Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid : implications for photodynamic treatment

Clinical trials of topical ALA in photodynamic therapy (PDT) of basal cell carcinoma (BCC) show significant recurrence rates. Exogenous 5-aminolevulinic acid (ALA) is converted by intracellular enzymes to photoactive protoporphyrin IX (PpIX) in human tissues. PpIX generates cytotoxic singlet oxygen...

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Veröffentlicht in:	Archives of Dermatological Research 1995-09, Vol.287 (7), p.665-674
Hauptverfasser:	MARTIN, A, TOPE, W. D, GREVELINK, J. M, STARR, J. C, FEWKES, J. L, FLOTTE, T. J, DEUTSCH, T. F, ANDERSON, R. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Adult Aminolevulinic Acid - administration & dosage Biological and medical sciences Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Female Humans Male Medical sciences Microscopy, Fluorescence Pharmacology. Drug treatments Photochemotherapy Protoporphyrins - metabolism Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin, nail, hair, dermoskeleton
Online-Zugang:	Volltext
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