Multiple modes of ligand recognition: Crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

Cyclin‐dependent kinases (CDKs) are conserved regulators of the eukaryotic cell cycle with different isoforms controlling specific phases of the cell cycle. Mitogenic or growth inhibitory signals are mediated, respectively, by activation or inhibition of CDKs which phosphorylate proteins associated...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 1995-08, Vol.22 (4), p.378-391
Hauptverfasser:	Schulze-Gahmen, Ursula, Brandsen, Jeroen, Jones, Heather D., Morgan, David O., Meijer, Laurent, Vesely, Jaroslav, Kim, Sung-Hou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemistry Adenosine Triphosphate - chemistry Amino Acid Sequence cancer CDC2-CDC28 Kinases CDK inhibitor specificity Crystallography, X-Ray Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - chemistry drug design Enzyme Inhibitors - chemistry Humans Isopentenyladenosine Kinetin Ligands Models, Molecular Molecular Conformation Molecular Sequence Data protein kinase inhibitors Protein Kinases - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - chemistry Purines - chemistry Surface Properties X-ray crystallography
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