Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel
The Drosophila Shaker ('Sh) gene appears to encode a type of voltage-sensitive potassium (K +) channel called the A channel. We have isolated Sh as part of a 350 kb chromosomal walk. The region around Sh contains four identified transcription units. We find that Sh corresponds to a very large t...
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| Veröffentlicht in: | Cell 1987-07, Vol.50 (3), p.405-413 |
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| container_title | Cell |
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| creator | Kamb, Alexander Iverson, Linda E. Tanouye, Mark A. |
| description | The Drosophila
Shaker ('Sh) gene appears to encode a type of voltage-sensitive potassium (K
+) channel called the A channel. We have isolated
Sh as part of a 350 kb chromosomal walk. The region around
Sh contains four identified transcription units. We find that
Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron.
Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel. |
| doi_str_mv | 10.1016/0092-8674(87)90494-6 |
| format | Article |
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Shaker ('Sh) gene appears to encode a type of voltage-sensitive potassium (K
+) channel called the A channel. We have isolated
Sh as part of a 350 kb chromosomal walk. The region around
Sh contains four identified transcription units. We find that
Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron.
Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(87)90494-6</identifier><identifier>PMID: 2440582</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Biological and medical sciences ; Cloning, Molecular ; DNA Restriction Enzymes - metabolism ; Drosophila ; Drosophila - genetics ; Drosophilidae ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes ; Genes. Genome ; Ion Channels ; Molecular and cellular biology ; Molecular genetics ; potassium ; Translocation, Genetic</subject><ispartof>Cell, 1987-07, Vol.50 (3), p.405-413</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-340f8e2149c11381608ca2396ad569c7c53fb97fe063f0bcec31033f0387c83</citedby><cites>FETCH-LOGICAL-c417t-340f8e2149c11381608ca2396ad569c7c53fb97fe063f0bcec31033f0387c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(87)90494-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7467577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2440582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamb, Alexander</creatorcontrib><creatorcontrib>Iverson, Linda E.</creatorcontrib><creatorcontrib>Tanouye, Mark A.</creatorcontrib><title>Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel</title><title>Cell</title><addtitle>Cell</addtitle><description>The Drosophila
Shaker ('Sh) gene appears to encode a type of voltage-sensitive potassium (K
+) channel called the A channel. We have isolated
Sh as part of a 350 kb chromosomal walk. The region around
Sh contains four identified transcription units. We find that
Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron.
Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.</description><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>Cloning, Molecular</subject><subject>DNA Restriction Enzymes - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophilidae</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genes. Genome</subject><subject>Ion Channels</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>potassium</subject><subject>Translocation, Genetic</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo6-zqP1Dog8gKtuar83ERZP2EFQ_rwVuoqa52oj2d2aRb0F9vxhnmqKcE3qdeqh7GHgn-QnBhXnLuZeuM1ZfOPvNce92aO2wluLetFlbeZasTcp-dl_Kdc-66rjtjZ1Jr3jm5Yl8_pZFwGSE3uIEMOFOOv2GOaWrS0Nxs4Afl5w00b3IqabeJIzTfaKJm3sDc0ISpp1LjXZqhlLhs9zXTROMDdm-AsdDD43vBbt69_XL1ob3-_P7j1evrFuuOc6s0HxxJoT0KoZww3CFI5Q30nfFosVPD2tuBuFEDXyOhElzVr3IWnbpgTw-tu5xuFypz2MaCNI4wUVpKsNYIL6X-Lyi0lV5JWUF9ALEeXDINYZfjFvKvIHjYew97qWEvNTgb_noPpo49PvYv6y31p6Gj6Jo_OeZQEMYhw4SxnDCrje2srdirA0ZV2c9IORSM1TL1MRPOoU_x33v8AaONnds</recordid><startdate>19870731</startdate><enddate>19870731</enddate><creator>Kamb, Alexander</creator><creator>Iverson, Linda E.</creator><creator>Tanouye, Mark A.</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19870731</creationdate><title>Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel</title><author>Kamb, Alexander ; Iverson, Linda E. ; Tanouye, Mark A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-340f8e2149c11381608ca2396ad569c7c53fb97fe063f0bcec31033f0387c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Cloning, Molecular</topic><topic>DNA Restriction Enzymes - metabolism</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophilidae</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genes</topic><topic>Genes. Genome</topic><topic>Ion Channels</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>potassium</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamb, Alexander</creatorcontrib><creatorcontrib>Iverson, Linda E.</creatorcontrib><creatorcontrib>Tanouye, Mark A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamb, Alexander</au><au>Iverson, Linda E.</au><au>Tanouye, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1987-07-31</date><risdate>1987</risdate><volume>50</volume><issue>3</issue><spage>405</spage><epage>413</epage><pages>405-413</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>The Drosophila
Shaker ('Sh) gene appears to encode a type of voltage-sensitive potassium (K
+) channel called the A channel. We have isolated
Sh as part of a 350 kb chromosomal walk. The region around
Sh contains four identified transcription units. We find that
Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron.
Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>2440582</pmid><doi>10.1016/0092-8674(87)90494-6</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 1987-07, Vol.50 (3), p.405-413 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77619224 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Biological and medical sciences Cloning, Molecular DNA Restriction Enzymes - metabolism Drosophila Drosophila - genetics Drosophilidae Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes. Genome Ion Channels Molecular and cellular biology Molecular genetics potassium Translocation, Genetic |
| title | Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel |
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