Sucrose analgesia» and diphtheria-tetanus-pertussis immunizations at 2 and 4 months
In human newborns, small amounts of sucrose reduce crying with procedural pain by about 50%. To determine whether "sucrose analgesia" could be extended to painful procedures beyond the newborn period, 57 infants were randomly assigned to receive three 250-microliters doses of 50% sucrose s...
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| Veröffentlicht in: | Journal of developmental and behavioral pediatrics 1995-08, Vol.16 (4), p.220-225 |
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| container_issue | 4 |
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| container_title | Journal of developmental and behavioral pediatrics |
| container_volume | 16 |
| creator | BARR, R. G YOUNG, S. N WRIGHT, J. H CASSIDY, K.-L HENDRICKS, L BEDARD, Y YAREMKO, J LEDUC, D TREHERNE, S |
| description | In human newborns, small amounts of sucrose reduce crying with procedural pain by about 50%. To determine whether "sucrose analgesia" could be extended to painful procedures beyond the newborn period, 57 infants were randomly assigned to receive three 250-microliters doses of 50% sucrose solution (g/100 mL) or water before their diphtheria-tetanus-pertussis immunizations at 2 and 4 months of age. Crying during and after injection was measured separately to determine whether sucrose modified crying during the noxious stimulus, recovery from the stimulus, or both. Sucrose was effective in reducing crying only from 83 to 69%, and the reduction was limited to the postinjection period. We conclude that, although sucrose continues to have some effect beyond the newborn period, the effect is limited to recovery from the noxious stimulus, is clinically modest, and is probably smaller than in the newborn period. |
| doi_str_mv | 10.1097/00004703-199508000-00002 |
| format | Article |
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G ; YOUNG, S. N ; WRIGHT, J. H ; CASSIDY, K.-L ; HENDRICKS, L ; BEDARD, Y ; YAREMKO, J ; LEDUC, D ; TREHERNE, S</creator><creatorcontrib>BARR, R. G ; YOUNG, S. N ; WRIGHT, J. H ; CASSIDY, K.-L ; HENDRICKS, L ; BEDARD, Y ; YAREMKO, J ; LEDUC, D ; TREHERNE, S</creatorcontrib><description>In human newborns, small amounts of sucrose reduce crying with procedural pain by about 50%. To determine whether "sucrose analgesia" could be extended to painful procedures beyond the newborn period, 57 infants were randomly assigned to receive three 250-microliters doses of 50% sucrose solution (g/100 mL) or water before their diphtheria-tetanus-pertussis immunizations at 2 and 4 months of age. Crying during and after injection was measured separately to determine whether sucrose modified crying during the noxious stimulus, recovery from the stimulus, or both. Sucrose was effective in reducing crying only from 83 to 69%, and the reduction was limited to the postinjection period. We conclude that, although sucrose continues to have some effect beyond the newborn period, the effect is limited to recovery from the noxious stimulus, is clinically modest, and is probably smaller than in the newborn period.</description><identifier>ISSN: 0196-206X</identifier><identifier>EISSN: 1536-7312</identifier><identifier>DOI: 10.1097/00004703-199508000-00002</identifier><identifier>PMID: 7593655</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject><![CDATA[Biological and medical sciences ; Crying ; Diphtheria - immunology ; Diphtheria - prevention & control ; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Longitudinal Studies ; Miscellaneous ; Pain - prevention & control ; Psychology and medicine ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Stress, Psychological - psychology ; Sucrose - administration & dosage ; Tetanus - immunology ; Tetanus - prevention & control ; Vaccination ; Whooping Cough - immunology ; Whooping Cough - prevention & control]]></subject><ispartof>Journal of developmental and behavioral pediatrics, 1995-08, Vol.16 (4), p.220-225</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-30b4ffdb345f492fd725e82937fde148927ae97c1ec36300eb3a4597dacbef963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3637888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7593655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARR, R. 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Crying during and after injection was measured separately to determine whether sucrose modified crying during the noxious stimulus, recovery from the stimulus, or both. Sucrose was effective in reducing crying only from 83 to 69%, and the reduction was limited to the postinjection period. We conclude that, although sucrose continues to have some effect beyond the newborn period, the effect is limited to recovery from the noxious stimulus, is clinically modest, and is probably smaller than in the newborn period.</description><subject>Biological and medical sciences</subject><subject>Crying</subject><subject>Diphtheria - immunology</subject><subject>Diphtheria - prevention & control</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Longitudinal Studies</subject><subject>Miscellaneous</subject><subject>Pain - prevention & control</subject><subject>Psychology and medicine</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Stress, Psychological - psychology</subject><subject>Sucrose - administration & dosage</subject><subject>Tetanus - immunology</subject><subject>Tetanus - prevention & control</subject><subject>Vaccination</subject><subject>Whooping Cough - immunology</subject><subject>Whooping Cough - prevention & control</subject><issn>0196-206X</issn><issn>1536-7312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlOwzAQtRColMInIOWAuBm8xHF8RIhNqsSBInGLnGRMjbKRcQ7wa9z4MpK2dC6zvTfLIyTi7Iozo6_ZaLFmknJjFEvHjE4lcUDmXMmEasnFIZkzbhIqWPJ2TE4QPyYEN3JGZloZmSg1J6uXoehbhMg2tnoH9Pb3Z4zLqPTdOqyh95YGCLYZkHbQhwHRY-Tremj8tw2-bTCyIRIbThzVbRPWeEqOnK0QznZ-QV7v71a3j3T5_PB0e7OkhZQmUMny2Lkyl7FysRGu1EJBKozUrgQep0ZoC0YXHAqZSMYglzZWRpe2yMGZRC7I5XZu17efA2DIao8FVJVtoB0w09ObxogRmG6B06_Yg8u63te2_8o4yyZBs39Bs72gm9JEPd_tGPIayj1xp-DYv9j1LRa2cr1tCo972Hi4TtNU_gF5S38t</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>BARR, R. 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H ; CASSIDY, K.-L ; HENDRICKS, L ; BEDARD, Y ; YAREMKO, J ; LEDUC, D ; TREHERNE, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-30b4ffdb345f492fd725e82937fde148927ae97c1ec36300eb3a4597dacbef963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Crying</topic><topic>Diphtheria - immunology</topic><topic>Diphtheria - prevention & control</topic><topic>Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Longitudinal Studies</topic><topic>Miscellaneous</topic><topic>Pain - prevention & control</topic><topic>Psychology and medicine</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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H</creatorcontrib><creatorcontrib>CASSIDY, K.-L</creatorcontrib><creatorcontrib>HENDRICKS, L</creatorcontrib><creatorcontrib>BEDARD, Y</creatorcontrib><creatorcontrib>YAREMKO, J</creatorcontrib><creatorcontrib>LEDUC, D</creatorcontrib><creatorcontrib>TREHERNE, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of developmental and behavioral pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARR, R. G</au><au>YOUNG, S. N</au><au>WRIGHT, J. 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Crying during and after injection was measured separately to determine whether sucrose modified crying during the noxious stimulus, recovery from the stimulus, or both. Sucrose was effective in reducing crying only from 83 to 69%, and the reduction was limited to the postinjection period. We conclude that, although sucrose continues to have some effect beyond the newborn period, the effect is limited to recovery from the noxious stimulus, is clinically modest, and is probably smaller than in the newborn period.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7593655</pmid><doi>10.1097/00004703-199508000-00002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of developmental and behavioral pediatrics, 1995-08, Vol.16 (4), p.220-225 |
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| language | eng |
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| subjects | Biological and medical sciences Crying Diphtheria - immunology Diphtheria - prevention & control Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage Fundamental and applied biological sciences. Psychology Humans Infant Longitudinal Studies Miscellaneous Pain - prevention & control Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Stress, Psychological - psychology Sucrose - administration & dosage Tetanus - immunology Tetanus - prevention & control Vaccination Whooping Cough - immunology Whooping Cough - prevention & control |
| title | Sucrose analgesia» and diphtheria-tetanus-pertussis immunizations at 2 and 4 months |
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