Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits
We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. Both antibiotics were similarly effective in reducing bacterial titers. Cefotaxime, but not chloram...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 1987-09, Vol.156 (3), p.456-462 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 462 |
|---|---|
| container_issue | 3 |
| container_start_page | 456 |
| container_title | The Journal of infectious diseases |
| container_volume | 156 |
| creator | Täuber, Martin G. Shibl, Atel M. Hackbarth, Corinne J. Larrick, James W. Sande, Merle A. |
| description | We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. Both antibiotics were similarly effective in reducing bacterial titers. Cefotaxime, but not chloramphenicol, induced a marked increase of endotoxin in CSF, from log10 1.5 ± 0.8 to log10 2.8 ± 0.7 ng/ml (P < .01). This result was associated with an increase in brain water content (405 ± 12 g of water/100 g of dry weight compared with 389 ± 8 g in untreated controls; P < .01), whereas in animals treated with chloramphenicol, brain water content was identical to controls. The cefotaxime-induced increase in endotoxin concentration and brain edema were both neutralized by polymyxin B, which binds to the lipid A moiety of endotoxin, or by a monoclonal antibody to lipid A. These results indicate that treating gram-negative bacillary meningitis with selected antibiotics induces increased endotoxin concentrations in CSF that are associated with brain edema. |
| doi_str_mv | 10.1093/infdis/156.3.456 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77618653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30134753</jstor_id><sourcerecordid>30134753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-b24e5f492f4f11681905a51645cbd59be0efbd71566ee673e2f712d8d1d6cb43</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EKkNhzwYpC8SqmdrxK1mWUfoQg5CqWaBuLL9CXTL2YHuk6V_gV-N0QlmysuRz7mefcwF4j-ASwQ6fOz8Yl84RZUu8JJS9AAtEMa8ZQ_glWEDYNDVqu-41eJPSA4SQYMZPwAnGsIG0WYDfFz475UJ2utrc2yh3j2dV703I4eB8tQpeW5-jzC74arqw0aoY0s55OVaX496Zs0p6U32Ossi9sVs5-frDzka3LbPF1idd0E7fO1npMLrqq_XO_3DZpcl7K5VyOb0FrwY5JvtuPk_B5rLfrK7r9berm9XFutYlYK5VQywdSNcMZECItaiDVFLECNXK0E5ZaAdleKmEWcs4ts3AUWNagwzTiuBT8OmI3cXwa29TFluXtB1H6W3YJ8E5Qy2j-L9GRFpCKJqI8GjUpZgU7SB2JbqMjwJBMa1JHNckyp8EFiVFGfkws_dqa83zwLyXon-cdZm0HIcovS6AvzbOCMFPL8-Yh5RD_EeBCBP-FKE-6i5le3jWZfwpSjOciuvvd4LdrtftlzsoKP4DG7u2Wg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14844514</pqid></control><display><type>article</type><title>Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Täuber, Martin G. ; Shibl, Atel M. ; Hackbarth, Corinne J. ; Larrick, James W. ; Sande, Merle A.</creator><creatorcontrib>Täuber, Martin G. ; Shibl, Atel M. ; Hackbarth, Corinne J. ; Larrick, James W. ; Sande, Merle A.</creatorcontrib><description>We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. Both antibiotics were similarly effective in reducing bacterial titers. Cefotaxime, but not chloramphenicol, induced a marked increase of endotoxin in CSF, from log10 1.5 ± 0.8 to log10 2.8 ± 0.7 ng/ml (P < .01). This result was associated with an increase in brain water content (405 ± 12 g of water/100 g of dry weight compared with 389 ± 8 g in untreated controls; P < .01), whereas in animals treated with chloramphenicol, brain water content was identical to controls. The cefotaxime-induced increase in endotoxin concentration and brain edema were both neutralized by polymyxin B, which binds to the lipid A moiety of endotoxin, or by a monoclonal antibody to lipid A. These results indicate that treating gram-negative bacillary meningitis with selected antibiotics induces increased endotoxin concentrations in CSF that are associated with brain edema.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/156.3.456</identifier><identifier>PMID: 3302052</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies ; Antibodies, Monoclonal - therapeutic use ; Biological and medical sciences ; Brain edema ; Brain Edema - etiology ; Cefotaxime - therapeutic use ; Chloramphenicol - therapeutic use ; Endotoxins ; Endotoxins - cerebrospinal fluid ; Escherichia coli ; Escherichia coli Infections - cerebrospinal fluid ; Escherichia coli Infections - complications ; Escherichia coli Infections - drug therapy ; Escherichia coli meningitis ; Infections ; Lipid A - immunology ; Lipids ; Medical sciences ; Meningitis - cerebrospinal fluid ; Meningitis - complications ; Meningitis - drug therapy ; Moisture content ; Original Articles ; Pharmacology. Drug treatments ; Pneumococcal meningitis ; Polymyxin B - therapeutic use ; Polymyxins ; Rabbits</subject><ispartof>The Journal of infectious diseases, 1987-09, Vol.156 (3), p.456-462</ispartof><rights>Copyright 1987 The University of Chicago</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b24e5f492f4f11681905a51645cbd59be0efbd71566ee673e2f712d8d1d6cb43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30134753$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30134753$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7644314$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3302052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Täuber, Martin G.</creatorcontrib><creatorcontrib>Shibl, Atel M.</creatorcontrib><creatorcontrib>Hackbarth, Corinne J.</creatorcontrib><creatorcontrib>Larrick, James W.</creatorcontrib><creatorcontrib>Sande, Merle A.</creatorcontrib><title>Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. Both antibiotics were similarly effective in reducing bacterial titers. Cefotaxime, but not chloramphenicol, induced a marked increase of endotoxin in CSF, from log10 1.5 ± 0.8 to log10 2.8 ± 0.7 ng/ml (P < .01). This result was associated with an increase in brain water content (405 ± 12 g of water/100 g of dry weight compared with 389 ± 8 g in untreated controls; P < .01), whereas in animals treated with chloramphenicol, brain water content was identical to controls. The cefotaxime-induced increase in endotoxin concentration and brain edema were both neutralized by polymyxin B, which binds to the lipid A moiety of endotoxin, or by a monoclonal antibody to lipid A. These results indicate that treating gram-negative bacillary meningitis with selected antibiotics induces increased endotoxin concentrations in CSF that are associated with brain edema.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain edema</subject><subject>Brain Edema - etiology</subject><subject>Cefotaxime - therapeutic use</subject><subject>Chloramphenicol - therapeutic use</subject><subject>Endotoxins</subject><subject>Endotoxins - cerebrospinal fluid</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - cerebrospinal fluid</subject><subject>Escherichia coli Infections - complications</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli meningitis</subject><subject>Infections</subject><subject>Lipid A - immunology</subject><subject>Lipids</subject><subject>Medical sciences</subject><subject>Meningitis - cerebrospinal fluid</subject><subject>Meningitis - complications</subject><subject>Meningitis - drug therapy</subject><subject>Moisture content</subject><subject>Original Articles</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumococcal meningitis</subject><subject>Polymyxin B - therapeutic use</subject><subject>Polymyxins</subject><subject>Rabbits</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EKkNhzwYpC8SqmdrxK1mWUfoQg5CqWaBuLL9CXTL2YHuk6V_gV-N0QlmysuRz7mefcwF4j-ASwQ6fOz8Yl84RZUu8JJS9AAtEMa8ZQ_glWEDYNDVqu-41eJPSA4SQYMZPwAnGsIG0WYDfFz475UJ2utrc2yh3j2dV703I4eB8tQpeW5-jzC74arqw0aoY0s55OVaX496Zs0p6U32Ossi9sVs5-frDzka3LbPF1idd0E7fO1npMLrqq_XO_3DZpcl7K5VyOb0FrwY5JvtuPk_B5rLfrK7r9berm9XFutYlYK5VQywdSNcMZECItaiDVFLECNXK0E5ZaAdleKmEWcs4ts3AUWNagwzTiuBT8OmI3cXwa29TFluXtB1H6W3YJ8E5Qy2j-L9GRFpCKJqI8GjUpZgU7SB2JbqMjwJBMa1JHNckyp8EFiVFGfkws_dqa83zwLyXon-cdZm0HIcovS6AvzbOCMFPL8-Yh5RD_EeBCBP-FKE-6i5le3jWZfwpSjOciuvvd4LdrtftlzsoKP4DG7u2Wg</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>Täuber, Martin G.</creator><creator>Shibl, Atel M.</creator><creator>Hackbarth, Corinne J.</creator><creator>Larrick, James W.</creator><creator>Sande, Merle A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19870901</creationdate><title>Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits</title><author>Täuber, Martin G. ; Shibl, Atel M. ; Hackbarth, Corinne J. ; Larrick, James W. ; Sande, Merle A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b24e5f492f4f11681905a51645cbd59be0efbd71566ee673e2f712d8d1d6cb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antibodies</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain edema</topic><topic>Brain Edema - etiology</topic><topic>Cefotaxime - therapeutic use</topic><topic>Chloramphenicol - therapeutic use</topic><topic>Endotoxins</topic><topic>Endotoxins - cerebrospinal fluid</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - cerebrospinal fluid</topic><topic>Escherichia coli Infections - complications</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli meningitis</topic><topic>Infections</topic><topic>Lipid A - immunology</topic><topic>Lipids</topic><topic>Medical sciences</topic><topic>Meningitis - cerebrospinal fluid</topic><topic>Meningitis - complications</topic><topic>Meningitis - drug therapy</topic><topic>Moisture content</topic><topic>Original Articles</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumococcal meningitis</topic><topic>Polymyxin B - therapeutic use</topic><topic>Polymyxins</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Täuber, Martin G.</creatorcontrib><creatorcontrib>Shibl, Atel M.</creatorcontrib><creatorcontrib>Hackbarth, Corinne J.</creatorcontrib><creatorcontrib>Larrick, James W.</creatorcontrib><creatorcontrib>Sande, Merle A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Täuber, Martin G.</au><au>Shibl, Atel M.</au><au>Hackbarth, Corinne J.</au><au>Larrick, James W.</au><au>Sande, Merle A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>156</volume><issue>3</issue><spage>456</spage><epage>462</epage><pages>456-462</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We investigated the effect of cefotaxime and chloramphenicol on endotoxin concentrations in cerebrospinal fluid (CSF) and on the development of brain edema in rabbits with Escherichia coli meningitis. Both antibiotics were similarly effective in reducing bacterial titers. Cefotaxime, but not chloramphenicol, induced a marked increase of endotoxin in CSF, from log10 1.5 ± 0.8 to log10 2.8 ± 0.7 ng/ml (P < .01). This result was associated with an increase in brain water content (405 ± 12 g of water/100 g of dry weight compared with 389 ± 8 g in untreated controls; P < .01), whereas in animals treated with chloramphenicol, brain water content was identical to controls. The cefotaxime-induced increase in endotoxin concentration and brain edema were both neutralized by polymyxin B, which binds to the lipid A moiety of endotoxin, or by a monoclonal antibody to lipid A. These results indicate that treating gram-negative bacillary meningitis with selected antibiotics induces increased endotoxin concentrations in CSF that are associated with brain edema.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3302052</pmid><doi>10.1093/infdis/156.3.456</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1987-09, Vol.156 (3), p.456-462 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77618653 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antibodies, Monoclonal - therapeutic use Biological and medical sciences Brain edema Brain Edema - etiology Cefotaxime - therapeutic use Chloramphenicol - therapeutic use Endotoxins Endotoxins - cerebrospinal fluid Escherichia coli Escherichia coli Infections - cerebrospinal fluid Escherichia coli Infections - complications Escherichia coli Infections - drug therapy Escherichia coli meningitis Infections Lipid A - immunology Lipids Medical sciences Meningitis - cerebrospinal fluid Meningitis - complications Meningitis - drug therapy Moisture content Original Articles Pharmacology. Drug treatments Pneumococcal meningitis Polymyxin B - therapeutic use Polymyxins Rabbits |
| title | Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T03%3A57%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibiotic%20Therapy,%20Endotoxin%20Concentration%20in%20Cerebrospinal%20Fluid,%20and%20Brain%20Edema%20in%20Experimental%20Escherichia%20coli%20Meningitis%20in%20Rabbits&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=T%C3%A4uber,%20Martin%20G.&rft.date=1987-09-01&rft.volume=156&rft.issue=3&rft.spage=456&rft.epage=462&rft.pages=456-462&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1093/infdis/156.3.456&rft_dat=%3Cjstor_proqu%3E30134753%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14844514&rft_id=info:pmid/3302052&rft_jstor_id=30134753&rfr_iscdi=true |