CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia
To further investigate the hypothesis that hyperactivity of the hypothalamic-pituitary-adrenal axis in patients with depression may be mediated by hypersecretion of corticotropin-releasing factor (CRF), the authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 d...
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| Veröffentlicht in: | The American journal of psychiatry 1987-07, Vol.144 (7), p.873-877 |
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| container_title | The American journal of psychiatry |
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| creator | BANKI, C. M BISSETTE, G ARATO, M O'CONNOR, L NEMEROFF, C. B |
| description | To further investigate the hypothesis that hyperactivity of the
hypothalamic-pituitary-adrenal axis in patients with depression may be
mediated by hypersecretion of corticotropin-releasing factor (CRF), the
authors measured CRF-like immunoreactivity in CSF samples from 138
neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic
and four manic) subjects. The CSF CRF concentration was markedly higher
(almost twofold) in depressed patients than in control subjects and
nondepressed psychiatric patients. The concentration of CSF CRF was
slightly but significantly higher in schizophrenic patients than in control
subjects. These findings provide further support for the hypothesis that
CRF hypersecretion occurs in major depression. |
| doi_str_mv | 10.1176/ajp.144.7.873 |
| format | Article |
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hypothalamic-pituitary-adrenal axis in patients with depression may be
mediated by hypersecretion of corticotropin-releasing factor (CRF), the
authors measured CRF-like immunoreactivity in CSF samples from 138
neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic
and four manic) subjects. The CSF CRF concentration was markedly higher
(almost twofold) in depressed patients than in control subjects and
nondepressed psychiatric patients. The concentration of CSF CRF was
slightly but significantly higher in schizophrenic patients than in control
subjects. These findings provide further support for the hypothesis that
CRF hypersecretion occurs in major depression.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.144.7.873</identifier><identifier>PMID: 3496802</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Biological and medical sciences ; Corticotropin-Releasing Hormone - cerebrospinal fluid ; Corticotropin-Releasing Hormone - immunology ; Depressive Disorder - cerebrospinal fluid ; Depressive Disorder - diagnosis ; Dexamethasone ; Female ; Humans ; Hydrocortisone - blood ; Male ; Medical research ; Medical sciences ; Mental depression ; Miscellaneous ; Nervous System Diseases - cerebrospinal fluid ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Schizophrenia ; Schizophrenia - cerebrospinal fluid ; Schizophrenia - diagnosis ; Techniques and methods</subject><ispartof>The American journal of psychiatry, 1987-07, Vol.144 (7), p.873-877</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Jul 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a473t-b2ff168f05fb3ba7dad05bf989795e83ca21ad6e7f315049db97f6005ecd1cf33</citedby><cites>FETCH-LOGICAL-a473t-b2ff168f05fb3ba7dad05bf989795e83ca21ad6e7f315049db97f6005ecd1cf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.144.7.873$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.144.7.873$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2859,21629,27869,27924,27925,77791,77792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7536610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3496802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANKI, C. M</creatorcontrib><creatorcontrib>BISSETTE, G</creatorcontrib><creatorcontrib>ARATO, M</creatorcontrib><creatorcontrib>O'CONNOR, L</creatorcontrib><creatorcontrib>NEMEROFF, C. B</creatorcontrib><title>CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>To further investigate the hypothesis that hyperactivity of the
hypothalamic-pituitary-adrenal axis in patients with depression may be
mediated by hypersecretion of corticotropin-releasing factor (CRF), the
authors measured CRF-like immunoreactivity in CSF samples from 138
neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic
and four manic) subjects. The CSF CRF concentration was markedly higher
(almost twofold) in depressed patients than in control subjects and
nondepressed psychiatric patients. The concentration of CSF CRF was
slightly but significantly higher in schizophrenic patients than in control
subjects. These findings provide further support for the hypothesis that
CRF hypersecretion occurs in major depression.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Corticotropin-Releasing Hormone - cerebrospinal fluid</subject><subject>Corticotropin-Releasing Hormone - immunology</subject><subject>Depressive Disorder - cerebrospinal fluid</subject><subject>Depressive Disorder - diagnosis</subject><subject>Dexamethasone</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Miscellaneous</subject><subject>Nervous System Diseases - cerebrospinal fluid</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Schizophrenia</subject><subject>Schizophrenia - cerebrospinal fluid</subject><subject>Schizophrenia - diagnosis</subject><subject>Techniques and methods</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp10c1rFDEYBvAglrq2Hj0Kg4oHYbZvksnHHGVpVSj00BZ6C5lMYrPOJGMyU2j_-qbsUkTsKSTvjycvPAi9x7DGWPATvZ3WuGnWYi0FfYVWmFFWC0Lka7QCAFK3jN68QW9z3pYrUEEO0SFtWi6BrNDN5vKsMjHN3sQ5xcmHOtnB6uzDr8ppM8dUD_63rfw4LiEmW578nZ_vKx-q3k7J5uxjqHToq2xu_UOcbpMNXh-jA6eHbN_tzyN0fXZ6tflRn198_7n5dl7rRtC57ohzmEsHzHW006LXPbDOtbIVLbOSGk2w7rkVjmIGTdt3rXAcgFnTY-MoPUJfdrlTin8Wm2c1-mzsMOhg45KVEBy4lKTAj__AbVxSKLspQqDhmLKntE8vIUwxcJDAmqLqnTIp5pysU1Pyo073CoN6KkWVUlQpRQlVSin-wz516UbbP-t9C2X-eT_X2ejBJR2Mz89MMMo5hsK-7pieJv_XYv_98xFuPqLY</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>BANKI, C. M</creator><creator>BISSETTE, G</creator><creator>ARATO, M</creator><creator>O'CONNOR, L</creator><creator>NEMEROFF, C. B</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19870701</creationdate><title>CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia</title><author>BANKI, C. M ; BISSETTE, G ; ARATO, M ; O'CONNOR, L ; NEMEROFF, C. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a473t-b2ff168f05fb3ba7dad05bf989795e83ca21ad6e7f315049db97f6005ecd1cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Corticotropin-Releasing Hormone - cerebrospinal fluid</topic><topic>Corticotropin-Releasing Hormone - immunology</topic><topic>Depressive Disorder - cerebrospinal fluid</topic><topic>Depressive Disorder - diagnosis</topic><topic>Dexamethasone</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Miscellaneous</topic><topic>Nervous System Diseases - cerebrospinal fluid</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Schizophrenia</topic><topic>Schizophrenia - cerebrospinal fluid</topic><topic>Schizophrenia - diagnosis</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANKI, C. M</creatorcontrib><creatorcontrib>BISSETTE, G</creatorcontrib><creatorcontrib>ARATO, M</creatorcontrib><creatorcontrib>O'CONNOR, L</creatorcontrib><creatorcontrib>NEMEROFF, C. 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M</au><au>BISSETTE, G</au><au>ARATO, M</au><au>O'CONNOR, L</au><au>NEMEROFF, C. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>144</volume><issue>7</issue><spage>873</spage><epage>877</epage><pages>873-877</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>To further investigate the hypothesis that hyperactivity of the
hypothalamic-pituitary-adrenal axis in patients with depression may be
mediated by hypersecretion of corticotropin-releasing factor (CRF), the
authors measured CRF-like immunoreactivity in CSF samples from 138
neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic
and four manic) subjects. The CSF CRF concentration was markedly higher
(almost twofold) in depressed patients than in control subjects and
nondepressed psychiatric patients. The concentration of CSF CRF was
slightly but significantly higher in schizophrenic patients than in control
subjects. These findings provide further support for the hypothesis that
CRF hypersecretion occurs in major depression.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>3496802</pmid><doi>10.1176/ajp.144.7.873</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1987-07, Vol.144 (7), p.873-877 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77606882 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Biological and medical sciences Corticotropin-Releasing Hormone - cerebrospinal fluid Corticotropin-Releasing Hormone - immunology Depressive Disorder - cerebrospinal fluid Depressive Disorder - diagnosis Dexamethasone Female Humans Hydrocortisone - blood Male Medical research Medical sciences Mental depression Miscellaneous Nervous System Diseases - cerebrospinal fluid Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Schizophrenia Schizophrenia - cerebrospinal fluid Schizophrenia - diagnosis Techniques and methods |
| title | CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia |
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