Essential thrombocythemia with acquired von Willebrand's disease
Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one p...
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| Veröffentlicht in: | American journal of clinical pathology 1987-07, Vol.88 (1), p.102-106 |
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| container_end_page | 106 |
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| container_issue | 1 |
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| container_title | American journal of clinical pathology |
| container_volume | 88 |
| creator | RAMAN, B. K. S SAWDYK, M SAEED, S. M |
| description | Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of vWD compatible with type IIA defect in the second patient. The latter patient had minor episodes of epistaxis clinically, while the patient with type I disease experienced excessive blood loss during menstrual periods. Both patients gave negative history for abnormal bleeding in the past or in their families. Both have had uneventful surgical procedures in the past, at which time bleeding times and basic coagulation test results were normal. |
| doi_str_mv | 10.1093/ajcp/88.1.102 |
| format | Article |
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Both have had uneventful surgical procedures in the past, at which time bleeding times and basic coagulation test results were normal.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/88.1.102</identifier><identifier>PMID: 3496780</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Humans ; Medical sciences ; Middle Aged ; Platelet diseases and coagulopathies ; Thrombocythemia, Essential - complications ; von Willebrand Diseases - complications ; von Willebrand Diseases - diagnosis</subject><ispartof>American journal of clinical pathology, 1987-07, Vol.88 (1), p.102-106</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c232t-7892ef068c341443dd8c687e9a63c40a675c7fb8ad3d1a4416f1760cbdb4b8c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8264553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3496780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAMAN, B. K. S</creatorcontrib><creatorcontrib>SAWDYK, M</creatorcontrib><creatorcontrib>SAEED, S. M</creatorcontrib><title>Essential thrombocythemia with acquired von Willebrand's disease</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of vWD compatible with type IIA defect in the second patient. The latter patient had minor episodes of epistaxis clinically, while the patient with type I disease experienced excessive blood loss during menstrual periods. Both patients gave negative history for abnormal bleeding in the past or in their families. Both have had uneventful surgical procedures in the past, at which time bleeding times and basic coagulation test results were normal.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet diseases and coagulopathies</subject><subject>Thrombocythemia, Essential - complications</subject><subject>von Willebrand Diseases - complications</subject><subject>von Willebrand Diseases - diagnosis</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVaXLoVZiK6mzWuSzE4p9QEFN4rLkEkyNGUebe6M0n_vFIeuLofznQP3IHRL8JzgnC3M1u4WSs3JIOkZmpKcs1RKSs_RFGNM05xIdomuALYYE6own6AJ47mQCk_R0wrAN10wVdJtYlsXrT10G18Hk_yGbpMYu-9D9C75aZvkO1SVL6Jp3CMkLoA34K_RRWkq8DfjnaGvl9Xn8i1df7y-L5_XqaWMdqlUOfUlFsoyTjhnzikrlPS5EcxybITMrCwLZRxzxHBOREmkwLZwBS-GEJuhh__eXWz3vYdO1wGsryrT-LYHLaUgJMvyAUz_QRtbgOhLvYuhNvGgCdbHxfRxMa2UJoOkA383FvdF7d2JHica_PvRN2BNVQ7v2wAnTFHBs4yxPy4_dAQ</recordid><startdate>198707</startdate><enddate>198707</enddate><creator>RAMAN, B. K. S</creator><creator>SAWDYK, M</creator><creator>SAEED, S. M</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198707</creationdate><title>Essential thrombocythemia with acquired von Willebrand's disease</title><author>RAMAN, B. K. S ; SAWDYK, M ; SAEED, S. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c232t-7892ef068c341443dd8c687e9a63c40a675c7fb8ad3d1a4416f1760cbdb4b8c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet diseases and coagulopathies</topic><topic>Thrombocythemia, Essential - complications</topic><topic>von Willebrand Diseases - complications</topic><topic>von Willebrand Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAMAN, B. K. S</creatorcontrib><creatorcontrib>SAWDYK, M</creatorcontrib><creatorcontrib>SAEED, S. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Essential thrombocythemia with acquired von Willebrand's disease</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1987-07</date><risdate>1987</risdate><volume>88</volume><issue>1</issue><spage>102</spage><epage>106</epage><pages>102-106</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of vWD compatible with type IIA defect in the second patient. The latter patient had minor episodes of epistaxis clinically, while the patient with type I disease experienced excessive blood loss during menstrual periods. Both patients gave negative history for abnormal bleeding in the past or in their families. Both have had uneventful surgical procedures in the past, at which time bleeding times and basic coagulation test results were normal.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>3496780</pmid><doi>10.1093/ajcp/88.1.102</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1987-07, Vol.88 (1), p.102-106 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77611559 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Medical sciences Middle Aged Platelet diseases and coagulopathies Thrombocythemia, Essential - complications von Willebrand Diseases - complications von Willebrand Diseases - diagnosis |
| title | Essential thrombocythemia with acquired von Willebrand's disease |
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