Biological correlates of slow wave sleep deficits in functional psychoses: 31P-magnetic resonance spectroscopy
Deficits in slow wave sleep (SWS) are consistently seen in schizophrenia and related psychotic disorders. However, the pathophysiological significance of this finding is uncertain. In 19 patients with psychotic illness, sleep and 31P-magnetic resonance spectroscopy (MRS) studies were carried out bef...
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| Veröffentlicht in: | Psychiatry research 1995-07, Vol.57 (2), p.91-100 |
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| container_title | Psychiatry research |
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| creator | Keshavan, Matcheri S. Pettegrew, Jay W. Reynolds, Charles F. Panchalingam, Kanaga S. Montrose, Debra Miewald, Jean Kupfer, David J. |
| description | Deficits in slow wave sleep (SWS) are consistently seen in schizophrenia and related psychotic disorders. However, the pathophysiological significance of this finding is uncertain. In 19 patients with psychotic illness, sleep and
31P-magnetic resonance spectroscopy (MRS) studies were carried out before the patients began medication treatment. Polysomnographic studies were carried out on 2–3 consecutive nights. MRS studies were performed with a surface coil and a depth-resolved pulse sequence focusing on the dorsal prefrontal cortex. Phosphomonoesters were correlated with visually scored delta and Stage 4 sleep, as well as with automated delta wave counts. An inverse relation was also seen between negative symptom scores and SWS. The association between decreased brain anabolic processes (reflected by decreased PME) and decreased SWS may be related either to processes of accelerated aging or to developmentally mediated alterations in cortical synaptic pruning, postulated to underlie the pathophysiology of functional psychoses. |
| doi_str_mv | 10.1016/0165-1781(95)02669-N |
| format | Article |
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31P-magnetic resonance spectroscopy (MRS) studies were carried out before the patients began medication treatment. Polysomnographic studies were carried out on 2–3 consecutive nights. MRS studies were performed with a surface coil and a depth-resolved pulse sequence focusing on the dorsal prefrontal cortex. Phosphomonoesters were correlated with visually scored delta and Stage 4 sleep, as well as with automated delta wave counts. An inverse relation was also seen between negative symptom scores and SWS. The association between decreased brain anabolic processes (reflected by decreased PME) and decreased SWS may be related either to processes of accelerated aging or to developmentally mediated alterations in cortical synaptic pruning, postulated to underlie the pathophysiology of functional psychoses.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(95)02669-N</identifier><identifier>PMID: 7480386</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Brain Diseases - diagnosis ; Brain Diseases - physiopathology ; Depressive Disorder - complications ; Depressive Disorder - diagnosis ; Depressive Disorder - physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Magnetic resonance spectroscopy ; Male ; Phosphomonoesters ; Polysomnography ; Prefrontal cortex ; Prefrontal Cortex - physiopathology ; Psychiatric Status Rating Scales ; Psychotic Disorders - complications ; Psychotic Disorders - diagnosis ; Psychotic Disorders - physiopathology ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Sleep Stages ; Sleep Wake Disorders - etiology</subject><ispartof>Psychiatry research, 1995-07, Vol.57 (2), p.91-100</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2046-4c9309508e63448bd14df64b2dc3e3cdf4e471b0596f9bd1cfda35760fef08f13</citedby><cites>FETCH-LOGICAL-c2046-4c9309508e63448bd14df64b2dc3e3cdf4e471b0596f9bd1cfda35760fef08f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016517819502669N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7480386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keshavan, Matcheri S.</creatorcontrib><creatorcontrib>Pettegrew, Jay W.</creatorcontrib><creatorcontrib>Reynolds, Charles F.</creatorcontrib><creatorcontrib>Panchalingam, Kanaga S.</creatorcontrib><creatorcontrib>Montrose, Debra</creatorcontrib><creatorcontrib>Miewald, Jean</creatorcontrib><creatorcontrib>Kupfer, David J.</creatorcontrib><title>Biological correlates of slow wave sleep deficits in functional psychoses: 31P-magnetic resonance spectroscopy</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Deficits in slow wave sleep (SWS) are consistently seen in schizophrenia and related psychotic disorders. However, the pathophysiological significance of this finding is uncertain. In 19 patients with psychotic illness, sleep and
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The association between decreased brain anabolic processes (reflected by decreased PME) and decreased SWS may be related either to processes of accelerated aging or to developmentally mediated alterations in cortical synaptic pruning, postulated to underlie the pathophysiology of functional psychoses.</description><subject>Adult</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - physiopathology</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Male</subject><subject>Phosphomonoesters</subject><subject>Polysomnography</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - physiopathology</subject><subject>Sleep Stages</subject><subject>Sleep Wake Disorders - etiology</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OGzEUhS1UlKaBN6CSVxVdDNhjj2fcBRJEtCAhYAFra3J9nbqajKf2BJS3xyERSxbWtXTOuT8fISecnXHG1Xl-VcHrhp_q6icrldLF_QGZ8qYui5qX4guZfli-km8p_WOMlVzrCZnUsmGiUVPSX_nQhaWHtqMQYsSuHTHR4Gjqwit9bV8w_xAHatF58GOivqdu3cPoQ59DQ9rA35Aw_aKCPxardtnj6IFGTFnvIccHhDGGBGHYHJFD13YJj_d1Rp5_Xz_Nb4q7hz-388u7AkomVSFBC6Yr1qASUjYLy6V1Si5KCwIFWCdR1nzBKq2czio424qqVsyhY43jYkZ-7PoOMfxfYxrNyifArmt7DOtk6lrxKk_KRrkzQt4wRXRmiH7Vxo3hzGwxmy1Ds2VodGXeMZv7HPu-779erNB-hPZcs36x0zEf-eIxmgQeMw3rY6ZhbPCfD3gD9nGOVQ</recordid><startdate>19950728</startdate><enddate>19950728</enddate><creator>Keshavan, Matcheri S.</creator><creator>Pettegrew, Jay W.</creator><creator>Reynolds, Charles F.</creator><creator>Panchalingam, Kanaga S.</creator><creator>Montrose, Debra</creator><creator>Miewald, Jean</creator><creator>Kupfer, David J.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950728</creationdate><title>Biological correlates of slow wave sleep deficits in functional psychoses: 31P-magnetic resonance spectroscopy</title><author>Keshavan, Matcheri S. ; Pettegrew, Jay W. ; Reynolds, Charles F. ; Panchalingam, Kanaga S. ; Montrose, Debra ; Miewald, Jean ; Kupfer, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2046-4c9309508e63448bd14df64b2dc3e3cdf4e471b0596f9bd1cfda35760fef08f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Brain Diseases - diagnosis</topic><topic>Brain Diseases - physiopathology</topic><topic>Depressive Disorder - complications</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic resonance spectroscopy</topic><topic>Male</topic><topic>Phosphomonoesters</topic><topic>Polysomnography</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - physiopathology</topic><topic>Sleep Stages</topic><topic>Sleep Wake Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keshavan, Matcheri S.</creatorcontrib><creatorcontrib>Pettegrew, Jay W.</creatorcontrib><creatorcontrib>Reynolds, Charles F.</creatorcontrib><creatorcontrib>Panchalingam, Kanaga S.</creatorcontrib><creatorcontrib>Montrose, Debra</creatorcontrib><creatorcontrib>Miewald, Jean</creatorcontrib><creatorcontrib>Kupfer, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keshavan, Matcheri S.</au><au>Pettegrew, Jay W.</au><au>Reynolds, Charles F.</au><au>Panchalingam, Kanaga S.</au><au>Montrose, Debra</au><au>Miewald, Jean</au><au>Kupfer, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological correlates of slow wave sleep deficits in functional psychoses: 31P-magnetic resonance spectroscopy</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1995-07-28</date><risdate>1995</risdate><volume>57</volume><issue>2</issue><spage>91</spage><epage>100</epage><pages>91-100</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Deficits in slow wave sleep (SWS) are consistently seen in schizophrenia and related psychotic disorders. However, the pathophysiological significance of this finding is uncertain. In 19 patients with psychotic illness, sleep and
31P-magnetic resonance spectroscopy (MRS) studies were carried out before the patients began medication treatment. Polysomnographic studies were carried out on 2–3 consecutive nights. MRS studies were performed with a surface coil and a depth-resolved pulse sequence focusing on the dorsal prefrontal cortex. Phosphomonoesters were correlated with visually scored delta and Stage 4 sleep, as well as with automated delta wave counts. An inverse relation was also seen between negative symptom scores and SWS. The association between decreased brain anabolic processes (reflected by decreased PME) and decreased SWS may be related either to processes of accelerated aging or to developmentally mediated alterations in cortical synaptic pruning, postulated to underlie the pathophysiology of functional psychoses.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>7480386</pmid><doi>10.1016/0165-1781(95)02669-N</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Brain Diseases - diagnosis Brain Diseases - physiopathology Depressive Disorder - complications Depressive Disorder - diagnosis Depressive Disorder - physiopathology Female Humans Magnetic Resonance Imaging Magnetic resonance spectroscopy Male Phosphomonoesters Polysomnography Prefrontal cortex Prefrontal Cortex - physiopathology Psychiatric Status Rating Scales Psychotic Disorders - complications Psychotic Disorders - diagnosis Psychotic Disorders - physiopathology Schizophrenia Schizophrenia - complications Schizophrenia - diagnosis Schizophrenia - physiopathology Sleep Stages Sleep Wake Disorders - etiology |
| title | Biological correlates of slow wave sleep deficits in functional psychoses: 31P-magnetic resonance spectroscopy |
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