Axonal transport of the synaptic vesicle monoamine carrier identified by [ 3H]dihydrotetrabenazine binding in rat sciatic nerve
The monoamine carrier of noradrenergic synaptic vesicles was assayed in the rat sciatic nerve by in vitro binding of [ 3H]dihydrotetrabenazine. The number of binding sites increased with time on both sides of a ligature, indicating fast anterograde and retrograde axoplasmic transports of comparable...
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| Veröffentlicht in: | Neuroscience letters 1987-06, Vol.77 (2), p.231-236 |
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| container_title | Neuroscience letters |
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| creator | Scherman, D. Janssen, P.F.M. Laduron, P.M. |
| description | The monoamine carrier of noradrenergic synaptic vesicles was assayed in the rat sciatic nerve by in vitro binding of [
3H]dihydrotetrabenazine. The number of binding sites increased with time on both sides of a ligature, indicating fast anterograde and retrograde axoplasmic transports of comparable amplitude. Anterogradely and retrogradely transported binding sites had similar pharmacological properties, which were characteristic of binding to the monoamine carrier embedded within a lipid bilayer. Contrary to the secreted synaptic vesicle matrix constituents, the intrinsic monoamine carrier assayed by [
3H]dihydrotetrabenazine binding is a marker adapted to retrograde transport studies. |
| doi_str_mv | 10.1016/0304-3940(87)90592-1 |
| format | Article |
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3H]dihydrotetrabenazine. The number of binding sites increased with time on both sides of a ligature, indicating fast anterograde and retrograde axoplasmic transports of comparable amplitude. Anterogradely and retrogradely transported binding sites had similar pharmacological properties, which were characteristic of binding to the monoamine carrier embedded within a lipid bilayer. Contrary to the secreted synaptic vesicle matrix constituents, the intrinsic monoamine carrier assayed by [
3H]dihydrotetrabenazine binding is a marker adapted to retrograde transport studies.</description><subject>Animals</subject><subject>Axonal Transport</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active</subject><subject>Dihydrotetrabenazine binding</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Lipid Bilayers - metabolism</subject><subject>Monoamine carrier</subject><subject>Rat sciatic nerve</subject><subject>Rats</subject><subject>Sciatic Nerve - metabolism</subject><subject>Synaptic Vesicles - metabolism</subject><subject>Tetrabenazine - analogs & derivatives</subject><subject>Tetrabenazine - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEURYMoYzv6BwpZiOiiNKmkKqmNMAzqCANudCUSUi-vnEhV0ibpxnbjr5uym166eot77uVxCHnK2WvOeP-GCSYbMUj2UqtXA-uGtuH3yIZr1TZqUO19sjkjD8mjnH8wxjreyQty0UoxDJ3ekD9Xv2KwMy3JhryNqdA40XKHNB-C3RYPdI_Zw4x0iSHaxQekYFPymKh3GIqfPDo6HuhXKm6-OX93cCkWrHsjBvt75UcfnA_fqQ802UIzeLsOB0x7fEweTHbO-OR0L8mX9-8-X980t58-fLy-um1A6L402OKkJweDE6qTCsQoWiu06vsRGLbSAmgJrBNODW5CGFrBO6ZHLh1ymIS4JC-Ou9sUf-4wF7P4DDjPNmDcZaNUz2QVVUF5BCHFnBNOZpv8YtPBcGZW72aValapRivzz7vhtfbstL8bF3Tn0kl0zZ-fcpvBzlPVDT6fMS1Y28muYm-PGFYX-yrZVFsYAJ1PCMW46P__x1938qFQ</recordid><startdate>19870615</startdate><enddate>19870615</enddate><creator>Scherman, D.</creator><creator>Janssen, P.F.M.</creator><creator>Laduron, P.M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870615</creationdate><title>Axonal transport of the synaptic vesicle monoamine carrier identified by [ 3H]dihydrotetrabenazine binding in rat sciatic nerve</title><author>Scherman, D. ; Janssen, P.F.M. ; Laduron, P.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e2ef8fdc9d37547c3b32a38766bc0e24acc84c053d79dfec9231508b14de1cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Axonal Transport</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Biological Transport, Active</topic><topic>Dihydrotetrabenazine binding</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Lipid Bilayers - metabolism</topic><topic>Monoamine carrier</topic><topic>Rat sciatic nerve</topic><topic>Rats</topic><topic>Sciatic Nerve - metabolism</topic><topic>Synaptic Vesicles - metabolism</topic><topic>Tetrabenazine - analogs & derivatives</topic><topic>Tetrabenazine - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scherman, D.</creatorcontrib><creatorcontrib>Janssen, P.F.M.</creatorcontrib><creatorcontrib>Laduron, P.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scherman, D.</au><au>Janssen, P.F.M.</au><au>Laduron, P.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Axonal transport of the synaptic vesicle monoamine carrier identified by [ 3H]dihydrotetrabenazine binding in rat sciatic nerve</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1987-06-15</date><risdate>1987</risdate><volume>77</volume><issue>2</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The monoamine carrier of noradrenergic synaptic vesicles was assayed in the rat sciatic nerve by in vitro binding of [
3H]dihydrotetrabenazine. The number of binding sites increased with time on both sides of a ligature, indicating fast anterograde and retrograde axoplasmic transports of comparable amplitude. Anterogradely and retrogradely transported binding sites had similar pharmacological properties, which were characteristic of binding to the monoamine carrier embedded within a lipid bilayer. Contrary to the secreted synaptic vesicle matrix constituents, the intrinsic monoamine carrier assayed by [
3H]dihydrotetrabenazine binding is a marker adapted to retrograde transport studies.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2439958</pmid><doi>10.1016/0304-3940(87)90592-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1987-06, Vol.77 (2), p.231-236 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Animals Axonal Transport Binding Sites Biological and medical sciences Biological Transport, Active Dihydrotetrabenazine binding Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Lipid Bilayers - metabolism Monoamine carrier Rat sciatic nerve Rats Sciatic Nerve - metabolism Synaptic Vesicles - metabolism Tetrabenazine - analogs & derivatives Tetrabenazine - metabolism Vertebrates: nervous system and sense organs |
| title | Axonal transport of the synaptic vesicle monoamine carrier identified by [ 3H]dihydrotetrabenazine binding in rat sciatic nerve |
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