Regulation of thyrotropin-releasing hormone receptor binding and phospholipase C activation by a single GTP-binding protein

In a crude membrane preparation of rat 7315c cells, GTP was found to enhance thyrotropin-releasing hormone- (TRH) stimulated inositol triphosphate (IP3) formation with a potency of 0.97 +/- 0.1 microM. TRH stimulation of IP3 formation was inhibited by high GDP concentrations. Neither nucleotide had...

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Veröffentlicht in:	The Journal of biological chemistry 1987-07, Vol.262 (20), p.9521-9528
Hauptverfasser:	Aub, D L, Gosse, M E, Cote, T E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell Membrane - metabolism Cell physiology Enzyme Activation Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism Guanosine Diphosphate - pharmacology Guanosine Triphosphate - pharmacology Hormonal regulation Kinetics Molecular and cellular biology Rats Receptors, Neurotransmitter - metabolism Receptors, Thyrotropin-Releasing Hormone Thyrotropin-Releasing Hormone - metabolism Type C Phospholipases - metabolism
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