Formation of lipoxin A by granulocytes from eosinophilic donors

The formation of arachidonic acid-derived lipoxygenase products was examined with human granulocytes obtained from eosinophilic donors. These eosinophil-enriched leukocyte populations, challenged in vitro with the ionophore of divalent cations A23187, transformed both exogenous and endogenous source...

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Veröffentlicht in:	FEBS letters 1987-06, Vol.217 (2), p.242-246
Hauptverfasser:	Serhan, Charles N., Hirsch, Ulf, Palmblad, Jan, Samuelsson, Bengt
Format:	Artikel
Sprache:	eng
Schlagworte:	15 -HETE, 15(S)-hydroxy-5,8,11-cis-13-trans -eicosatetraenoic acid 5,15 -DHETE, 5(S),15(S)-dihydroxy-6,13-trans-8,11-cis -eicosatetraenoic acid 6(S)-LXA, 5(S),6(S),15(S)-trihydroxy-7,9,13-trans-11 -cis-eicosatetraenoic acid Analytical, structural and metabolic biochemistry Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Calcimycin - pharmacology Eosinophil Eosinophilia - pathology Fundamental and applied biological sciences. Psychology GC, gas-liquid chromatography Granulocytes - drug effects Granulocytes - metabolism Granulocytes - pathology HES, hypereosinophilic syndrome Human Humans Hydroxyeicosatetraenoic Acids - biosynthesis Leukocyte Lipids lipoxin A (LXA), 5(S),6(R),15(S) -trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid lipoxin B (LXB), 5(S),14(R),15(S) -trihydroxy-6,10,12-trans-8-cis-eicosatetraenoic acid Lipoxins Lipoxygenase product LX, lipoxin Me3Si, trimethylsilyl MS, mass spectrometry Other biological molecules RP-HPLC, reverse-phase high-pressure liquid chromatography SRS-A - biosynthesis
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