Potassium translocation and spreading depression induced by electrical stimulation of the brain
Cathodal current pulses with durations from 20 ms to 80 s were applied to the surface of rat parietal neocortex, and the strength-duration properties of the threshold stimulus for initiation of spreading depression was determined. In one series, extradural stimulation was used. In a second series, a...
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| Veröffentlicht in: | Experimental neurology 1987-08, Vol.97 (2), p.345-364 |
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| container_title | Experimental neurology |
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| creator | Reid, K.H Marrannes, R De Prins, E Wauquier, A |
| description | Cathodal current pulses with durations from 20 ms to 80 s were applied to the surface of rat parietal neocortex, and the strength-duration properties of the threshold stimulus for initiation of spreading depression was determined. In one series, extradural stimulation was used. In a second series, a liquid electrode was used, the dura was opened, and K
+-sensitive microelectrodes were used to determine the time course of extracellular K
+ concentration during and after each stimulus pulse. With the dura open, the strength-duration curve was of the form
It
0.55 = constant. With extradural stimulation, the slope of the log-log plot relating current intensity to pulse duration changed gradually as the pulse duration increased, averaging 0.63. Theoretical analysis suggests that diffusion of K
+ away from a zone of current-induced accumulation can account for these slope data. Applicability of this mechanism of K
+ accumulation to observed changes in sensitivity of neurons to repeated stimulation at subcortical sites is considered. |
| doi_str_mv | 10.1016/0014-4886(87)90095-1 |
| format | Article |
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+-sensitive microelectrodes were used to determine the time course of extracellular K
+ concentration during and after each stimulus pulse. With the dura open, the strength-duration curve was of the form
It
0.55 = constant. With extradural stimulation, the slope of the log-log plot relating current intensity to pulse duration changed gradually as the pulse duration increased, averaging 0.63. Theoretical analysis suggests that diffusion of K
+ away from a zone of current-induced accumulation can account for these slope data. Applicability of this mechanism of K
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+-sensitive microelectrodes were used to determine the time course of extracellular K
+ concentration during and after each stimulus pulse. With the dura open, the strength-duration curve was of the form
It
0.55 = constant. With extradural stimulation, the slope of the log-log plot relating current intensity to pulse duration changed gradually as the pulse duration increased, averaging 0.63. Theoretical analysis suggests that diffusion of K
+ away from a zone of current-induced accumulation can account for these slope data. Applicability of this mechanism of K
+ accumulation to observed changes in sensitivity of neurons to repeated stimulation at subcortical sites is considered.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cortical Spreading Depression</subject><subject>Electric Stimulation</subject><subject>Electrodes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Parietal Lobe - metabolism</subject><subject>Parietal Lobe - physiology</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOj7-gUIWIrqoJm3aJBtBBl8g6MJ9uE1uNdLHmLSC_96MM8xSVwmc71wOHyHHnF1yxqsrxrjIhFLVuZIXmjFdZnyLzDjTLMtFwbbJbIPskf0YP1iCRC53yW5RMZ1zNSPmZRghRj91dAzQx3awMPqhp9A7GhcBwfn-jTpM34SlwPdusuho_U2xRTsGb6GlcfTd1K6qQ0PHd6R1AN8fkp0G2ohH6_eAvN7dvs4fsqfn-8f5zVNmhcjHTOi0rELW8NIiQhoJZe0KJ9DWSmKtC1ZgVSG3hWRCl9iAlMAayDGHXBcH5Gx1dhGGzwnjaDofLbYt9DhM0UhZcSW0-hfkQgopVZlAsQJtGGIM2JhF8B2Eb8OZWfo3S7lmKdcoaX79G55qJ-v7U92h25TWwlN-us4hJm9Ncm593GCyUJXQecKuVxgmZ18eg4nWY5-8-5CcGzf4v3f8AFm_osE</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Reid, K.H</creator><creator>Marrannes, R</creator><creator>De Prins, E</creator><creator>Wauquier, A</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870801</creationdate><title>Potassium translocation and spreading depression induced by electrical stimulation of the brain</title><author>Reid, K.H ; Marrannes, R ; De Prins, E ; Wauquier, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-490946e0f15ceea427a5bd3d4ecb87eb9303e66e1c370495efa77a0fa2e2a293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cortical Spreading Depression</topic><topic>Electric Stimulation</topic><topic>Electrodes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Parietal Lobe - metabolism</topic><topic>Parietal Lobe - physiology</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reid, K.H</creatorcontrib><creatorcontrib>Marrannes, R</creatorcontrib><creatorcontrib>De Prins, E</creatorcontrib><creatorcontrib>Wauquier, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reid, K.H</au><au>Marrannes, R</au><au>De Prins, E</au><au>Wauquier, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium translocation and spreading depression induced by electrical stimulation of the brain</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>97</volume><issue>2</issue><spage>345</spage><epage>364</epage><pages>345-364</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Cathodal current pulses with durations from 20 ms to 80 s were applied to the surface of rat parietal neocortex, and the strength-duration properties of the threshold stimulus for initiation of spreading depression was determined. In one series, extradural stimulation was used. In a second series, a liquid electrode was used, the dura was opened, and K
+-sensitive microelectrodes were used to determine the time course of extracellular K
+ concentration during and after each stimulus pulse. With the dura open, the strength-duration curve was of the form
It
0.55 = constant. With extradural stimulation, the slope of the log-log plot relating current intensity to pulse duration changed gradually as the pulse duration increased, averaging 0.63. Theoretical analysis suggests that diffusion of K
+ away from a zone of current-induced accumulation can account for these slope data. Applicability of this mechanism of K
+ accumulation to observed changes in sensitivity of neurons to repeated stimulation at subcortical sites is considered.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3609218</pmid><doi>10.1016/0014-4886(87)90095-1</doi><tpages>20</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Experimental neurology, 1987-08, Vol.97 (2), p.345-364 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_77618498 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cortical Spreading Depression Electric Stimulation Electrodes Male Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Parietal Lobe - metabolism Parietal Lobe - physiology Potassium - metabolism Rats Rats, Inbred Strains |
| title | Potassium translocation and spreading depression induced by electrical stimulation of the brain |
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