Peripheral blood remission of hairy cell leukemia after transfusion hepatitis
Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurren...
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| Veröffentlicht in: | American journal of hematology 1987-07, Vol.25 (3), p.277-284 |
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| container_end_page | 284 |
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| container_start_page | 277 |
| container_title | American journal of hematology |
| container_volume | 25 |
| creator | Keefer, Michael J. Weber, Maril J. Bottomley, Sylvia S. Solanki, Dilip L. Hosty, Thomas A. |
| description | Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and transfusiondependent anemia after splenectomy. Each subsequently acquired transfusion hepatitis and in two patients marked hematologic improvement was noted within 2 months. Complete peripheral blood remission occurred within 17 months in all patients although bone marrow infiltration with hairy cells persisted. One patient remains in remission for 12 years; the other two succumbed to infectious illnesses but with normal blood counts. The mechanism by which hepatitis virus induces hematologic recovery in patients with hairy cell leukemia is unknown but may involve augmentation of the interferon system. |
| doi_str_mv | 10.1002/ajh.2830250307 |
| format | Article |
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Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and transfusiondependent anemia after splenectomy. Each subsequently acquired transfusion hepatitis and in two patients marked hematologic improvement was noted within 2 months. Complete peripheral blood remission occurred within 17 months in all patients although bone marrow infiltration with hairy cells persisted. One patient remains in remission for 12 years; the other two succumbed to infectious illnesses but with normal blood counts. The mechanism by which hepatitis virus induces hematologic recovery in patients with hairy cell leukemia is unknown but may involve augmentation of the interferon system.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830250307</identifier><identifier>PMID: 3111250</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Blood Cell Count ; Erythrocyte Transfusion ; Female ; Granulocytes - cytology ; Hematologic and hematopoietic diseases ; hepatitis ; Hepatitis - etiology ; Hepatitis - transmission ; Hepatitis B - transmission ; Hepatitis C - transmission ; Humans ; inteferon ; Leukemia, Hairy Cell - blood ; Leukemia, Hairy Cell - complications ; Leukemia, Hairy Cell - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; leukemic reticuloendotheliosis ; Male ; Medical sciences ; Middle Aged ; Remission Induction ; Splenectomy ; Transfusion Reaction</subject><ispartof>American journal of hematology, 1987-07, Vol.25 (3), p.277-284</ispartof><rights>Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-2ff383f12538c9e17dcec2e7cfa11630d8d530e4202fc398335d00f79588aff33</citedby><cites>FETCH-LOGICAL-c4647-2ff383f12538c9e17dcec2e7cfa11630d8d530e4202fc398335d00f79588aff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.2830250307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.2830250307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8276351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3111250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keefer, Michael J.</creatorcontrib><creatorcontrib>Weber, Maril J.</creatorcontrib><creatorcontrib>Bottomley, Sylvia S.</creatorcontrib><creatorcontrib>Solanki, Dilip L.</creatorcontrib><creatorcontrib>Hosty, Thomas A.</creatorcontrib><title>Peripheral blood remission of hairy cell leukemia after transfusion hepatitis</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and transfusiondependent anemia after splenectomy. Each subsequently acquired transfusion hepatitis and in two patients marked hematologic improvement was noted within 2 months. Complete peripheral blood remission occurred within 17 months in all patients although bone marrow infiltration with hairy cells persisted. One patient remains in remission for 12 years; the other two succumbed to infectious illnesses but with normal blood counts. The mechanism by which hepatitis virus induces hematologic recovery in patients with hairy cell leukemia is unknown but may involve augmentation of the interferon system.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Erythrocyte Transfusion</subject><subject>Female</subject><subject>Granulocytes - cytology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>hepatitis</subject><subject>Hepatitis - etiology</subject><subject>Hepatitis - transmission</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis C - transmission</subject><subject>Humans</subject><subject>inteferon</subject><subject>Leukemia, Hairy Cell - blood</subject><subject>Leukemia, Hairy Cell - complications</subject><subject>Leukemia, Hairy Cell - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>leukemic reticuloendotheliosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Remission Induction</subject><subject>Splenectomy</subject><subject>Transfusion Reaction</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EKqWwsiF5QGwpZzsfzlhVQEFFMMAcuc5ZcUmbYidC_e9xaVTYmO6k93t3T4-QSwZjBsBv1bIacymAJyAgOyJDBnkayTThx2QIImVhh_yUnHm_BGAsljAgA8EYC44heX5FZzcVOlXTRd00JXW4st7bZk0bQytl3ZZqrGtaY_cRJEWVadHR1qm1N90PWOFGtba1_pycGFV7vOjniLzf371NZ9H85eFxOplHOk7jLOLGCClMSCCkzpFlpUbNMdNGMZYKKGWZCMCYAzda5FKIpAQwWZ5IqYJXjMjN_u7GNZ8d-rYImXcp1RqbzhdZloJgeRrA8R7UrvHeoSk2zq6U2xYMil1_Reiv-O0vGK76y91iheUB7wsL-nWvK69VbUIL2voDJnmWioQFLN9jX7bG7T9Pi8nT7E-Eb4SYiK0</recordid><startdate>198707</startdate><enddate>198707</enddate><creator>Keefer, Michael J.</creator><creator>Weber, Maril J.</creator><creator>Bottomley, Sylvia S.</creator><creator>Solanki, Dilip L.</creator><creator>Hosty, Thomas A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198707</creationdate><title>Peripheral blood remission of hairy cell leukemia after transfusion hepatitis</title><author>Keefer, Michael J. ; Weber, Maril J. ; Bottomley, Sylvia S. ; Solanki, Dilip L. ; Hosty, Thomas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-2ff383f12538c9e17dcec2e7cfa11630d8d530e4202fc398335d00f79588aff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>Erythrocyte Transfusion</topic><topic>Female</topic><topic>Granulocytes - cytology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>hepatitis</topic><topic>Hepatitis - etiology</topic><topic>Hepatitis - transmission</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis C - transmission</topic><topic>Humans</topic><topic>inteferon</topic><topic>Leukemia, Hairy Cell - blood</topic><topic>Leukemia, Hairy Cell - complications</topic><topic>Leukemia, Hairy Cell - therapy</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>leukemic reticuloendotheliosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Remission Induction</topic><topic>Splenectomy</topic><topic>Transfusion Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keefer, Michael J.</creatorcontrib><creatorcontrib>Weber, Maril J.</creatorcontrib><creatorcontrib>Bottomley, Sylvia S.</creatorcontrib><creatorcontrib>Solanki, Dilip L.</creatorcontrib><creatorcontrib>Hosty, Thomas A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keefer, Michael J.</au><au>Weber, Maril J.</au><au>Bottomley, Sylvia S.</au><au>Solanki, Dilip L.</au><au>Hosty, Thomas A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral blood remission of hairy cell leukemia after transfusion hepatitis</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1987-07</date><risdate>1987</risdate><volume>25</volume><issue>3</issue><spage>277</spage><epage>284</epage><pages>277-284</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and transfusiondependent anemia after splenectomy. Each subsequently acquired transfusion hepatitis and in two patients marked hematologic improvement was noted within 2 months. Complete peripheral blood remission occurred within 17 months in all patients although bone marrow infiltration with hairy cells persisted. One patient remains in remission for 12 years; the other two succumbed to infectious illnesses but with normal blood counts. The mechanism by which hepatitis virus induces hematologic recovery in patients with hairy cell leukemia is unknown but may involve augmentation of the interferon system.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3111250</pmid><doi>10.1002/ajh.2830250307</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of hematology, 1987-07, Vol.25 (3), p.277-284 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences Blood Cell Count Erythrocyte Transfusion Female Granulocytes - cytology Hematologic and hematopoietic diseases hepatitis Hepatitis - etiology Hepatitis - transmission Hepatitis B - transmission Hepatitis C - transmission Humans inteferon Leukemia, Hairy Cell - blood Leukemia, Hairy Cell - complications Leukemia, Hairy Cell - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis leukemic reticuloendotheliosis Male Medical sciences Middle Aged Remission Induction Splenectomy Transfusion Reaction |
| title | Peripheral blood remission of hairy cell leukemia after transfusion hepatitis |
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