaki</au><au>Nagata, Shigekazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>11</volume><issue>3</issue><spage>294</spage><epage>300</epage><pages>294-300</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (
lpr
) mutation is a leaky mutation in
Fas
. By means of gene targeting, we generated a mouse strain which is completely deficient in
Fas
. In addition to the massive production of lymphocytes, the
Fas
–null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>7581453</pmid><doi>10.1038/ng1195-294</doi><tpages>7</tpages></addata></record> |
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| subjects | Agriculture Animal Genetics and Genomics Animals Apoptosis Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids Embryo, Mammalian - cytology fas Receptor - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Function Gene Targeting Genetics of eukaryotes. Biological and molecular evolution Human Genetics Hyperplasia - genetics Liver - cytology Liver - pathology Lymph Nodes - pathology Mice Mice, Inbred BALB C Mice, Transgenic Molecular Sequence Data Mutation Spleen - pathology Stem Cells Vertebrata |
| title | Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver |
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