Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation (∗)

Insulin and epidermal growth factor receptors transmit signals for cell proliferation and gene regulation through formation of active GTP-bound p21ras mediated by the guanine nucleotide exchange factor Sos. Sos is constitutively bound to the adaptor protein Grb2 and growth factor stimulation induces...

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Veröffentlicht in:	The Journal of biological chemistry 1995-10, Vol.270 (43), p.25320-25323
Hauptverfasser:	Langlois, W. John, Sasaoka, Toshiyasu, Saltiel, Alan R., Olefsky, Jerrold M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Blotting, Western Calcium-Calmodulin-Dependent Protein Kinases - metabolism Down-Regulation Epidermal Growth Factor - pharmacology GRB2 Adaptor Protein Guanine Nucleotide Exchange Factors Guanosine Diphosphate - analysis Guanosine Triphosphate - analysis Humans Insulin - pharmacology Precipitin Tests Proteins - metabolism Proto-Oncogene Proteins p21(ras) - chemistry Proto-Oncogene Proteins p21(ras) - metabolism ras Guanine Nucleotide Exchange Factors Rats Signal Transduction
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