Hemorrhagic shock increases gut macromolecular permeability in the rat
The effect of hemorrhagic shock on gut permeability to macromolecules was investigated using fluorescein isothiocyanate dextrans (4,300 or 73,100 daltons). These were given orally, then measured in systemic blood during hemorrhage (mean arterial pressure of 30 mmHg) and reperfusion; sham-shocked ani...
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| Veröffentlicht in: | Shock (Augusta, Ga.) Ga.), 1995-07, Vol.4 (1), p.50-55 |
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| creator | Russell, D H Barreto, J C Klemm, K Miller, T A |
| description | The effect of hemorrhagic shock on gut permeability to macromolecules was investigated using fluorescein isothiocyanate dextrans (4,300 or 73,100 daltons). These were given orally, then measured in systemic blood during hemorrhage (mean arterial pressure of 30 mmHg) and reperfusion; sham-shocked animals served as controls. Hemorrhage lasting 2 h resulted in a 5-fold increase in concentration of both tracers relative to that found in control groups. Reperfusion reduced these differences, with values approximately threefold greater than those of controls after 2 h. On a molar basis, the smaller molecule was more permeant than the larger one. This study provides evidence that hemorrhagic shock physically perturbs the normal barrier function of the mucosa, permitting very large substances in the gut lumen access to the circulation. It may further explain, at least in part, previous observations that hypovolemic shock results in bacterial translocation and endotoxemia. |
| doi_str_mv | 10.1097/00024382-199507000-00008 |
| format | Article |
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These were given orally, then measured in systemic blood during hemorrhage (mean arterial pressure of 30 mmHg) and reperfusion; sham-shocked animals served as controls. Hemorrhage lasting 2 h resulted in a 5-fold increase in concentration of both tracers relative to that found in control groups. Reperfusion reduced these differences, with values approximately threefold greater than those of controls after 2 h. On a molar basis, the smaller molecule was more permeant than the larger one. This study provides evidence that hemorrhagic shock physically perturbs the normal barrier function of the mucosa, permitting very large substances in the gut lumen access to the circulation. It may further explain, at least in part, previous observations that hypovolemic shock results in bacterial translocation and endotoxemia.</description><identifier>ISSN: 1073-2322</identifier><identifier>DOI: 10.1097/00024382-199507000-00008</identifier><identifier>PMID: 7552778</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Blood Pressure - physiology ; Blood Volume - physiology ; Dextrans - pharmacokinetics ; Disease Models, Animal ; Fluorescein-5-isothiocyanate ; Gastric Emptying - physiology ; Hematocrit ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Intestinal Mucosa - physiopathology ; Macromolecular Substances ; Male ; Permeability ; Rats ; Reperfusion ; Shock, Hemorrhagic - metabolism ; Shock, Hemorrhagic - pathology ; Shock, Hemorrhagic - physiopathology</subject><ispartof>Shock (Augusta, Ga.), 1995-07, Vol.4 (1), p.50-55</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3418-5a04229b8bcdc29563b057f3cd9e4d4c752b397dc6777af2a324beadd5959b463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7552778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, D H</creatorcontrib><creatorcontrib>Barreto, J C</creatorcontrib><creatorcontrib>Klemm, K</creatorcontrib><creatorcontrib>Miller, T A</creatorcontrib><title>Hemorrhagic shock increases gut macromolecular permeability in the rat</title><title>Shock (Augusta, Ga.)</title><addtitle>Shock</addtitle><description>The effect of hemorrhagic shock on gut permeability to macromolecules was investigated using fluorescein isothiocyanate dextrans (4,300 or 73,100 daltons). These were given orally, then measured in systemic blood during hemorrhage (mean arterial pressure of 30 mmHg) and reperfusion; sham-shocked animals served as controls. Hemorrhage lasting 2 h resulted in a 5-fold increase in concentration of both tracers relative to that found in control groups. Reperfusion reduced these differences, with values approximately threefold greater than those of controls after 2 h. On a molar basis, the smaller molecule was more permeant than the larger one. This study provides evidence that hemorrhagic shock physically perturbs the normal barrier function of the mucosa, permitting very large substances in the gut lumen access to the circulation. It may further explain, at least in part, previous observations that hypovolemic shock results in bacterial translocation and endotoxemia.</description><subject>Animals</subject><subject>Blood Pressure - physiology</subject><subject>Blood Volume - physiology</subject><subject>Dextrans - pharmacokinetics</subject><subject>Disease Models, Animal</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Gastric Emptying - physiology</subject><subject>Hematocrit</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - physiopathology</subject><subject>Macromolecular Substances</subject><subject>Male</subject><subject>Permeability</subject><subject>Rats</subject><subject>Reperfusion</subject><subject>Shock, Hemorrhagic - metabolism</subject><subject>Shock, Hemorrhagic - pathology</subject><subject>Shock, Hemorrhagic - physiopathology</subject><issn>1073-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDFPwzAQhT2ASin8BCRPbAHHjnPxiCpKK1VigdmynUsbiJtiJ0P_PaYtHU6nk967e_cRQnP2lDMFz4wxXoiKZ7lSkkEas1SsuiLTnIHIuOD8htzG-HUUKpiQCUjJAaopWSzR9yFszaZ1NG57903bnQtoIka6GQfqjQu97zt0Y2cC3WPwaGzbtcMhKemwRRrMcEeuG9NFvD_3GflcvH7Ml9n6_W01f1lnThR5lUnDCs6VrayrHVeyFJZJaISrFRZ14UBymwLWrgQA03AjeGHR1LVUUtmiFDPyeNq7D_3PiHHQvo0Ou87ssB-jBijz9BskYXUSpvQxBmz0PrTehIPOmf7Dpv-x6Qs2fcSWrA_nG6P1WF-MZ2biF_CEao4</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>Russell, D H</creator><creator>Barreto, J C</creator><creator>Klemm, K</creator><creator>Miller, T A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199507</creationdate><title>Hemorrhagic shock increases gut macromolecular permeability in the rat</title><author>Russell, D H ; Barreto, J C ; Klemm, K ; Miller, T A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3418-5a04229b8bcdc29563b057f3cd9e4d4c752b397dc6777af2a324beadd5959b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Blood Pressure - physiology</topic><topic>Blood Volume - physiology</topic><topic>Dextrans - pharmacokinetics</topic><topic>Disease Models, Animal</topic><topic>Fluorescein-5-isothiocyanate</topic><topic>Gastric Emptying - physiology</topic><topic>Hematocrit</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - physiopathology</topic><topic>Macromolecular Substances</topic><topic>Male</topic><topic>Permeability</topic><topic>Rats</topic><topic>Reperfusion</topic><topic>Shock, Hemorrhagic - metabolism</topic><topic>Shock, Hemorrhagic - pathology</topic><topic>Shock, Hemorrhagic - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russell, D H</creatorcontrib><creatorcontrib>Barreto, J C</creatorcontrib><creatorcontrib>Klemm, K</creatorcontrib><creatorcontrib>Miller, T A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Shock (Augusta, Ga.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, D H</au><au>Barreto, J C</au><au>Klemm, K</au><au>Miller, T A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemorrhagic shock increases gut macromolecular permeability in the rat</atitle><jtitle>Shock (Augusta, Ga.)</jtitle><addtitle>Shock</addtitle><date>1995-07</date><risdate>1995</risdate><volume>4</volume><issue>1</issue><spage>50</spage><epage>55</epage><pages>50-55</pages><issn>1073-2322</issn><abstract>The effect of hemorrhagic shock on gut permeability to macromolecules was investigated using fluorescein isothiocyanate dextrans (4,300 or 73,100 daltons). These were given orally, then measured in systemic blood during hemorrhage (mean arterial pressure of 30 mmHg) and reperfusion; sham-shocked animals served as controls. Hemorrhage lasting 2 h resulted in a 5-fold increase in concentration of both tracers relative to that found in control groups. Reperfusion reduced these differences, with values approximately threefold greater than those of controls after 2 h. On a molar basis, the smaller molecule was more permeant than the larger one. This study provides evidence that hemorrhagic shock physically perturbs the normal barrier function of the mucosa, permitting very large substances in the gut lumen access to the circulation. It may further explain, at least in part, previous observations that hypovolemic shock results in bacterial translocation and endotoxemia.</abstract><cop>United States</cop><pmid>7552778</pmid><doi>10.1097/00024382-199507000-00008</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Shock (Augusta, Ga.), 1995-07, Vol.4 (1), p.50-55 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Animals Blood Pressure - physiology Blood Volume - physiology Dextrans - pharmacokinetics Disease Models, Animal Fluorescein-5-isothiocyanate Gastric Emptying - physiology Hematocrit Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - physiopathology Macromolecular Substances Male Permeability Rats Reperfusion Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - pathology Shock, Hemorrhagic - physiopathology |
| title | Hemorrhagic shock increases gut macromolecular permeability in the rat |
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