Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5
We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr) 5. An identical 12-bp insertion in the 3' untransl...
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| Veröffentlicht in: | Genomics 1995-08, Vol.28 (3), p.581-584 |
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| container_title | Genomics |
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| creator | FIEDOREK, F. T KAY, E. S |
| description | We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr) 5. An identical 12-bp insertion in the 3' untranslated region of the mouse Ipf1 gene sequence is present in Mus spretus and Mus m. musculus Czech II mice, two feral strains used for meiotic mapping by backcross analysis. The human IPF1 gene homolog would be expected to map to either chromosome 13q12-q14 or 7pter-q21 based on homology of synteny of other loci in this region of mouse Chr 5. Given its genetic map position, the Ipf1 gene may be part of a cassette of homeodomain-containing transcription factors involved in the development of the pancreas and other foregut-derived organs. |
| doi_str_mv | 10.1006/geno.1995.1193 |
| format | Article |
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T ; KAY, E. S</creator><creatorcontrib>FIEDOREK, F. T ; KAY, E. S</creatorcontrib><description>We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr) 5. An identical 12-bp insertion in the 3' untranslated region of the mouse Ipf1 gene sequence is present in Mus spretus and Mus m. musculus Czech II mice, two feral strains used for meiotic mapping by backcross analysis. The human IPF1 gene homolog would be expected to map to either chromosome 13q12-q14 or 7pter-q21 based on homology of synteny of other loci in this region of mouse Chr 5. 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Biological and molecular evolution ; Genotype ; Homeodomain Proteins ; HUMAN CHROMOSOME 13 ; HUMAN CHROMOSOME 7 ; Humans ; INSULIN ; MICE ; Molecular Sequence Data ; OLIGONUCLEOTIDES ; ONTOGENESIS ; PANCREAS ; POLYMERASE CHAIN REACTION ; Sequence Homology, Amino Acid ; Trans-Activators - genetics ; TRANSCRIPTION FACTORS ; Vertebrata</subject><ispartof>Genomics, 1995-08, Vol.28 (3), p.581-584</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3638727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7490099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/390686$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>FIEDOREK, F. T</creatorcontrib><creatorcontrib>KAY, E. S</creatorcontrib><title>Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5</title><title>Genomics</title><addtitle>Genomics</addtitle><description>We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr) 5. An identical 12-bp insertion in the 3' untranslated region of the mouse Ipf1 gene sequence is present in Mus spretus and Mus m. musculus Czech II mice, two feral strains used for meiotic mapping by backcross analysis. The human IPF1 gene homolog would be expected to map to either chromosome 13q12-q14 or 7pter-q21 based on homology of synteny of other loci in this region of mouse Chr 5. Given its genetic map position, the Ipf1 gene may be part of a cassette of homeodomain-containing transcription factors involved in the development of the pancreas and other foregut-derived organs.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Chromosome Mapping</subject><subject>CHROMOSOMES</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Primers</subject><subject>DNA SEQUENCING</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE MUTATIONS</subject><subject>GENES</subject><subject>GENETIC MAPPING</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Homeodomain Proteins</subject><subject>HUMAN CHROMOSOME 13</subject><subject>HUMAN CHROMOSOME 7</subject><subject>Humans</subject><subject>INSULIN</subject><subject>MICE</subject><subject>Molecular Sequence Data</subject><subject>OLIGONUCLEOTIDES</subject><subject>ONTOGENESIS</subject><subject>PANCREAS</subject><subject>POLYMERASE CHAIN REACTION</subject><subject>Sequence Homology, Amino Acid</subject><subject>Trans-Activators - genetics</subject><subject>TRANSCRIPTION FACTORS</subject><subject>Vertebrata</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVav3oQIInrYmjS7-ThK8aNQEUHPS3Y220Z2k3WTPfjvTWnxNAPvw8wzg9AlJXNKCH_YGOfnVKliTqliR2hKiVSZ5Dk_RlMipcxEkbNTdBbCNyFEMbmYoInIVerVFH286b63boN9g-PWYOvC2FqH-8F3PpoBNxqiHzDFaZHBd6u-ofc4elzbEHWLOz8Gg2G7w4PvDC7O0Umj22AuDnWGvp6fPpev2fr9ZbV8XGc-ecZMA2FSkabKDauooSwZVQoaAbBQyZLndU2Z4FSwSjFaEDAAWlRFVfFaCM5m6Ho_14doywA2GtiCd85ALJkiXO6Y2z2TzvkZTYhlZwOYttXOJPFSiEIRIVgCrw7gWHWmLvvBdnr4LQ9_SvnNIdcBdNsM2oEN_xjjTIqFYH9WN3Vp</recordid><startdate>19950810</startdate><enddate>19950810</enddate><creator>FIEDOREK, F. 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S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o193t-ac03890fb4e3b1e13490b9cf7cc2993864dd1376173b93150cecca7b5bb6d7763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Chromosome Mapping</topic><topic>CHROMOSOMES</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA Primers</topic><topic>DNA SEQUENCING</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE MUTATIONS</topic><topic>GENES</topic><topic>GENETIC MAPPING</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Homeodomain Proteins</topic><topic>HUMAN CHROMOSOME 13</topic><topic>HUMAN CHROMOSOME 7</topic><topic>Humans</topic><topic>INSULIN</topic><topic>MICE</topic><topic>Molecular Sequence Data</topic><topic>OLIGONUCLEOTIDES</topic><topic>ONTOGENESIS</topic><topic>PANCREAS</topic><topic>POLYMERASE CHAIN REACTION</topic><topic>Sequence Homology, Amino Acid</topic><topic>Trans-Activators - genetics</topic><topic>TRANSCRIPTION FACTORS</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FIEDOREK, F. T</creatorcontrib><creatorcontrib>KAY, E. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FIEDOREK, F. T</au><au>KAY, E. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1995-08-10</date><risdate>1995</risdate><volume>28</volume><issue>3</issue><spage>581</spage><epage>584</epage><pages>581-584</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr) 5. An identical 12-bp insertion in the 3' untranslated region of the mouse Ipf1 gene sequence is present in Mus spretus and Mus m. musculus Czech II mice, two feral strains used for meiotic mapping by backcross analysis. The human IPF1 gene homolog would be expected to map to either chromosome 13q12-q14 or 7pter-q21 based on homology of synteny of other loci in this region of mouse Chr 5. Given its genetic map position, the Ipf1 gene may be part of a cassette of homeodomain-containing transcription factors involved in the development of the pancreas and other foregut-derived organs.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>7490099</pmid><doi>10.1006/geno.1995.1193</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Genomics, 1995-08, Vol.28 (3), p.581-584 |
| issn | 0888-7543 1089-8646 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Chromosome Mapping CHROMOSOMES Classical genetics, quantitative genetics, hybrids DNA Primers DNA SEQUENCING Fundamental and applied biological sciences. Psychology GENE MUTATIONS GENES GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution Genotype Homeodomain Proteins HUMAN CHROMOSOME 13 HUMAN CHROMOSOME 7 Humans INSULIN MICE Molecular Sequence Data OLIGONUCLEOTIDES ONTOGENESIS PANCREAS POLYMERASE CHAIN REACTION Sequence Homology, Amino Acid Trans-Activators - genetics TRANSCRIPTION FACTORS Vertebrata |
| title | Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5 |
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