Impairment of monocyte lectin-like receptor activity in Type 1 (insulin-dependent) diabetic patients
In order to investigate whether the ability of peripheral blood monocytes to bind bacteria is impaired in diabetes, we studied carbohydrate-binding ("lectin-like") receptors and the receptor for the Fc portion of immunoglobulin on monocytes from 25 male Type 1 (insulin-dependent) diabetic...
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| Veröffentlicht in: | Diabetologia 1987-04, Vol.30 (4), p.228-231 |
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| container_title | Diabetologia |
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| creator | GLASS, E. J STEWART, J MATTHEWS, D. M COLLIER, A CLARKE, B. F WEIR, D. M |
| description | In order to investigate whether the ability of peripheral blood monocytes to bind bacteria is impaired in diabetes, we studied carbohydrate-binding ("lectin-like") receptors and the receptor for the Fc portion of immunoglobulin on monocytes from 25 male Type 1 (insulin-dependent) diabetic patients and 10 age-matched healthy control subjects. Peripheral blood monocytes from the diabetic patients expressed lower levels of "lectin-like" receptors compared to the control subjects, whereas the expression of the receptor for the Fc portion of immunoglobulin was similar in both populations. There was no correlation between the degree of "lectin-like" binding activity and plasma glucose concentration or glycaemic control. Recognition of unopsonized bacteria by the "lectin-like" receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens. |
| doi_str_mv | 10.1007/bf00270420 |
| format | Article |
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Recognition of unopsonized bacteria by the "lectin-like" receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/bf00270420</identifier><identifier>PMID: 3596079</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - immunology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. 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Peripheral blood monocytes from the diabetic patients expressed lower levels of "lectin-like" receptors compared to the control subjects, whereas the expression of the receptor for the Fc portion of immunoglobulin was similar in both populations. There was no correlation between the degree of "lectin-like" binding activity and plasma glucose concentration or glycaemic control. Recognition of unopsonized bacteria by the "lectin-like" receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fructosamine</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hexosamines - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monocytes - immunology</subject><subject>Receptors, Fc - metabolism</subject><subject>Receptors, Mitogen - metabolism</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLJDEUhYOMaPvYuBeyGESF0ptKKjFLFVsFwY2CuyKPWxCt1yRpof-9EXtc3cs5H2fxEXLE4IIBqEvbAdQKRA1bZMEEr6vyX_0hCwBWV-xKvu2SvZTeAYA3Qu6QHd5oCUoviH8cZhPigGOmU0eHaZzcOiPt0eUwVn34QBrR4ZynSE3JPkNe0zDSl_WMlNHTMKZVX0iPM46-zJxRH4zFHBydTQ4lSQdkuzN9wsPN3Sevy7uX24fq6fn-8fb6qXKC8VwZbRBkZxVyq5324EpQG-sF2sYaxZiXUtfCAUghVC2k5t4ow63SNdeS75OTn905Tv9WmHI7hOSw782I0yq1SjW6kY0u4PkP6OKUUsSunWMYTFy3DNpvpe3N8r_SAh9vVld2QP-LbhyW_u-mN8mZvotmdCH9YoprxkTDvwCZ8H5U</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>GLASS, E. 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Target tissue resistance</topic><topic>Fructosamine</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hexosamines - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monocytes - immunology</topic><topic>Receptors, Fc - metabolism</topic><topic>Receptors, Mitogen - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GLASS, E. J</creatorcontrib><creatorcontrib>STEWART, J</creatorcontrib><creatorcontrib>MATTHEWS, D. M</creatorcontrib><creatorcontrib>COLLIER, A</creatorcontrib><creatorcontrib>CLARKE, B. F</creatorcontrib><creatorcontrib>WEIR, D. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impairment of monocyte lectin-like receptor activity in Type 1 (insulin-dependent) diabetic patients</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>30</volume><issue>4</issue><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>In order to investigate whether the ability of peripheral blood monocytes to bind bacteria is impaired in diabetes, we studied carbohydrate-binding ("lectin-like") receptors and the receptor for the Fc portion of immunoglobulin on monocytes from 25 male Type 1 (insulin-dependent) diabetic patients and 10 age-matched healthy control subjects. Peripheral blood monocytes from the diabetic patients expressed lower levels of "lectin-like" receptors compared to the control subjects, whereas the expression of the receptor for the Fc portion of immunoglobulin was similar in both populations. There was no correlation between the degree of "lectin-like" binding activity and plasma glucose concentration or glycaemic control. Recognition of unopsonized bacteria by the "lectin-like" receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3596079</pmid><doi>10.1007/bf00270420</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 1987-04, Vol.30 (4), p.228-231 |
| issn | 0012-186X 1432-0428 |
| language | eng |
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| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fructosamine Glycated Hemoglobin A - metabolism Hexosamines - blood Humans Male Medical sciences Monocytes - immunology Receptors, Fc - metabolism Receptors, Mitogen - metabolism |
| title | Impairment of monocyte lectin-like receptor activity in Type 1 (insulin-dependent) diabetic patients |
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