Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies

Xenotransplantation of tissues between discordant species such as pig into human is not yet feasible due to the problem of hyperacute rejection. This rapid response to xenogeneic tissue is mediated by natural antibodies that react with antigens on the xenograft. A number of xenoantigens consist of c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 1995-10, Vol.60 (8), p.841-847
Hauptverfasser:	LAVECCHIO, J. A, DUNNE, A. D, EDGE, A. S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-N-Acetylgalactosaminidase Animals Antigen-Antibody Complex Biological and medical sciences Cells, Cultured Endothelium, Vascular - immunology Epitopes - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Haplorhini Hexosaminidases - pharmacology Humans Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Swine Tissue, organ and graft immunology Transplantation, Heterologous - immunology Trisaccharides - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!