Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast-conserving surgery
The diagnostic value of intraoperative histologic examination of frozen sections of surgical margins and axillary lymph nodes (AX) was investigated in 95 patients with breast cancer who underwent breast‐conserving surgery. The periphery of the excised breast tissue was peeled like an orange and exam...
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| Veröffentlicht in: | Journal of surgical oncology 1995-11, Vol.60 (3), p.185-190 |
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| container_title | Journal of surgical oncology |
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| creator | Noguchi, Masakuni Minami, Masahide Earashi, Mitsuharu Taniya, Takao Miyazaki, Itsuo Mizukami, Yuji Nonomura, Akitaka |
| description | The diagnostic value of intraoperative histologic examination of frozen sections of surgical margins and axillary lymph nodes (AX) was investigated in 95 patients with breast cancer who underwent breast‐conserving surgery. The periphery of the excised breast tissue was peeled like an orange and examined histologically by frozen section. The results were compared with examination by permanent section. Evaluation of surgical margins by frozen section resulted in a diagnostic accuracy of 87%, a sensitivity of 96%, and a specificity of 84%. Enlarged or hardened AXs were sampled from the axillary pad which was derived from a complete AX dissection. Histologic examination using frozen section was performed during surgery. After the operation, the remaining AXs were removed from the axillary pad by hand dissection and histologically examined on permanent section. A diagnostic accuracy of 97%, a sensitivity of 77%, and a specificity of 100% were achieved in the diagnosis of AX involvement on frozen section. It was therefore concluded that intraoperative histologic examination of frozen sections may be useful in the determination of involvement of the surgical margins and the AXs in patients with breast cancer. © 1995 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jso.2930600309 |
| format | Article |
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The periphery of the excised breast tissue was peeled like an orange and examined histologically by frozen section. The results were compared with examination by permanent section. Evaluation of surgical margins by frozen section resulted in a diagnostic accuracy of 87%, a sensitivity of 96%, and a specificity of 84%. Enlarged or hardened AXs were sampled from the axillary pad which was derived from a complete AX dissection. Histologic examination using frozen section was performed during surgery. After the operation, the remaining AXs were removed from the axillary pad by hand dissection and histologically examined on permanent section. A diagnostic accuracy of 97%, a sensitivity of 77%, and a specificity of 100% were achieved in the diagnosis of AX involvement on frozen section. It was therefore concluded that intraoperative histologic examination of frozen sections may be useful in the determination of involvement of the surgical margins and the AXs in patients with breast cancer. © 1995 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930600309</identifier><identifier>PMID: 7475069</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Axilla ; Biological and medical sciences ; Breast - pathology ; Breast - surgery ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; breast-conserving surgery ; Carcinoma in Situ - pathology ; Carcinoma in Situ - surgery ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - surgery ; Chi-Square Distribution ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Intraoperative Period ; Lymph Node Excision ; lymph node metastases ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Sensitivity and Specificity ; surgical margins ; Tumors</subject><ispartof>Journal of surgical oncology, 1995-11, Vol.60 (3), p.185-190</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4739-3c80cac5e1de402445d8381933555a13bc561a574afd9496bf8c32d1c28b492a3</citedby><cites>FETCH-LOGICAL-c4739-3c80cac5e1de402445d8381933555a13bc561a574afd9496bf8c32d1c28b492a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.2930600309$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.2930600309$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2898340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7475069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noguchi, Masakuni</creatorcontrib><creatorcontrib>Minami, Masahide</creatorcontrib><creatorcontrib>Earashi, Mitsuharu</creatorcontrib><creatorcontrib>Taniya, Takao</creatorcontrib><creatorcontrib>Miyazaki, Itsuo</creatorcontrib><creatorcontrib>Mizukami, Yuji</creatorcontrib><creatorcontrib>Nonomura, Akitaka</creatorcontrib><title>Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast-conserving surgery</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>The diagnostic value of intraoperative histologic examination of frozen sections of surgical margins and axillary lymph nodes (AX) was investigated in 95 patients with breast cancer who underwent breast‐conserving surgery. The periphery of the excised breast tissue was peeled like an orange and examined histologically by frozen section. The results were compared with examination by permanent section. Evaluation of surgical margins by frozen section resulted in a diagnostic accuracy of 87%, a sensitivity of 96%, and a specificity of 84%. Enlarged or hardened AXs were sampled from the axillary pad which was derived from a complete AX dissection. Histologic examination using frozen section was performed during surgery. After the operation, the remaining AXs were removed from the axillary pad by hand dissection and histologically examined on permanent section. A diagnostic accuracy of 97%, a sensitivity of 77%, and a specificity of 100% were achieved in the diagnosis of AX involvement on frozen section. It was therefore concluded that intraoperative histologic examination of frozen sections may be useful in the determination of involvement of the surgical margins and the AXs in patients with breast cancer. © 1995 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Axilla</subject><subject>Biological and medical sciences</subject><subject>Breast - pathology</subject><subject>Breast - surgery</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>breast-conserving surgery</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma in Situ - surgery</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - surgery</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Lymph Node Excision</subject><subject>lymph node metastases</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>surgical margins</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EKqFw5YbkA-K2wd9eH6GiaVFFEZ8SF8vr9bYuu3bwbErz7zEkCuKEZMkez_POjF8j9JSSJSWEvbyBvGSGE0UIJ-YeWlBiVGOIae-jRQVYI7QhD9EjgBtCiDFKHKEjLbQkyixQPk9zcXkdipvjbcDXEeY85qvosQMIAFNIM84Dhk2pl27Ek6uHBNilHo_baX2NU-4DnsLsoK4IOCbclVCjxucEodzGdPVHH8r2MXowuBHCk_1-jD6fvvl0ctZcXK7OT15dNF5obhruW-Kdl4H2QRAmhOxb3lLDuZTSUd55qaiTWrihN8Kobmg9Zz31rO2EYY4foxe7uuuSf2wCzHaK4MM4uhTyBqzWikrNVAWXO9CXDFDCYNcl1jduLSX2t8O2Omz_OlwFz_aVN90U-gO-t7Tmn-_zDqpfQ3HJRzhgrDUtF6RiZof9jGPY_qepffvx8p8Rmp22fla4O2hd-W6V5lrar-9WVn1Yvf9yuvpmX_NfiEal7g</recordid><startdate>199511</startdate><enddate>199511</enddate><creator>Noguchi, Masakuni</creator><creator>Minami, Masahide</creator><creator>Earashi, Mitsuharu</creator><creator>Taniya, Takao</creator><creator>Miyazaki, Itsuo</creator><creator>Mizukami, Yuji</creator><creator>Nonomura, Akitaka</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199511</creationdate><title>Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast-conserving surgery</title><author>Noguchi, Masakuni ; Minami, Masahide ; Earashi, Mitsuharu ; Taniya, Takao ; Miyazaki, Itsuo ; Mizukami, Yuji ; Nonomura, Akitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4739-3c80cac5e1de402445d8381933555a13bc561a574afd9496bf8c32d1c28b492a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Axilla</topic><topic>Biological and medical sciences</topic><topic>Breast - pathology</topic><topic>Breast - surgery</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>breast-conserving surgery</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma in Situ - surgery</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - surgery</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Lymph Node Excision</topic><topic>lymph node metastases</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>surgical margins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noguchi, Masakuni</creatorcontrib><creatorcontrib>Minami, Masahide</creatorcontrib><creatorcontrib>Earashi, Mitsuharu</creatorcontrib><creatorcontrib>Taniya, Takao</creatorcontrib><creatorcontrib>Miyazaki, Itsuo</creatorcontrib><creatorcontrib>Mizukami, Yuji</creatorcontrib><creatorcontrib>Nonomura, Akitaka</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noguchi, Masakuni</au><au>Minami, Masahide</au><au>Earashi, Mitsuharu</au><au>Taniya, Takao</au><au>Miyazaki, Itsuo</au><au>Mizukami, Yuji</au><au>Nonomura, Akitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast-conserving surgery</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1995-11</date><risdate>1995</risdate><volume>60</volume><issue>3</issue><spage>185</spage><epage>190</epage><pages>185-190</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>The diagnostic value of intraoperative histologic examination of frozen sections of surgical margins and axillary lymph nodes (AX) was investigated in 95 patients with breast cancer who underwent breast‐conserving surgery. The periphery of the excised breast tissue was peeled like an orange and examined histologically by frozen section. The results were compared with examination by permanent section. Evaluation of surgical margins by frozen section resulted in a diagnostic accuracy of 87%, a sensitivity of 96%, and a specificity of 84%. Enlarged or hardened AXs were sampled from the axillary pad which was derived from a complete AX dissection. Histologic examination using frozen section was performed during surgery. 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| ispartof | Journal of surgical oncology, 1995-11, Vol.60 (3), p.185-190 |
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| subjects | Adult Axilla Biological and medical sciences Breast - pathology Breast - surgery Breast Neoplasms - pathology Breast Neoplasms - surgery breast-conserving surgery Carcinoma in Situ - pathology Carcinoma in Situ - surgery Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - surgery Chi-Square Distribution Female Gynecology. Andrology. Obstetrics Humans Intraoperative Period Lymph Node Excision lymph node metastases Lymph Nodes - pathology Lymphatic Metastasis Mammary gland diseases Medical sciences Middle Aged Sensitivity and Specificity surgical margins Tumors |
| title | Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast-conserving surgery |
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