Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment
The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day afte...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1995/03/15, Vol.18(3), pp.416-420 |
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| creator | KIMURA, Yasuhiro KIHIRA, Kenji MIYAKE, Katsushi KITAURA, Teruaki FUKUCHI, Hiroshi |
| description | The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I] CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release. |
| doi_str_mv | 10.1248/bpb.18.416 |
| format | Article |
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The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I] CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.18.416</identifier><identifier>PMID: 7550094</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>6-hydroxydopamine (6-OHDA) ; [125I] CCK8-specific binding ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; CCK8/DA co-existing neuron ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; cholecystokinin octapeptide (CCK8) ; dopamine (DA) ; Frontal Lobe - drug effects ; Frontal Lobe - metabolism ; Iodine Radioisotopes ; Kinetics ; Male ; Medical sciences ; Membrane Proteins - metabolism ; Membrane Proteins - pharmacology ; Membranes - drug effects ; Membranes - metabolism ; Miscellaneous ; Nerve Endings - metabolism ; Neuropharmacology ; Oxidopamine - pharmacology ; Pharmacology. Drug treatments ; Radioligand Assay ; Rats ; Rats, Wistar ; Sensitivity and Specificity ; Sincalide - immunology ; Sincalide - metabolism</subject><ispartof>Biological and Pharmaceutical Bulletin, 1995/03/15, Vol.18(3), pp.416-420</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3574839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7550094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMURA, Yasuhiro</creatorcontrib><creatorcontrib>KIHIRA, Kenji</creatorcontrib><creatorcontrib>MIYAKE, Katsushi</creatorcontrib><creatorcontrib>KITAURA, Teruaki</creatorcontrib><creatorcontrib>FUKUCHI, Hiroshi</creatorcontrib><title>Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I] CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. Particularly in the nucleus accumbens, the delayed recovery of specific binding suggests the loss of the pre-synaptic binding site, which exists in the CCK8/DA co-existing neuron, together with a change in CCK8 release.</description><subject>6-hydroxydopamine (6-OHDA)</subject><subject>[125I] CCK8-specific binding</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>CCK8/DA co-existing neuron</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>cholecystokinin octapeptide (CCK8)</subject><subject>dopamine (DA)</subject><subject>Frontal Lobe - drug effects</subject><subject>Frontal Lobe - metabolism</subject><subject>Iodine Radioisotopes</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - metabolism</subject><subject>Membrane Proteins - pharmacology</subject><subject>Membranes - drug effects</subject><subject>Membranes - metabolism</subject><subject>Miscellaneous</subject><subject>Nerve Endings - metabolism</subject><subject>Neuropharmacology</subject><subject>Oxidopamine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sensitivity and Specificity</subject><subject>Sincalide - immunology</subject><subject>Sincalide - metabolism</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EKkNhwx7JC8QCKYMdx39LOqK0UlGlUlYIRY59M7gkcWp7BPMOPDQeTTRbNvbiO77flQ9CrylZ07pRH7q5W1O1bqh4glaUNbLiNeVP0YpoqipBuXqOXqT0QAiRpGZn6ExyTohuVujvHWx9mMyANz9NNDZD9Cl7m3Do8Xda8-sfJQkD2H3K4Zef_IRvbTYzzNk7wF9nsL73Fl_4yflpi3PAdybji2gK-QXGLpoJEr4MwxB-HwBRXe1dDH_2Lsxm9BPg-wgmjzDll-hZb4YEr5b7HH27_HS_uapubj9fbz7eVJaLJleCO0OldUTKvueO8tqB5lI5KjuArgarpeqUZIRZYzg0klsmqWCMOAGdYOfo3XHuHMPjDlJuR58sDENZNexSKyVXmpfn_wOp0KIWkhbw_RG0MaQUoW_n6EcT9y0l7cFRWxy1VLXFUYHfLFN33QjuhC5SSv52yU2yZujLD1qfThjjslFMF2xzxB5SNls45SYWfwMcGqnW7NC6HKX8lNqiu4WJ_QNEhrL2</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>KIMURA, Yasuhiro</creator><creator>KIHIRA, Kenji</creator><creator>MIYAKE, Katsushi</creator><creator>KITAURA, Teruaki</creator><creator>FUKUCHI, Hiroshi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment</title><author>KIMURA, Yasuhiro ; KIHIRA, Kenji ; MIYAKE, Katsushi ; KITAURA, Teruaki ; FUKUCHI, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-65da17cd077ff5d152de9578d17beeb2ec978b87303caa5e475c3716330d6eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>6-hydroxydopamine (6-OHDA)</topic><topic>[125I] CCK8-specific binding</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>CCK8/DA co-existing neuron</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>cholecystokinin octapeptide (CCK8)</topic><topic>dopamine (DA)</topic><topic>Frontal Lobe - drug effects</topic><topic>Frontal Lobe - metabolism</topic><topic>Iodine Radioisotopes</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - metabolism</topic><topic>Membrane Proteins - pharmacology</topic><topic>Membranes - drug effects</topic><topic>Membranes - metabolism</topic><topic>Miscellaneous</topic><topic>Nerve Endings - metabolism</topic><topic>Neuropharmacology</topic><topic>Oxidopamine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sensitivity and Specificity</topic><topic>Sincalide - immunology</topic><topic>Sincalide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMURA, Yasuhiro</creatorcontrib><creatorcontrib>KIHIRA, Kenji</creatorcontrib><creatorcontrib>MIYAKE, Katsushi</creatorcontrib><creatorcontrib>KITAURA, Teruaki</creatorcontrib><creatorcontrib>FUKUCHI, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMURA, Yasuhiro</au><au>KIHIRA, Kenji</au><au>MIYAKE, Katsushi</au><au>KITAURA, Teruaki</au><au>FUKUCHI, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1995</date><risdate>1995</risdate><volume>18</volume><issue>3</issue><spage>416</spage><epage>420</epage><pages>416-420</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The relative changes in the amount of specific [125I] cholecystokinin octapeptide (CCK8) bound to regional brain membrane preparations after 6-hydroxydopamine (6-OHDA) treatment were examined. The specific binding in the frontal cortex and striatum decreased and reached a minimum on the 3rd day after 6-OHDA treatment. Thereafter, the specific binding recovered to 60% and 65% of control values in the frontal cortex and striatum respectively on the 28th day. On the other hand, in the nucleus accumbens, where CCK8 co-exists in the dopamine neuron, the specific binding decreased gradually, and its recovery was delayed compared with that of the frontal cortex and striatum. In the hippocampus, 6-OHDA treatment had no effect on the specific binding throughout the experimental period. The decrease of [125I] CCK8-specific binding could be caused by enhanced release of CCK8 in the frontal cortex, striatum, and nucleus accumbens, and the recovery of specific binding could be induced by depletion of CCK8 in nerve terminals. 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| ispartof | Biological and Pharmaceutical Bulletin, 1995/03/15, Vol.18(3), pp.416-420 |
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| subjects | 6-hydroxydopamine (6-OHDA) [125I] CCK8-specific binding Animals Biological and medical sciences Brain - drug effects Brain - metabolism CCK8/DA co-existing neuron Cerebral Cortex - drug effects Cerebral Cortex - metabolism cholecystokinin octapeptide (CCK8) dopamine (DA) Frontal Lobe - drug effects Frontal Lobe - metabolism Iodine Radioisotopes Kinetics Male Medical sciences Membrane Proteins - metabolism Membrane Proteins - pharmacology Membranes - drug effects Membranes - metabolism Miscellaneous Nerve Endings - metabolism Neuropharmacology Oxidopamine - pharmacology Pharmacology. Drug treatments Radioligand Assay Rats Rats, Wistar Sensitivity and Specificity Sincalide - immunology Sincalide - metabolism |
| title | Regional Characteristics of [125I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment |
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