N-Methyladrenaline: age-dependent urinary excretion, perinatal organ content and relation with ‘classical’ catecholamines
Using high performance liquid chromatography with electrochemical detection we determined free dopamine, noradrenaline, adrenaline and N-methyladrenaline in: (1) urines from newborns ( n = 32), children ( n = 45) and adults ( n = 19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal...
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| Veröffentlicht in: | Clinica chimica acta 1995-07, Vol.238 (2), p.137-150 |
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| container_title | Clinica chimica acta |
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| creator | Kema, Ido P. Schoots, Coen J.F. Gidding, Corrie E.M. Okken, Albert Aarnoudse, Jan G. Muskiet, Frits A.J. |
| description | Using high performance liquid chromatography with electrochemical detection we determined free dopamine, noradrenaline, adrenaline and
N-methyladrenaline in: (1) urines from newborns (
n = 32), children (
n = 45) and adults (
n = 19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal brown adipose tissue from deceased fetuses (
n = 2), very premature (
n = 6) and term (
n = 2) newborns and infants (
n = 2). Data from children and adults showed that contributions of adrenaline and
N-methyladrenaline to the sum of urinary free catecholamines increase with age. Relative amounts of adrenaline and
N-methyladrenaline increased in both adrenal and extra adrenal chromaffin tissues from late gestation up to several months of postnatal life. Increase of adrenal
N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-
N-methyltransferase induction and subsequent adrenaline synthesis. Relative amounts of
N-methyladrenaline in extra adrenal chromaffin tissue increase in a period that is associated with its regression. Further investigations are necessary to elucidate the function and possible clinical chemical usefulness of
N-methyladrenaline. |
| doi_str_mv | 10.1016/0009-8981(95)06082-O |
| format | Article |
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N-methyladrenaline in: (1) urines from newborns (
n = 32), children (
n = 45) and adults (
n = 19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal brown adipose tissue from deceased fetuses (
n = 2), very premature (
n = 6) and term (
n = 2) newborns and infants (
n = 2). Data from children and adults showed that contributions of adrenaline and
N-methyladrenaline to the sum of urinary free catecholamines increase with age. Relative amounts of adrenaline and
N-methyladrenaline increased in both adrenal and extra adrenal chromaffin tissues from late gestation up to several months of postnatal life. Increase of adrenal
N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-
N-methyltransferase induction and subsequent adrenaline synthesis. Relative amounts of
N-methyladrenaline in extra adrenal chromaffin tissue increase in a period that is associated with its regression. Further investigations are necessary to elucidate the function and possible clinical chemical usefulness of
N-methyladrenaline.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(95)06082-O</identifier><identifier>PMID: 7586573</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adrenal Glands - metabolism ; Adrenaline ; Adult ; Aging - metabolism ; Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Catecholamines - metabolism ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Electrochemistry ; Epinephrine - analogs & derivatives ; Epinephrine - metabolism ; Epinephrine - urine ; Extra adrenal chromaffin tissue ; Female ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; Gestational Age ; High performance liquid chromatography ; Humans ; Indicators and Reagents ; Infant ; Infant, Newborn ; Infant, Premature ; Male ; Middle Aged ; Phenylethanolamine- N-methyltransferase ; Proteins</subject><ispartof>Clinica chimica acta, 1995-07, Vol.238 (2), p.137-150</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5ebc496ab3c63c839d161fb87770e925be2677511d8756a1f64cc8c5e59a56143</citedby><cites>FETCH-LOGICAL-c386t-5ebc496ab3c63c839d161fb87770e925be2677511d8756a1f64cc8c5e59a56143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(95)06082-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3617467$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7586573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kema, Ido P.</creatorcontrib><creatorcontrib>Schoots, Coen J.F.</creatorcontrib><creatorcontrib>Gidding, Corrie E.M.</creatorcontrib><creatorcontrib>Okken, Albert</creatorcontrib><creatorcontrib>Aarnoudse, Jan G.</creatorcontrib><creatorcontrib>Muskiet, Frits A.J.</creatorcontrib><title>N-Methyladrenaline: age-dependent urinary excretion, perinatal organ content and relation with ‘classical’ catecholamines</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Using high performance liquid chromatography with electrochemical detection we determined free dopamine, noradrenaline, adrenaline and
N-methyladrenaline in: (1) urines from newborns (
n = 32), children (
n = 45) and adults (
n = 19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal brown adipose tissue from deceased fetuses (
n = 2), very premature (
n = 6) and term (
n = 2) newborns and infants (
n = 2). Data from children and adults showed that contributions of adrenaline and
N-methyladrenaline to the sum of urinary free catecholamines increase with age. Relative amounts of adrenaline and
N-methyladrenaline increased in both adrenal and extra adrenal chromaffin tissues from late gestation up to several months of postnatal life. Increase of adrenal
N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-
N-methyltransferase induction and subsequent adrenaline synthesis. Relative amounts of
N-methyladrenaline in extra adrenal chromaffin tissue increase in a period that is associated with its regression. Further investigations are necessary to elucidate the function and possible clinical chemical usefulness of
N-methyladrenaline.</description><subject>Adrenal Glands - metabolism</subject><subject>Adrenaline</subject><subject>Adult</subject><subject>Aging - metabolism</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Electrochemistry</subject><subject>Epinephrine - analogs & derivatives</subject><subject>Epinephrine - metabolism</subject><subject>Epinephrine - urine</subject><subject>Extra adrenal chromaffin tissue</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Gestational Age</subject><subject>High performance liquid chromatography</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenylethanolamine- N-methyltransferase</subject><subject>Proteins</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAQxy0EKkvhDUDyAaEiEbCT-CMcKlUVX1JhL3C2nMmka-R1tra30ANSHwNer0-Cw672yMkaz-8_9vwIecrZa864fMMY6yrdaX7SiZdMMl1Xy3tkwbVqqqbt6vtkcUAekkcpfS9lyyQ_IkdKaClUsyC_vlSfMa9uvB0iButdwLfUXmI14AbDgCHTbXTBxhuKPyFidlN4RTc432Xr6RQvbaAwhTyjNgw0orczRX-4vKJ3t7_B25QcWH93-4eCzQirydt1eSk9Jg9G6xM-2Z_H5Nv7d1_PP1YXyw-fzs8uKmi0zJXAHtpO2r4B2YBuuoFLPvZaKcWwq0WPtVRKcD5oJaTlo2wBNAgUnRWSt80xebGbu4nT1RZTNmuXAL23AadtMiWsa1nrArY7EOKUUsTRbKJbl-0NZ2a2bmalZlZqOmH-WTfLEnu2n7_t1zgcQnvNpf9837epiBijDeDSAWskV61UBTvdYVhcXDuMJoHDADi4iJDNMLn__-MvJgyiDQ</recordid><startdate>19950714</startdate><enddate>19950714</enddate><creator>Kema, Ido P.</creator><creator>Schoots, Coen J.F.</creator><creator>Gidding, Corrie E.M.</creator><creator>Okken, Albert</creator><creator>Aarnoudse, Jan G.</creator><creator>Muskiet, Frits A.J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950714</creationdate><title>N-Methyladrenaline: age-dependent urinary excretion, perinatal organ content and relation with ‘classical’ catecholamines</title><author>Kema, Ido P. ; Schoots, Coen J.F. ; Gidding, Corrie E.M. ; Okken, Albert ; Aarnoudse, Jan G. ; Muskiet, Frits A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5ebc496ab3c63c839d161fb87770e925be2677511d8756a1f64cc8c5e59a56143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adrenal Glands - metabolism</topic><topic>Adrenaline</topic><topic>Adult</topic><topic>Aging - metabolism</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Catecholamines - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Electrochemistry</topic><topic>Epinephrine - analogs & derivatives</topic><topic>Epinephrine - metabolism</topic><topic>Epinephrine - urine</topic><topic>Extra adrenal chromaffin tissue</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Gestational Age</topic><topic>High performance liquid chromatography</topic><topic>Humans</topic><topic>Indicators and Reagents</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phenylethanolamine- N-methyltransferase</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kema, Ido P.</creatorcontrib><creatorcontrib>Schoots, Coen J.F.</creatorcontrib><creatorcontrib>Gidding, Corrie E.M.</creatorcontrib><creatorcontrib>Okken, Albert</creatorcontrib><creatorcontrib>Aarnoudse, Jan G.</creatorcontrib><creatorcontrib>Muskiet, Frits A.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kema, Ido P.</au><au>Schoots, Coen J.F.</au><au>Gidding, Corrie E.M.</au><au>Okken, Albert</au><au>Aarnoudse, Jan G.</au><au>Muskiet, Frits A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Methyladrenaline: age-dependent urinary excretion, perinatal organ content and relation with ‘classical’ catecholamines</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1995-07-14</date><risdate>1995</risdate><volume>238</volume><issue>2</issue><spage>137</spage><epage>150</epage><pages>137-150</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>Using high performance liquid chromatography with electrochemical detection we determined free dopamine, noradrenaline, adrenaline and
N-methyladrenaline in: (1) urines from newborns (
n = 32), children (
n = 45) and adults (
n = 19) and (2) adrenals, organ of Zuckerkandl, dorsal roots and perirenal brown adipose tissue from deceased fetuses (
n = 2), very premature (
n = 6) and term (
n = 2) newborns and infants (
n = 2). Data from children and adults showed that contributions of adrenaline and
N-methyladrenaline to the sum of urinary free catecholamines increase with age. Relative amounts of adrenaline and
N-methyladrenaline increased in both adrenal and extra adrenal chromaffin tissues from late gestation up to several months of postnatal life. Increase of adrenal
N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-
N-methyltransferase induction and subsequent adrenaline synthesis. Relative amounts of
N-methyladrenaline in extra adrenal chromaffin tissue increase in a period that is associated with its regression. Further investigations are necessary to elucidate the function and possible clinical chemical usefulness of
N-methyladrenaline.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>7586573</pmid><doi>10.1016/0009-8981(95)06082-O</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinica chimica acta, 1995-07, Vol.238 (2), p.137-150 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77582628 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenal Glands - metabolism Adrenaline Adult Aging - metabolism Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Catecholamines - metabolism Child Child, Preschool Chromatography, High Pressure Liquid Electrochemistry Epinephrine - analogs & derivatives Epinephrine - metabolism Epinephrine - urine Extra adrenal chromaffin tissue Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Gestational Age High performance liquid chromatography Humans Indicators and Reagents Infant Infant, Newborn Infant, Premature Male Middle Aged Phenylethanolamine- N-methyltransferase Proteins |
| title | N-Methyladrenaline: age-dependent urinary excretion, perinatal organ content and relation with ‘classical’ catecholamines |
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