EVIDENCE THAT T-KININ DOES NOT MEDIATE PAW SWELLING INDUCED BY CARRAGEENIN : STUDIES WITH PLASMA HIGH MOLECULAR WEIGHT KININOGEN AND LOW MOLECULAR WEIGHT KININOGEN DEFICIENT RATS
Paw swelling induced by carrageenin was compared in Brown Norway Kitasato rats (normal) and Brown Norway Kitasato rats, deficient in HMW and LMW kininogens. The increase in the paw volume of the former after the carrageenin injection was about 50-70% of the initial volume, whereas that of the latter...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1987/03/25, Vol.35(3), pp.1315-1318 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Oh-ishi, Sachiko Hayashi, Izumi Utsunomiya, Iku Hayashi, Masahiko Yamaki, Kohji Yamasu, Akiko Nakano, Takeshi |
| description | Paw swelling induced by carrageenin was compared in Brown Norway Kitasato rats (normal) and Brown Norway Kitasato rats, deficient in HMW and LMW kininogens. The increase in the paw volume of the former after the carrageenin injection was about 50-70% of the initial volume, whereas that of the latter was about 10%. Pretreatment with captopril, a kininase inhibitor, enhanced the edema significantly in the former but had no effect in the latter. The T-kininogen level in the plasmas of both strains increased gradually and peaked on the 2nd day at 10 times of the control level. But the paw swelling peaked at 4-5 hours after the carrageenin injection. These results indicate that bradykinin but not T-kinin induces paw swelling by plasma exudation. |
| doi_str_mv | 10.1248/cpb.35.1315 |
| format | Article |
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The increase in the paw volume of the former after the carrageenin injection was about 50-70% of the initial volume, whereas that of the latter was about 10%. Pretreatment with captopril, a kininase inhibitor, enhanced the edema significantly in the former but had no effect in the latter. The T-kininogen level in the plasmas of both strains increased gradually and peaked on the 2nd day at 10 times of the control level. But the paw swelling peaked at 4-5 hours after the carrageenin injection. These results indicate that bradykinin but not T-kinin induces paw swelling by plasma exudation.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.35.1315</identifier><identifier>PMID: 3607957</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; Bradykinin - analogs & derivatives ; Bradykinin - physiology ; captopril ; Carrageenan ; carrageenin ; Edema - physiopathology ; Fundamental and applied biological sciences. Psychology ; HMW-kininogen ; Inflammation ; Kininogens - blood ; Kininogens - deficiency ; Molecular and cellular biology ; Molecular Weight ; paw edema ; Rats ; T-kinin ; T-kininogen</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1987/03/25, Vol.35(3), pp.1315-1318</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4215-f5a65df414b6b0e2dd38d19dc2726301870ccb437c5c44052f3a108f293e0a7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7612512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3607957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh-ishi, Sachiko</creatorcontrib><creatorcontrib>Hayashi, Izumi</creatorcontrib><creatorcontrib>Utsunomiya, Iku</creatorcontrib><creatorcontrib>Hayashi, Masahiko</creatorcontrib><creatorcontrib>Yamaki, Kohji</creatorcontrib><creatorcontrib>Yamasu, Akiko</creatorcontrib><creatorcontrib>Nakano, Takeshi</creatorcontrib><title>EVIDENCE THAT T-KININ DOES NOT MEDIATE PAW SWELLING INDUCED BY CARRAGEENIN : STUDIES WITH PLASMA HIGH MOLECULAR WEIGHT KININOGEN AND LOW MOLECULAR WEIGHT KININOGEN DEFICIENT RATS</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Paw swelling induced by carrageenin was compared in Brown Norway Kitasato rats (normal) and Brown Norway Kitasato rats, deficient in HMW and LMW kininogens. The increase in the paw volume of the former after the carrageenin injection was about 50-70% of the initial volume, whereas that of the latter was about 10%. Pretreatment with captopril, a kininase inhibitor, enhanced the edema significantly in the former but had no effect in the latter. The T-kininogen level in the plasmas of both strains increased gradually and peaked on the 2nd day at 10 times of the control level. But the paw swelling peaked at 4-5 hours after the carrageenin injection. These results indicate that bradykinin but not T-kinin induces paw swelling by plasma exudation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bradykinin - analogs & derivatives</subject><subject>Bradykinin - physiology</subject><subject>captopril</subject><subject>Carrageenan</subject><subject>carrageenin</subject><subject>Edema - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HMW-kininogen</subject><subject>Inflammation</subject><subject>Kininogens - blood</subject><subject>Kininogens - deficiency</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>paw edema</subject><subject>Rats</subject><subject>T-kinin</subject><subject>T-kininogen</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuv0zAQhS0EupTCijWSF4gNSvEjjht2volvY5EmV41LxSpyHQd61Rdxu-Bv8QtJaFV2bGY0Ot_MkeYA8BajCSbh9JM9rieUTTDF7BkYYRrygBFCn4MRQigOCI3oS_DK-yeECEOc3oE7GiEeMz4Cv-VXlcoikVBnQkMdfFGFKmBaygoWpYZzmSqhJXwUK1itZJ6rYgZVkS4TmcL7bzARi4WYSTksfYaVXqaq31wpncHHXFRzATM1y-C8zGWyzMUCrmQ_a_jXppzJAooihXm5-h-SygeVKFlouBC6eg1etGbr3ZtrH4Plg9RJFuTlTCUiD2xIMAtaZiLWtCEO19EaOdI0dNrguLGEk4giPOXI2nVIuWU2DBEjLTUYTVsSU4cMd3QMPlzuHrvDz7Pzp3q38dZtt2bvDmdfc85ijvvnjsHHC2i7g_eda-tjt9mZ7leNUT0kVPcJ1ZTVQ0I9_e569rzeuebGXiPp9fdX3Xhrtm1n9nbjbxiPMGGY9Fh6wZ78yXx3N910p43dusESx2w62NJLGdz_yT9MV7s9_QP5gaGi</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Oh-ishi, Sachiko</creator><creator>Hayashi, Izumi</creator><creator>Utsunomiya, Iku</creator><creator>Hayashi, Masahiko</creator><creator>Yamaki, Kohji</creator><creator>Yamasu, Akiko</creator><creator>Nakano, Takeshi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>EVIDENCE THAT T-KININ DOES NOT MEDIATE PAW SWELLING INDUCED BY CARRAGEENIN : STUDIES WITH PLASMA HIGH MOLECULAR WEIGHT KININOGEN AND LOW MOLECULAR WEIGHT KININOGEN DEFICIENT RATS</title><author>Oh-ishi, Sachiko ; Hayashi, Izumi ; Utsunomiya, Iku ; Hayashi, Masahiko ; Yamaki, Kohji ; Yamasu, Akiko ; Nakano, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4215-f5a65df414b6b0e2dd38d19dc2726301870ccb437c5c44052f3a108f293e0a7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bradykinin - analogs & derivatives</topic><topic>Bradykinin - physiology</topic><topic>captopril</topic><topic>Carrageenan</topic><topic>carrageenin</topic><topic>Edema - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HMW-kininogen</topic><topic>Inflammation</topic><topic>Kininogens - blood</topic><topic>Kininogens - deficiency</topic><topic>Molecular and cellular biology</topic><topic>Molecular Weight</topic><topic>paw edema</topic><topic>Rats</topic><topic>T-kinin</topic><topic>T-kininogen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh-ishi, Sachiko</creatorcontrib><creatorcontrib>Hayashi, Izumi</creatorcontrib><creatorcontrib>Utsunomiya, Iku</creatorcontrib><creatorcontrib>Hayashi, Masahiko</creatorcontrib><creatorcontrib>Yamaki, Kohji</creatorcontrib><creatorcontrib>Yamasu, Akiko</creatorcontrib><creatorcontrib>Nakano, Takeshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh-ishi, Sachiko</au><au>Hayashi, Izumi</au><au>Utsunomiya, Iku</au><au>Hayashi, Masahiko</au><au>Yamaki, Kohji</au><au>Yamasu, Akiko</au><au>Nakano, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EVIDENCE THAT T-KININ DOES NOT MEDIATE PAW SWELLING INDUCED BY CARRAGEENIN : STUDIES WITH PLASMA HIGH MOLECULAR WEIGHT KININOGEN AND LOW MOLECULAR WEIGHT KININOGEN DEFICIENT RATS</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1987</date><risdate>1987</risdate><volume>35</volume><issue>3</issue><spage>1315</spage><epage>1318</epage><pages>1315-1318</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Paw swelling induced by carrageenin was compared in Brown Norway Kitasato rats (normal) and Brown Norway Kitasato rats, deficient in HMW and LMW kininogens. The increase in the paw volume of the former after the carrageenin injection was about 50-70% of the initial volume, whereas that of the latter was about 10%. Pretreatment with captopril, a kininase inhibitor, enhanced the edema significantly in the former but had no effect in the latter. The T-kininogen level in the plasmas of both strains increased gradually and peaked on the 2nd day at 10 times of the control level. But the paw swelling peaked at 4-5 hours after the carrageenin injection. These results indicate that bradykinin but not T-kinin induces paw swelling by plasma exudation.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>3607957</pmid><doi>10.1248/cpb.35.1315</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Bradykinin - analogs & derivatives Bradykinin - physiology captopril Carrageenan carrageenin Edema - physiopathology Fundamental and applied biological sciences. Psychology HMW-kininogen Inflammation Kininogens - blood Kininogens - deficiency Molecular and cellular biology Molecular Weight paw edema Rats T-kinin T-kininogen |
| title | EVIDENCE THAT T-KININ DOES NOT MEDIATE PAW SWELLING INDUCED BY CARRAGEENIN : STUDIES WITH PLASMA HIGH MOLECULAR WEIGHT KININOGEN AND LOW MOLECULAR WEIGHT KININOGEN DEFICIENT RATS |
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