Leukotrienes LTB4 and LTC4 in thermally injured patients' plasma and burn blister fluid
Radioimmunoassays for 5(S), 12(R)-dihydroxyeicosa-6, 14-cis, 8,10-trans-tetraenoic acid (leukotriene B4, LTB4) and 5(S)-hydroxy-6(R)-L-gamma-glutamyl-L-cysteinyl-glycinyleicosa-7,9- trans, 11,14-cis-tetraenoic acid (leukotriene C4, LTC4) have been used to quantify the concentrations of these arachid...
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| Veröffentlicht in: | Journal of burn care & rehabilitation 1987-05, Vol.8 (3), p.189-191 |
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| container_title | Journal of burn care & rehabilitation |
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| creator | Dobke, M K Hayes, E C Baxter, C R |
| description | Radioimmunoassays for 5(S), 12(R)-dihydroxyeicosa-6, 14-cis, 8,10-trans-tetraenoic acid (leukotriene B4, LTB4) and 5(S)-hydroxy-6(R)-L-gamma-glutamyl-L-cysteinyl-glycinyleicosa-7,9- trans, 11,14-cis-tetraenoic acid (leukotriene C4, LTC4) have been used to quantify the concentrations of these arachidonic acid metabolites in plasma (12 patients) and blister fluid (6 patients) of burned patients. The results of this study demonstrate that, in general, burn plasma LTB4, and LTC4 were not elevated; however, in individual cases, transient high levels of leukotrienes were observed. Correlation between leukotriene "peaks" and the clinical course could not be established. High levels of LTB4 and LTC4 in burn blister fluid suggest their participation in local inflammatory reactions. |
| doi_str_mv | 10.1097/00004630-198705000-00002 |
| format | Article |
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The results of this study demonstrate that, in general, burn plasma LTB4, and LTC4 were not elevated; however, in individual cases, transient high levels of leukotrienes were observed. Correlation between leukotriene "peaks" and the clinical course could not be established. High levels of LTB4 and LTC4 in burn blister fluid suggest their participation in local inflammatory reactions.</description><identifier>ISSN: 0273-8481</identifier><identifier>DOI: 10.1097/00004630-198705000-00002</identifier><identifier>PMID: 3038921</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Burns - metabolism ; Exudates and Transudates - analysis ; Female ; Humans ; Leukotriene B4 - analysis ; Leukotriene B4 - blood ; Male ; Middle Aged ; Prognosis ; Radioimmunoassay ; SRS-A - analysis</subject><ispartof>Journal of burn care & rehabilitation, 1987-05, Vol.8 (3), p.189-191</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3038921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobke, M K</creatorcontrib><creatorcontrib>Hayes, E C</creatorcontrib><creatorcontrib>Baxter, C R</creatorcontrib><title>Leukotrienes LTB4 and LTC4 in thermally injured patients' plasma and burn blister fluid</title><title>Journal of burn care & rehabilitation</title><addtitle>J Burn Care Rehabil</addtitle><description>Radioimmunoassays for 5(S), 12(R)-dihydroxyeicosa-6, 14-cis, 8,10-trans-tetraenoic acid (leukotriene B4, LTB4) and 5(S)-hydroxy-6(R)-L-gamma-glutamyl-L-cysteinyl-glycinyleicosa-7,9- trans, 11,14-cis-tetraenoic acid (leukotriene C4, LTC4) have been used to quantify the concentrations of these arachidonic acid metabolites in plasma (12 patients) and blister fluid (6 patients) of burned patients. The results of this study demonstrate that, in general, burn plasma LTB4, and LTC4 were not elevated; however, in individual cases, transient high levels of leukotrienes were observed. Correlation between leukotriene "peaks" and the clinical course could not be established. High levels of LTB4 and LTC4 in burn blister fluid suggest their participation in local inflammatory reactions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Burns - metabolism</subject><subject>Exudates and Transudates - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Leukotriene B4 - analysis</subject><subject>Leukotriene B4 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Radioimmunoassay</subject><subject>SRS-A - analysis</subject><issn>0273-8481</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOxDAMRbMADcPAJyBlBatCnLRNu4QRL6kSm0EsK6dJRYf0QR6L-XsCjDf2tY6vbBNCgd0Cq-UdS5GXgmVQV5IVSWW_LX5C1oxLkVV5BWfk3Ps9Y1DLsliRlWCiqjmsyUdj4tcc3GAm42mze8gpTjoV25wOEw2fxo1o7SGJfXRG0wVDYoO_oYtFP-IfrqKbqLKDD8bR3sZBX5DTHq03l8e8Ie9Pj7vtS9a8Pb9u75tsAQ4h42Unoc5lYTrsZQ8oVK8V06BFl9aGsgMDTCDWJmc6XatRVYCdAMW55lpsyPW_7-Lm72h8aMfBd8ZanMwcfStlmaZYkcCrIxjVaHS7uGFEd2iPnxA_Pjhfiw</recordid><startdate>198705</startdate><enddate>198705</enddate><creator>Dobke, M K</creator><creator>Hayes, E C</creator><creator>Baxter, C R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198705</creationdate><title>Leukotrienes LTB4 and LTC4 in thermally injured patients' plasma and burn blister fluid</title><author>Dobke, M K ; Hayes, E C ; Baxter, C R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-26c719475ecaf7f1a3bfdb0d1d3c48116c1e103aa9e40d097dab81ac31b22d2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Burns - metabolism</topic><topic>Exudates and Transudates - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Leukotriene B4 - analysis</topic><topic>Leukotriene B4 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Radioimmunoassay</topic><topic>SRS-A - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobke, M K</creatorcontrib><creatorcontrib>Hayes, E C</creatorcontrib><creatorcontrib>Baxter, C R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of burn care & rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobke, M K</au><au>Hayes, E C</au><au>Baxter, C R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukotrienes LTB4 and LTC4 in thermally injured patients' plasma and burn blister fluid</atitle><jtitle>Journal of burn care & rehabilitation</jtitle><addtitle>J Burn Care Rehabil</addtitle><date>1987-05</date><risdate>1987</risdate><volume>8</volume><issue>3</issue><spage>189</spage><epage>191</epage><pages>189-191</pages><issn>0273-8481</issn><abstract>Radioimmunoassays for 5(S), 12(R)-dihydroxyeicosa-6, 14-cis, 8,10-trans-tetraenoic acid (leukotriene B4, LTB4) and 5(S)-hydroxy-6(R)-L-gamma-glutamyl-L-cysteinyl-glycinyleicosa-7,9- trans, 11,14-cis-tetraenoic acid (leukotriene C4, LTC4) have been used to quantify the concentrations of these arachidonic acid metabolites in plasma (12 patients) and blister fluid (6 patients) of burned patients. The results of this study demonstrate that, in general, burn plasma LTB4, and LTC4 were not elevated; however, in individual cases, transient high levels of leukotrienes were observed. Correlation between leukotriene "peaks" and the clinical course could not be established. High levels of LTB4 and LTC4 in burn blister fluid suggest their participation in local inflammatory reactions.</abstract><cop>United States</cop><pmid>3038921</pmid><doi>10.1097/00004630-198705000-00002</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of burn care & rehabilitation, 1987-05, Vol.8 (3), p.189-191 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete - AutoHoldings; Alma/SFX Local Collection |
| subjects | Adolescent Adult Burns - metabolism Exudates and Transudates - analysis Female Humans Leukotriene B4 - analysis Leukotriene B4 - blood Male Middle Aged Prognosis Radioimmunoassay SRS-A - analysis |
| title | Leukotrienes LTB4 and LTC4 in thermally injured patients' plasma and burn blister fluid |
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