Analysis of the mechanism of action of bradykinin on human basilar artery in vitro
Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals to BK over an 8 h period were reproducible. The rank order of potency of three kinins on the human basilar artery was found to be BK greater...
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Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1987-04, Vol.335 (4), p.433-437 |
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description | Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals to BK over an 8 h period were reproducible. The rank order of potency of three kinins on the human basilar artery was found to be BK greater than methionyl-lysyl-BK greater than des-Arg9-BK. The B2-receptor antagonist Thi5,8, D-Phe7-BK but not the B1-receptor antagonist des-Arg9-Leu8-BK selectively blocked BK-induced relaxations of the human basilar artery. The relaxant effects of bradykinin and acetylcholine but not papaverine were attenuated after removal of the endothelium or treating the tissues with BW755C. Indomethacin was without effect. Concentration-effect curves to angiotensin I were markedly attenuated by captopril at a concentration which had no effect on BK, angiotensin II or 5-hydroxytryptamine responses. It is concluded that BK induced relaxations of the human basilar artery are mediated via activation of a B2 receptor and the response is dependent upon the release of a factor present in the endothelium. Angiotensin converting enzyme is present in the human basilar artery and is important for the conversion of angiotensin I to angiotensin II but apparently not for the degradation of BK. It is likely that other kininases are present and active in the tissue. |
doi_str_mv | 10.1007/bf00165559 |
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T ; AMURE, Y. O ; LYE, R. H</creator><creatorcontrib>WHALLEY, E. T ; AMURE, Y. O ; LYE, R. H</creatorcontrib><description>Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals to BK over an 8 h period were reproducible. The rank order of potency of three kinins on the human basilar artery was found to be BK greater than methionyl-lysyl-BK greater than des-Arg9-BK. The B2-receptor antagonist Thi5,8, D-Phe7-BK but not the B1-receptor antagonist des-Arg9-Leu8-BK selectively blocked BK-induced relaxations of the human basilar artery. The relaxant effects of bradykinin and acetylcholine but not papaverine were attenuated after removal of the endothelium or treating the tissues with BW755C. Indomethacin was without effect. Concentration-effect curves to angiotensin I were markedly attenuated by captopril at a concentration which had no effect on BK, angiotensin II or 5-hydroxytryptamine responses. It is concluded that BK induced relaxations of the human basilar artery are mediated via activation of a B2 receptor and the response is dependent upon the release of a factor present in the endothelium. Angiotensin converting enzyme is present in the human basilar artery and is important for the conversion of angiotensin I to angiotensin II but apparently not for the degradation of BK. It is likely that other kininases are present and active in the tissue.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/bf00165559</identifier><identifier>PMID: 3037391</identifier><identifier>CODEN: NSAPCC</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Acetylcholine - metabolism ; basilar artery ; Basilar Artery - drug effects ; Biological and medical sciences ; Blood vessels and receptors ; bradykinin ; Bradykinin - pharmacology ; Endothelium - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; In Vitro Techniques ; Muscle Relaxation - drug effects ; Muscle, Smooth, Vascular - drug effects ; Papaverine - pharmacology ; Peptidyl-Dipeptidase A - metabolism ; Vertebrates: cardiovascular system</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 1987-04, Vol.335 (4), p.433-437</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-ef0cf3527e9c0bed71f101401f929a799e6db10a2558a500629f39617d71a56b3</citedby><cites>FETCH-LOGICAL-c323t-ef0cf3527e9c0bed71f101401f929a799e6db10a2558a500629f39617d71a56b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7531770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3037391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WHALLEY, E. T</creatorcontrib><creatorcontrib>AMURE, Y. O</creatorcontrib><creatorcontrib>LYE, R. H</creatorcontrib><title>Analysis of the mechanism of action of bradykinin on human basilar artery in vitro</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals to BK over an 8 h period were reproducible. The rank order of potency of three kinins on the human basilar artery was found to be BK greater than methionyl-lysyl-BK greater than des-Arg9-BK. The B2-receptor antagonist Thi5,8, D-Phe7-BK but not the B1-receptor antagonist des-Arg9-Leu8-BK selectively blocked BK-induced relaxations of the human basilar artery. The relaxant effects of bradykinin and acetylcholine but not papaverine were attenuated after removal of the endothelium or treating the tissues with BW755C. Indomethacin was without effect. Concentration-effect curves to angiotensin I were markedly attenuated by captopril at a concentration which had no effect on BK, angiotensin II or 5-hydroxytryptamine responses. It is concluded that BK induced relaxations of the human basilar artery are mediated via activation of a B2 receptor and the response is dependent upon the release of a factor present in the endothelium. Angiotensin converting enzyme is present in the human basilar artery and is important for the conversion of angiotensin I to angiotensin II but apparently not for the degradation of BK. It is likely that other kininases are present and active in the tissue.</description><subject>Acetylcholine - metabolism</subject><subject>basilar artery</subject><subject>Basilar Artery - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood vessels and receptors</subject><subject>bradykinin</subject><subject>Bradykinin - pharmacology</subject><subject>Endothelium - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Papaverine - pharmacology</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Vertebrates: cardiovascular system</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLAzEQxoMotT4u3oU9iAdhdSZpNs2xilVBEETPy2ya0Og-arIV9r83pdWrzGEe34-P4WPsDOEaAdRN5QCwkFLqPTbGieA5auT7bAzApzlyPT1kRzF-AECBUo7YSIBQQuOYvc5aqofoY9a5rF_arLFmSa2PzeZApvddu5mqQIvh07c-bW22XDfUZhVFX1PIKPQ2DFmSvn0fuhN24KiO9nTXj9n7_P7t7jF_fnl4ups950Zw0efWgXFCcmW1gcouFDoEnAA6zTUprW2xqBCISzklmT7n2gldoEokyaISx-xy67sK3dfaxr5sfDS2rqm13TqWShWQqvgXxInCIn2SwKstaEIXY7CuXAXfUBhKhHKTdHk7_006wec713XV2MUfuos26Rc7naKh2gVqjY9_mJIClQLxA8UUg8U</recordid><startdate>198704</startdate><enddate>198704</enddate><creator>WHALLEY, E. T</creator><creator>AMURE, Y. O</creator><creator>LYE, R. H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198704</creationdate><title>Analysis of the mechanism of action of bradykinin on human basilar artery in vitro</title><author>WHALLEY, E. T ; AMURE, Y. O ; LYE, R. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-ef0cf3527e9c0bed71f101401f929a799e6db10a2558a500629f39617d71a56b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acetylcholine - metabolism</topic><topic>basilar artery</topic><topic>Basilar Artery - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood vessels and receptors</topic><topic>bradykinin</topic><topic>Bradykinin - pharmacology</topic><topic>Endothelium - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Papaverine - pharmacology</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WHALLEY, E. T</creatorcontrib><creatorcontrib>AMURE, Y. O</creatorcontrib><creatorcontrib>LYE, R. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WHALLEY, E. T</au><au>AMURE, Y. O</au><au>LYE, R. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the mechanism of action of bradykinin on human basilar artery in vitro</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>1987-04</date><risdate>1987</risdate><volume>335</volume><issue>4</issue><spage>433</spage><epage>437</epage><pages>433-437</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><coden>NSAPCC</coden><abstract>Bradykinin (BK) initially produced concentration-related relaxations of human basilar artery in vitro. Concentration-effect curves constructed at 2 h intervals to BK over an 8 h period were reproducible. The rank order of potency of three kinins on the human basilar artery was found to be BK greater than methionyl-lysyl-BK greater than des-Arg9-BK. The B2-receptor antagonist Thi5,8, D-Phe7-BK but not the B1-receptor antagonist des-Arg9-Leu8-BK selectively blocked BK-induced relaxations of the human basilar artery. The relaxant effects of bradykinin and acetylcholine but not papaverine were attenuated after removal of the endothelium or treating the tissues with BW755C. Indomethacin was without effect. Concentration-effect curves to angiotensin I were markedly attenuated by captopril at a concentration which had no effect on BK, angiotensin II or 5-hydroxytryptamine responses. It is concluded that BK induced relaxations of the human basilar artery are mediated via activation of a B2 receptor and the response is dependent upon the release of a factor present in the endothelium. Angiotensin converting enzyme is present in the human basilar artery and is important for the conversion of angiotensin I to angiotensin II but apparently not for the degradation of BK. It is likely that other kininases are present and active in the tissue.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>3037391</pmid><doi>10.1007/bf00165559</doi><tpages>5</tpages></addata></record> |
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subjects | Acetylcholine - metabolism basilar artery Basilar Artery - drug effects Biological and medical sciences Blood vessels and receptors bradykinin Bradykinin - pharmacology Endothelium - physiology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Papaverine - pharmacology Peptidyl-Dipeptidase A - metabolism Vertebrates: cardiovascular system |
title | Analysis of the mechanism of action of bradykinin on human basilar artery in vitro |
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