Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

Tumour necrosis factor alpha (TNF alpha) has been found to cause a delipidation of fat cells and a decrease of the adipose tissue mass. In the present study, we tried to elucidate some of the mechanisms responsible for this phenomenon by investigating the action of TNF alpha on specific pathways whi...

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Veröffentlicht in:	Diabetologia 1995-07, Vol.38 (7), p.764-771
Hauptverfasser:	HAUNER, H, PETRUSCHKE, T, RUSS, M, RÖHRIG, K, ECKEL, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism Adolescent Adult Biological and medical sciences Biological Transport - drug effects Cell Differentiation Cell Fractionation Cell Membrane - metabolism Cell Membrane - ultrastructure Cells, Cultured Deoxyglucose - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Glucose - metabolism Glucose Transporter Type 1 Glucose Transporter Type 4 Humans Lipid Metabolism Lipoprotein Lipase - biosynthesis Monosaccharide Transport Proteins - drug effects Monosaccharide Transport Proteins - metabolism Muscle Proteins Recombinant Proteins - pharmacology RNA, Messenger - analysis RNA, Messenger - biosynthesis Tumor Necrosis Factor-alpha - pharmacology Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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