HRE 664, A NEW PARENTERAL PENEM: I. ANTIBACTERIAL ACTIVITY IN VITRO

The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Grampositive aerobes and anaerobes. With an MIC 90% of 0.43 μg/ml, it is also active against methicillin-resistant staphyloco...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1987/05/25, Vol.40(5), pp.660-667
Hauptverfasser:	SEIBERT, G., ISERT, D., KLESEL, N., LIMBERT, M., PRIES, A., SCHRINNER, E., COOKE, M., WALMSLEY, J., BENTLEY, P. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria, Aerobic - drug effects Bacteria, Anaerobic - drug effects beta-Lactamases - metabolism beta-Lactams Biological and medical sciences Enterobacteriaceae - drug effects Lactams Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Grampositive aerobes and anaerobes. With an MIC 90% of 0.43 μg/ml, it is also active against methicillin-resistant staphylococci. HRE 664 is extremely stable against β-lactamases, it binds preferentially to the penicillin-binding proteins 2, 3, 5 and 6 of Escherichia coli.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.40.660