Periodic acid-Schiff-negative granulomatous lymphadenopathy in patients with Whipple's disease. Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy
The diagnosis of Whipple's disease in a 58-year-old man was based on the finding of periodic acid-Schiff (PAS)-positive foamy macrophages on duodenal biopsy and demonstration of the typical bacilliform bodies by electron microscopy. The patient also had generalized peripheral lymphadenopathy wi...
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| Veröffentlicht in: | The American journal of medicine 1987-07, Vol.83 (1), p.165-170 |
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| container_title | The American journal of medicine |
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| creator | Wilcox, G M Tronic, B S Schecter, D J Arron, M J Righi, D F Weiner, N J |
| description | The diagnosis of Whipple's disease in a 58-year-old man was based on the finding of periodic acid-Schiff (PAS)-positive foamy macrophages on duodenal biopsy and demonstration of the typical bacilliform bodies by electron microscopy. The patient also had generalized peripheral lymphadenopathy with lymph node biopsy showing PAS-negative noncaseating granulomas. Electron microscopic examination of the lymph node specimen demonstrated a small number of typical bacilliform bodies with localization specifically to the granulomas in the lymph node. This finding of bacilliform bodies within PAS-negative noncaseating granulomas has not been reported previously. Localization of the Whipple bacillus specifically to noncaseating granulomas suggests that some patients with the disease may manifest a delayed hypersensitivity reaction to the bacillus. |
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Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Wilcox, G M ; Tronic, B S ; Schecter, D J ; Arron, M J ; Righi, D F ; Weiner, N J</creator><creatorcontrib>Wilcox, G M ; Tronic, B S ; Schecter, D J ; Arron, M J ; Righi, D F ; Weiner, N J</creatorcontrib><description>The diagnosis of Whipple's disease in a 58-year-old man was based on the finding of periodic acid-Schiff (PAS)-positive foamy macrophages on duodenal biopsy and demonstration of the typical bacilliform bodies by electron microscopy. The patient also had generalized peripheral lymphadenopathy with lymph node biopsy showing PAS-negative noncaseating granulomas. Electron microscopic examination of the lymph node specimen demonstrated a small number of typical bacilliform bodies with localization specifically to the granulomas in the lymph node. This finding of bacilliform bodies within PAS-negative noncaseating granulomas has not been reported previously. Localization of the Whipple bacillus specifically to noncaseating granulomas suggests that some patients with the disease may manifest a delayed hypersensitivity reaction to the bacillus.</description><identifier>ISSN: 0002-9343</identifier><identifier>PMID: 2440303</identifier><language>eng</language><publisher>United States</publisher><subject>Biopsy ; Bone Marrow - metabolism ; Bone Marrow - ultrastructure ; Duodenum - metabolism ; Duodenum - ultrastructure ; Granuloma - diagnosis ; Granuloma - metabolism ; Granuloma - pathology ; Humans ; Lymph Nodes - metabolism ; Lymph Nodes - ultrastructure ; Lymphatic Diseases - diagnosis ; Lymphatic Diseases - metabolism ; Lymphatic Diseases - pathology ; Macrophages - metabolism ; Macrophages - ultrastructure ; Male ; Microscopy, Electron ; Middle Aged ; Periodic Acid-Schiff Reaction ; Whipple Disease - diagnosis ; Whipple Disease - metabolism ; Whipple Disease - pathology</subject><ispartof>The American journal of medicine, 1987-07, Vol.83 (1), p.165-170</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2440303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilcox, G M</creatorcontrib><creatorcontrib>Tronic, B S</creatorcontrib><creatorcontrib>Schecter, D J</creatorcontrib><creatorcontrib>Arron, M J</creatorcontrib><creatorcontrib>Righi, D F</creatorcontrib><creatorcontrib>Weiner, N J</creatorcontrib><title>Periodic acid-Schiff-negative granulomatous lymphadenopathy in patients with Whipple's disease. Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>The diagnosis of Whipple's disease in a 58-year-old man was based on the finding of periodic acid-Schiff (PAS)-positive foamy macrophages on duodenal biopsy and demonstration of the typical bacilliform bodies by electron microscopy. The patient also had generalized peripheral lymphadenopathy with lymph node biopsy showing PAS-negative noncaseating granulomas. Electron microscopic examination of the lymph node specimen demonstrated a small number of typical bacilliform bodies with localization specifically to the granulomas in the lymph node. This finding of bacilliform bodies within PAS-negative noncaseating granulomas has not been reported previously. Localization of the Whipple bacillus specifically to noncaseating granulomas suggests that some patients with the disease may manifest a delayed hypersensitivity reaction to the bacillus.</description><subject>Biopsy</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow - ultrastructure</subject><subject>Duodenum - metabolism</subject><subject>Duodenum - ultrastructure</subject><subject>Granuloma - diagnosis</subject><subject>Granuloma - metabolism</subject><subject>Granuloma - pathology</subject><subject>Humans</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - ultrastructure</subject><subject>Lymphatic Diseases - diagnosis</subject><subject>Lymphatic Diseases - metabolism</subject><subject>Lymphatic Diseases - pathology</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - ultrastructure</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Periodic Acid-Schiff Reaction</subject><subject>Whipple Disease - diagnosis</subject><subject>Whipple Disease - metabolism</subject><subject>Whipple Disease - pathology</subject><issn>0002-9343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1KxDAUhbtQxnH0EYSsdFVJJ23TLmXwDwYUHHBZbpPbaSRNYpMq9cF8PgOOuLrnwnfOgXOULCml67RmOTtJTr1_iy-ti3KRLNZ5Thlly-T7GUdlpRIEhJLpi-hV16UG9xDUB5L9CGbSdoBgJ0_0PLgeJBrrIPQzUYZEodAETz5V6Mlrr5zTeOWJVB7B4zXZWgFafUXMGmI7Enr8w0gbO7WOwcESY42IhsiZ_X-tJ-1MUKMIY7QPSozWC-vms-S4A-3x_HBXye7udrd5SLdP94-bm23qCsZSySqAokSkdZdzVmaCF9hWshAdIs-qtuAV1FkLtRTQ5ZILBlBXlFWZaCXN2Sq5_I11o32f0IdmUF6g1mAwDtJwXtI8q7MIXhzAqR1QNm5UA4xzc9iZ_QAv738n</recordid><startdate>198707</startdate><enddate>198707</enddate><creator>Wilcox, G M</creator><creator>Tronic, B S</creator><creator>Schecter, D J</creator><creator>Arron, M J</creator><creator>Righi, D F</creator><creator>Weiner, N J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198707</creationdate><title>Periodic acid-Schiff-negative granulomatous lymphadenopathy in patients with Whipple's disease. Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy</title><author>Wilcox, G M ; Tronic, B S ; Schecter, D J ; Arron, M J ; Righi, D F ; Weiner, N J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p533-d38aa56ee09f47361c75eb8d5cfee718b578a91ba9dcaf4d7c3aa980381cbd043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biopsy</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Marrow - ultrastructure</topic><topic>Duodenum - metabolism</topic><topic>Duodenum - ultrastructure</topic><topic>Granuloma - diagnosis</topic><topic>Granuloma - metabolism</topic><topic>Granuloma - pathology</topic><topic>Humans</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - ultrastructure</topic><topic>Lymphatic Diseases - diagnosis</topic><topic>Lymphatic Diseases - metabolism</topic><topic>Lymphatic Diseases - pathology</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - ultrastructure</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Periodic Acid-Schiff Reaction</topic><topic>Whipple Disease - diagnosis</topic><topic>Whipple Disease - metabolism</topic><topic>Whipple Disease - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilcox, G M</creatorcontrib><creatorcontrib>Tronic, B S</creatorcontrib><creatorcontrib>Schecter, D J</creatorcontrib><creatorcontrib>Arron, M J</creatorcontrib><creatorcontrib>Righi, D F</creatorcontrib><creatorcontrib>Weiner, N J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilcox, G M</au><au>Tronic, B S</au><au>Schecter, D J</au><au>Arron, M J</au><au>Righi, D F</au><au>Weiner, N J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodic acid-Schiff-negative granulomatous lymphadenopathy in patients with Whipple's disease. Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1987-07</date><risdate>1987</risdate><volume>83</volume><issue>1</issue><spage>165</spage><epage>170</epage><pages>165-170</pages><issn>0002-9343</issn><abstract>The diagnosis of Whipple's disease in a 58-year-old man was based on the finding of periodic acid-Schiff (PAS)-positive foamy macrophages on duodenal biopsy and demonstration of the typical bacilliform bodies by electron microscopy. The patient also had generalized peripheral lymphadenopathy with lymph node biopsy showing PAS-negative noncaseating granulomas. Electron microscopic examination of the lymph node specimen demonstrated a small number of typical bacilliform bodies with localization specifically to the granulomas in the lymph node. This finding of bacilliform bodies within PAS-negative noncaseating granulomas has not been reported previously. Localization of the Whipple bacillus specifically to noncaseating granulomas suggests that some patients with the disease may manifest a delayed hypersensitivity reaction to the bacillus.</abstract><cop>United States</cop><pmid>2440303</pmid><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1987-07, Vol.83 (1), p.165-170 |
| issn | 0002-9343 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biopsy Bone Marrow - metabolism Bone Marrow - ultrastructure Duodenum - metabolism Duodenum - ultrastructure Granuloma - diagnosis Granuloma - metabolism Granuloma - pathology Humans Lymph Nodes - metabolism Lymph Nodes - ultrastructure Lymphatic Diseases - diagnosis Lymphatic Diseases - metabolism Lymphatic Diseases - pathology Macrophages - metabolism Macrophages - ultrastructure Male Microscopy, Electron Middle Aged Periodic Acid-Schiff Reaction Whipple Disease - diagnosis Whipple Disease - metabolism Whipple Disease - pathology |
| title | Periodic acid-Schiff-negative granulomatous lymphadenopathy in patients with Whipple's disease. Localization of the Whipple bacillus to noncaseating granulomas by electron microscopy |
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