An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization
A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic leukemia (APL). The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a d...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1995-09, Vol.83 (2), p.136-139 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Hiorns, Lynne R. John Swansbury, G. Catovsky, Daniel |
| description | A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic leukemia (APL). The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a der(15) chromosome consistent with the der(15) chromosome of the t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans retinoic acid (ATRA) and had a clinical course typical of the disease, which is currently in remission after an autologous bone marrow transplant. The other structural rearrangements appeared to have little effect on the biology of the neoplasia. |
| doi_str_mv | 10.1016/0165-4608(95)00048-T |
| format | Article |
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The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a der(15) chromosome consistent with the der(15) chromosome of the t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans retinoic acid (ATRA) and had a clinical course typical of the disease, which is currently in remission after an autologous bone marrow transplant. The other structural rearrangements appeared to have little effect on the biology of the neoplasia.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(95)00048-T</identifier><identifier>PMID: 7553583</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chromosome Mapping ; Chromosomes, Human, Pair 15 ; Chromosomes, Human, Pair 17 ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemia, Promyelocytic, Acute - genetics ; Leukemia, Promyelocytic, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a der(15) chromosome consistent with the der(15) chromosome of the t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans retinoic acid (ATRA) and had a clinical course typical of the disease, which is currently in remission after an autologous bone marrow transplant. The other structural rearrangements appeared to have little effect on the biology of the neoplasia.</description><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotyping</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Leukemia, Promyelocytic, Acute - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Translocation, Genetic</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3TAQRkVpSG_S_oMWtCglWTiVbMmWCRRC6CMQyOZ2LWRpnEzrR6JHivvrI_de7rILocWcb_jmEPKeswvOeP05P1mImqmzVp4zxoQqtq_IhqumKoSQ9WuyOSBvyEkIvzLUlG19TI4bKSupqg15upoo4P1DLP6YhT4bj2aKNJ5xecmbc4oTNTZFoI9-HhcYZrtEtHSA9BtGNBSGZNGZCI6mgNM97Yc0ewgWJgtrOmBM9GHpPDr8ayLO01ty1JshwLv9f0p-fvu6vf5R3N59v7m-ui1sxXgslOrrUrHOdQ4kAPQKZMtYpZre8JJ1SnSVUFwJm09xFVjHulqozpSOcdGI6pR82u3N1Z8ShKhHzL2GwUwwp6CbpmZStjKDYgdaP4fgodePHkfjF82ZXk3rVaNeNepW6n-m9TbHPuz3p24Edwjt1eb5x_3cBGuG3pvJYjhgVa1EKduMfdlhkF08I3gdLK72HHqwUbsZ_9_jBTgWmuY</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>Hiorns, Lynne R.</creator><creator>John Swansbury, G.</creator><creator>Catovsky, Daniel</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199509</creationdate><title>An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization</title><author>Hiorns, Lynne R. ; John Swansbury, G. ; Catovsky, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-88f6280bdbde5eeef8e5900387fa120b84b348184c553d3ecd0b648ba2d014743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Karyotyping</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Leukemia, Promyelocytic, Acute - therapy</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Translocation, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Hiorns, Lynne R.</creatorcontrib><creatorcontrib>John Swansbury, G.</creatorcontrib><creatorcontrib>Catovsky, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiorns, Lynne R.</au><au>John Swansbury, G.</au><au>Catovsky, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1995-09</date><risdate>1995</risdate><volume>83</volume><issue>2</issue><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>A complex eight-way translocation was identified, with the aid of fluorescence in situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic leukemia (APL). The balanced translocation was defined as 46,XY,t(1;6;7;6;17;15;12;3)(p22;q27;p15;q13;q21;q22;q13;p13), which includes a der(15) chromosome consistent with the der(15) chromosome of the t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans retinoic acid (ATRA) and had a clinical course typical of the disease, which is currently in remission after an autologous bone marrow transplant. The other structural rearrangements appeared to have little effect on the biology of the neoplasia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7553583</pmid><doi>10.1016/0165-4608(95)00048-T</doi><tpages>4</tpages></addata></record> |
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| ispartof | Cancer genetics and cytogenetics, 1995-09, Vol.83 (2), p.136-139 |
| issn | 0165-4608 1873-4456 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Translocation, Genetic |
| title | An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using fluorescence in situ hybridization |
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