Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a...

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Veröffentlicht in:	Nature (London) 1987-07, Vol.328 (6127), p.257-259
Hauptverfasser:	HERRINGTON, D. A, CLYDE, D. F, NARDIN, E, NUSSENZWEIG, R. S, NUSSENZWEIG, V, HOLLINGDALE, M. R, LEVINE, M. M, LOSONSKY, G, CORTESIA, M, MURPHY, J. R, DAVIS, J, SHAHIDA BAQAR, FELIX, A. M, HEIMER, E. P, GILLESSEN, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Animals Antibody Formation Antigens - immunology Antigens, Protozoan - immunology Biological and medical sciences Epitopes Human protozoal diseases Humans Immunity (Disease) Immunogenicity Immunoglobulin G - analysis Infectious diseases Malaria Malaria - prevention & control Male Males Medical research Medical sciences Parasites Parasitic diseases Peptides Peptides - chemical synthesis Plasmodium falciparum Plasmodium falciparum - immunology Protozoal diseases Tropical medicine Vaccines Vaccines, Synthetic - immunology Vaccines, Synthetic - standards Vector-borne diseases
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