Regulation of the interferon system and cell growth by the IRF transcription factors
Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1995-09, Vol.121 (9-10), p.516-520 |
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| container_issue | 9-10 |
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| container_title | Journal of cancer research and clinical oncology |
| container_volume | 121 |
| creator | TANIGUCHI, T HARADA, H LAMPHIER, M |
| description | Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of transcriptional induction of the IFN genes by viruses, we have discovered two structurally related transcription factors, Interferon regulatory factor 1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell growth and apoptosis. Thus, these studies uncover a complex gene transcription network in which the fate of cellular responses is determined by how the IRF transcription factors function in conjunction with other factors on the promoters of distinct genes under different conditions of the cells. |
| doi_str_mv | 10.1007/BF01197763 |
| format | Article |
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Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of transcriptional induction of the IFN genes by viruses, we have discovered two structurally related transcription factors, Interferon regulatory factor 1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell growth and apoptosis. 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Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Interferon Regulatory Factor-1 ; Interferon Regulatory Factor-2 ; Interferons - physiology ; Lymphokines, interleukins ( function, expression) ; Mice ; Myelodysplastic Syndromes - physiopathology ; Oncogenes ; Phosphoproteins - physiology ; Regulatory factors and their cellular receptors ; Repressor Proteins ; Transcription Factors - physiology</subject><ispartof>Journal of cancer research and clinical oncology, 1995-09, Vol.121 (9-10), p.516-520</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-fccb883693fa7669530b8a53526caab1419a870a142906ea5f39ee7c4f0db2363</citedby><cites>FETCH-LOGICAL-c311t-fccb883693fa7669530b8a53526caab1419a870a142906ea5f39ee7c4f0db2363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3683633$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7559730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANIGUCHI, T</creatorcontrib><creatorcontrib>HARADA, H</creatorcontrib><creatorcontrib>LAMPHIER, M</creatorcontrib><title>Regulation of the interferon system and cell growth by the IRF transcription factors</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of transcriptional induction of the IFN genes by viruses, we have discovered two structurally related transcription factors, Interferon regulatory factor 1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell growth and apoptosis. Thus, these studies uncover a complex gene transcription network in which the fate of cellular responses is determined by how the IRF transcription factors function in conjunction with other factors on the promoters of distinct genes under different conditions of the cells.</description><subject>3T3 Cells</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell Transformation, Neoplastic</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Fundamental and applied biological sciences. 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Humoral and cellular immunity</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cell Transformation, Neoplastic</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interferon Regulatory Factor-1</topic><topic>Interferon Regulatory Factor-2</topic><topic>Interferons - physiology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Mice</topic><topic>Myelodysplastic Syndromes - physiopathology</topic><topic>Oncogenes</topic><topic>Phosphoproteins - physiology</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Repressor Proteins</topic><topic>Transcription Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANIGUCHI, T</creatorcontrib><creatorcontrib>HARADA, H</creatorcontrib><creatorcontrib>LAMPHIER, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANIGUCHI, T</au><au>HARADA, H</au><au>LAMPHIER, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of the interferon system and cell growth by the IRF transcription factors</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>121</volume><issue>9-10</issue><spage>516</spage><epage>520</epage><pages>516-520</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of transcriptional induction of the IFN genes by viruses, we have discovered two structurally related transcription factors, Interferon regulatory factor 1 (IRF-1) and IRF-2. These two factors, however, function not only as regulators of the IFN system, but are also key transcription factors in the regulation of cell growth and apoptosis. Thus, these studies uncover a complex gene transcription network in which the fate of cellular responses is determined by how the IRF transcription factors function in conjunction with other factors on the promoters of distinct genes under different conditions of the cells.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7559730</pmid><doi>10.1007/BF01197763</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 1995-09, Vol.121 (9-10), p.516-520 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 3T3 Cells Analysis of the immune response. Humoral and cellular immunity Animals Apoptosis Biological and medical sciences Cell Division Cell Transformation, Neoplastic DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interferon Regulatory Factor-1 Interferon Regulatory Factor-2 Interferons - physiology Lymphokines, interleukins ( function, expression) Mice Myelodysplastic Syndromes - physiopathology Oncogenes Phosphoproteins - physiology Regulatory factors and their cellular receptors Repressor Proteins Transcription Factors - physiology |
| title | Regulation of the interferon system and cell growth by the IRF transcription factors |
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