Long-term effects of human-to-rat mesencephalic xenografts on rotational behavior, striatal dopamine receptor binding, and mRNA levels

Fetal ventral mesencephalic grafts have been used as a tool to counteract the symptoms of Parkinson's disease. In this study human fetal ventral mesencephalic xenografts were implanted into the lateral ventricle of unilaterally dopamine-deplated immunosuppressed rats. Rotational behavior elicit...

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Veröffentlicht in:	Brain research bulletin 1995, Vol.38 (3), p.221-233
Hauptverfasser:	Strömberg, Ingrid, Adams, Cathy, Bygdeman, Marc, Hoffer, Barry, Boyson, Sally, Humpel, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Behavioral psychophysiology Binding, Competitive Biological and medical sciences Corpus Striatum - metabolism Dopamine - metabolism Dopamine receptors Female Fundamental and applied biological sciences. Psychology Human xenograft Humans Mesencephalon - transplantation Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis Rotation Rotational behavior Striatum Time Factors Transplant
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