A new class of synthetic antibacterials acting on lipopolysaccharide biosynthesis

Although there is a need for antibacterial agents that act only on Gram-negative bacteria, there are at present few such compounds. The 2-deoxy analogue of beta-KDO (3-deoxy-beta-D-manno-2-octulopyranosonic acid) is a potent inhibitor of a key enzyme (CMP-KDO synthetase) in lipopolysaccharide biosyn...

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Veröffentlicht in:	Nature (London) 1987-06, Vol.327 (6124), p.730-732
Hauptverfasser:	HAMMOND, S. M, CLAESSON, A, JANSSON, A. M, LARSSON, L. G, PRING, B. C, TOWN, C. M, EKSTROM, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Bacteria Biological and medical sciences Biosynthesis Dipeptides - metabolism Escherichia coli - drug effects Escherichia coli - metabolism Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - metabolism Lipopolysaccharides - biosynthesis Medical research Medical sciences Nucleotidyltransferases - antagonists & inhibitors Pharmacology. Drug treatments Sugar Acids - metabolism Sugar Acids - pharmacology Technology
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