Absence of vacuolar H(+)-ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjögren's syndrome

Distal renal tubular acidosis (dRTA) is a common complication of autoimmune connective tissue diseases. The underlying pathophysiology of renal tubular acidosis in these syndromes is frequently characterized by impaired hydrogen ion secretion, i.e., secretory defect dRTA. However, the precise molecu...

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Veröffentlicht in:	Journal of the American Society of Nephrology 1995-08, Vol.6 (2), p.295-301
Hauptverfasser:	DeFranco, P E, Haragsim, L, Schmitz, P G, Bastani, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Renal Tubular - complications Acidosis, Renal Tubular - enzymology Acidosis, Renal Tubular - pathology Adult Female Humans Hypokalemia - complications Hypokalemia - enzymology Kidney Tubules, Collecting - enzymology Kidney Tubules, Collecting - ultrastructure Kidney Tubules, Distal - enzymology Kidney Tubules, Distal - ultrastructure Proton-Translocating ATPases - deficiency Sjogren's Syndrome - complications Sjogren's Syndrome - enzymology
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