The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model
OBJECTIVE: Our purpose was to investigate pressure changes induced by angiotensin II on placental vasculature pretreated with atrial natriuretic factor. STUDY DESIGN: A dual-perfused cotyledon model was used. Two cytoledons from each placenta were perfused. One cotyledon was infused with atrial natr...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1995-10, Vol.173 (4), p.1143-1147 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Markenson, Glenn R. Foley, Katherine Maslow, Arthur S. Kopelman, Jerome N. |
| description | OBJECTIVE: Our purpose was to investigate pressure changes induced by angiotensin II on placental vasculature pretreated with atrial natriuretic factor.
STUDY DESIGN: A dual-perfused cotyledon model was used. Two cytoledons from each placenta were perfused. One cotyledon was infused with atrial natriuretic factor for 30 minutes while the other received an equal volume of saline solution. Three atrial natriuretic factor concentrations were studied: 50 pg/ml, 150 pg/ml, and 15 ng/ml. Both cotyledons received injections of angiotensin II, at the following doses: 1 × 10
−11.5, 1 × 10
−11, 1 × 10
−10.5, and 1 × 10
−10 mol.
RESULTS: Cotyledons subjected to 50 pg/ml and 150 pg/ml concentrations of atrial natriuretic factor did not differ in pressure responses to angiotensin II, compared with the saline-infused cotyledons (
p > 0.05). The 15 ng/ml concentration of atrial natriuretic factor, however, decreased the pressor response of angiotensin II (
p < 0.034).
CONCLUSIONS: Atrial natriuretic factor decreases vasoconstriction caused by angiotensin II. However, this was seen only at a supraphysiologic concentration. No effect was noted at normal fetal concentrations of atrial natriuretic factor. |
| doi_str_mv | 10.1016/0002-9378(95)91341-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77619304</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002937895913416</els_id><sourcerecordid>77619304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-c07b9e351db128c6288099e07deb1f62287ae06ba0bd9b929eb3cbe05f1810d53</originalsourceid><addsrcrecordid>eNp9kUuLFDEUhYMoM-3oPxghCxFdlCaprlSyEWTw0TDgZlyHPG6cSLpSk6QaZ-dPN2U3vXQRbsL57rnhXISuKXlPCeUfCCGsk_0o3srhnaT9lnb8CdpQIseOCy6eos0ZuUTPS_m1PplkF-hi3IqhJ2KD_tzdAwbvwdaCk8e65qAjnta6ZKjBYq9tTRnrybXzM6QKUwkT3u1wmrCHqmM3R21hajc8Q_ZLCU2ZM5TSLHBj6zrkNz6EQ8I21ccIrhH75CC-QM-8jgVenuoV-vHl893Nt-72-9fdzafbzvaC186S0UjoB-oMZcJyJgSREsjowFDPGROjBsKNJsZJI5kE01sDZPBUUOKG_gq9OfrOOT0sUKrah2IhRj1BWooaR05lT7YN3B5Bm1MpGbyac9jr_KgoUWvwao1RrakqOah_wSve2l6d_BezB3duOiXd9NcnXRero896sqGcsbYWIQbWsI9HDFoWhwBZFRtgsuBCbjtSLoX__-MvBYeg7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77619304</pqid></control><display><type>article</type><title>The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Markenson, Glenn R. ; Foley, Katherine ; Maslow, Arthur S. ; Kopelman, Jerome N.</creator><creatorcontrib>Markenson, Glenn R. ; Foley, Katherine ; Maslow, Arthur S. ; Kopelman, Jerome N.</creatorcontrib><description>OBJECTIVE: Our purpose was to investigate pressure changes induced by angiotensin II on placental vasculature pretreated with atrial natriuretic factor.
STUDY DESIGN: A dual-perfused cotyledon model was used. Two cytoledons from each placenta were perfused. One cotyledon was infused with atrial natriuretic factor for 30 minutes while the other received an equal volume of saline solution. Three atrial natriuretic factor concentrations were studied: 50 pg/ml, 150 pg/ml, and 15 ng/ml. Both cotyledons received injections of angiotensin II, at the following doses: 1 × 10
−11.5, 1 × 10
−11, 1 × 10
−10.5, and 1 × 10
−10 mol.
RESULTS: Cotyledons subjected to 50 pg/ml and 150 pg/ml concentrations of atrial natriuretic factor did not differ in pressure responses to angiotensin II, compared with the saline-infused cotyledons (
p > 0.05). The 15 ng/ml concentration of atrial natriuretic factor, however, decreased the pressor response of angiotensin II (
p < 0.034).
CONCLUSIONS: Atrial natriuretic factor decreases vasoconstriction caused by angiotensin II. However, this was seen only at a supraphysiologic concentration. No effect was noted at normal fetal concentrations of atrial natriuretic factor.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(95)91341-6</identifier><identifier>PMID: 7485308</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>angiotensin II ; Angiotensin II - pharmacology ; Atrial natriuretic factor ; Atrial Natriuretic Factor - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Female ; Fetus - blood supply ; Fundamental and applied biological sciences. Psychology ; Humans ; Models, Cardiovascular ; Mother. Fetoplacental unit. Mammary gland. Milk ; Placenta - blood supply ; placental perfusion ; Pregnancy ; Pregnancy. Parturition. Lactation ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - pharmacology ; Vertebrates: reproduction</subject><ispartof>American journal of obstetrics and gynecology, 1995-10, Vol.173 (4), p.1143-1147</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c07b9e351db128c6288099e07deb1f62287ae06ba0bd9b929eb3cbe05f1810d53</citedby><cites>FETCH-LOGICAL-c386t-c07b9e351db128c6288099e07deb1f62287ae06ba0bd9b929eb3cbe05f1810d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937895913416$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2928852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7485308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markenson, Glenn R.</creatorcontrib><creatorcontrib>Foley, Katherine</creatorcontrib><creatorcontrib>Maslow, Arthur S.</creatorcontrib><creatorcontrib>Kopelman, Jerome N.</creatorcontrib><title>The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: Our purpose was to investigate pressure changes induced by angiotensin II on placental vasculature pretreated with atrial natriuretic factor.
STUDY DESIGN: A dual-perfused cotyledon model was used. Two cytoledons from each placenta were perfused. One cotyledon was infused with atrial natriuretic factor for 30 minutes while the other received an equal volume of saline solution. Three atrial natriuretic factor concentrations were studied: 50 pg/ml, 150 pg/ml, and 15 ng/ml. Both cotyledons received injections of angiotensin II, at the following doses: 1 × 10
−11.5, 1 × 10
−11, 1 × 10
−10.5, and 1 × 10
−10 mol.
RESULTS: Cotyledons subjected to 50 pg/ml and 150 pg/ml concentrations of atrial natriuretic factor did not differ in pressure responses to angiotensin II, compared with the saline-infused cotyledons (
p > 0.05). The 15 ng/ml concentration of atrial natriuretic factor, however, decreased the pressor response of angiotensin II (
p < 0.034).
CONCLUSIONS: Atrial natriuretic factor decreases vasoconstriction caused by angiotensin II. However, this was seen only at a supraphysiologic concentration. No effect was noted at normal fetal concentrations of atrial natriuretic factor.</description><subject>angiotensin II</subject><subject>Angiotensin II - pharmacology</subject><subject>Atrial natriuretic factor</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Female</subject><subject>Fetus - blood supply</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Models, Cardiovascular</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Placenta - blood supply</subject><subject>placental perfusion</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vertebrates: reproduction</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEUhYMoM-3oPxghCxFdlCaprlSyEWTw0TDgZlyHPG6cSLpSk6QaZ-dPN2U3vXQRbsL57rnhXISuKXlPCeUfCCGsk_0o3srhnaT9lnb8CdpQIseOCy6eos0ZuUTPS_m1PplkF-hi3IqhJ2KD_tzdAwbvwdaCk8e65qAjnta6ZKjBYq9tTRnrybXzM6QKUwkT3u1wmrCHqmM3R21hajc8Q_ZLCU2ZM5TSLHBj6zrkNz6EQ8I21ccIrhH75CC-QM-8jgVenuoV-vHl893Nt-72-9fdzafbzvaC186S0UjoB-oMZcJyJgSREsjowFDPGROjBsKNJsZJI5kE01sDZPBUUOKG_gq9OfrOOT0sUKrah2IhRj1BWooaR05lT7YN3B5Bm1MpGbyac9jr_KgoUWvwao1RrakqOah_wSve2l6d_BezB3duOiXd9NcnXRero896sqGcsbYWIQbWsI9HDFoWhwBZFRtgsuBCbjtSLoX__-MvBYeg7w</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Markenson, Glenn R.</creator><creator>Foley, Katherine</creator><creator>Maslow, Arthur S.</creator><creator>Kopelman, Jerome N.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model</title><author>Markenson, Glenn R. ; Foley, Katherine ; Maslow, Arthur S. ; Kopelman, Jerome N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c07b9e351db128c6288099e07deb1f62287ae06ba0bd9b929eb3cbe05f1810d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>angiotensin II</topic><topic>Angiotensin II - pharmacology</topic><topic>Atrial natriuretic factor</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Female</topic><topic>Fetus - blood supply</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Models, Cardiovascular</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Placenta - blood supply</topic><topic>placental perfusion</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markenson, Glenn R.</creatorcontrib><creatorcontrib>Foley, Katherine</creatorcontrib><creatorcontrib>Maslow, Arthur S.</creatorcontrib><creatorcontrib>Kopelman, Jerome N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markenson, Glenn R.</au><au>Foley, Katherine</au><au>Maslow, Arthur S.</au><au>Kopelman, Jerome N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>173</volume><issue>4</issue><spage>1143</spage><epage>1147</epage><pages>1143-1147</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>OBJECTIVE: Our purpose was to investigate pressure changes induced by angiotensin II on placental vasculature pretreated with atrial natriuretic factor.
STUDY DESIGN: A dual-perfused cotyledon model was used. Two cytoledons from each placenta were perfused. One cotyledon was infused with atrial natriuretic factor for 30 minutes while the other received an equal volume of saline solution. Three atrial natriuretic factor concentrations were studied: 50 pg/ml, 150 pg/ml, and 15 ng/ml. Both cotyledons received injections of angiotensin II, at the following doses: 1 × 10
−11.5, 1 × 10
−11, 1 × 10
−10.5, and 1 × 10
−10 mol.
RESULTS: Cotyledons subjected to 50 pg/ml and 150 pg/ml concentrations of atrial natriuretic factor did not differ in pressure responses to angiotensin II, compared with the saline-infused cotyledons (
p > 0.05). The 15 ng/ml concentration of atrial natriuretic factor, however, decreased the pressor response of angiotensin II (
p < 0.034).
CONCLUSIONS: Atrial natriuretic factor decreases vasoconstriction caused by angiotensin II. However, this was seen only at a supraphysiologic concentration. No effect was noted at normal fetal concentrations of atrial natriuretic factor.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>7485308</pmid><doi>10.1016/0002-9378(95)91341-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1995-10, Vol.173 (4), p.1143-1147 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | angiotensin II Angiotensin II - pharmacology Atrial natriuretic factor Atrial Natriuretic Factor - pharmacology Biological and medical sciences Blood Pressure - drug effects Female Fetus - blood supply Fundamental and applied biological sciences. Psychology Humans Models, Cardiovascular Mother. Fetoplacental unit. Mammary gland. Milk Placenta - blood supply placental perfusion Pregnancy Pregnancy. Parturition. Lactation Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vertebrates: reproduction |
| title | The effects of atrial natriuretic factor and angiotensin II on fetal-placental perfusion pressure in the ex vivo cotyledon model |
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