Behavior of Nuclear Matrix Proteins during Camptothecin-Induced Apoptosis in HL-60 Human Leukemia Cells

In this study we focused our attention on the behavior of four nuclear matrix proteins during the various stages of apoptosis in the HL-60 cell line exposed to the DNA topoisomerase I inhibitor, camptothecin. We have examined the following antigens by immunocytochemical techniques: (i) the 180-kDa n...

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Veröffentlicht in:	Experimental cell research 1995-11, Vol.221 (1), p.27-40
Hauptverfasser:	Zweyer, Marina, Bareggi, Renato, Grill, Vittorio, Soranzo, Maria Rosa, Marugg, Richard A., Riederer, Beat M., Narducci, Paola, Martelli, Alberto M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis - physiology Autoantigens - metabolism Camptothecin - pharmacology DNA Topoisomerases, Type II - immunology DNA Topoisomerases, Type II - metabolism Fluorescent Antibody Technique, Indirect HL-60 Cells - cytology HL-60 Cells - ultrastructure Humans Immunohistochemistry Isoenzymes - immunology Isoenzymes - metabolism Micronuclei, Chromosome-Defective - enzymology Microscopy, Electron Nuclear Matrix - enzymology Nuclear Proteins - immunology Nuclear Proteins - metabolism
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