Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging
The purpose of this study was to investigate the feasibility of first-pass MR imaging for measurement of regional myocardial blood flow in human beings. The first pass of the contrast agent Gd-DTPA through the myocardium was imaged in 12 normal volunteers with an EGG-gated Turbo-Flash sequence. The...
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| Veröffentlicht in: | The American heart journal 1995-10, Vol.130 (4), p.893-901 |
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| container_title | The American heart journal |
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| creator | Keijer, Jan T. van Rossum, Albert C. van Eenige, Machiel J. Karreman, Arend J.P. Hofman, Mark B.M. Valk, Jaap Visser, Cees A. |
| description | The purpose of this study was to investigate the feasibility of first-pass MR imaging for measurement of regional myocardial blood flow in human beings. The first pass of the contrast agent Gd-DTPA through the myocardium was imaged in 12 normal volunteers with an EGG-gated Turbo-Flash sequence. The MTT of the contrast agent through the myocardium after a bolus injection was derived from curves of SI versus time. The bolus was injected through an intravenous catheter, which was advanced to the central venous position (preferably the right atrium). To investigate myocardial input function, different bolus concentrations and catheter positions were compared. It is concluded that first-pass MR imaging is feasible in human subjects when a central injection of 0.03 mmol/kg of Gd-DTPA is applied. MTT values were similar throughout the myocardium of normal subjects at rest, reflecting normal perfusion. Absolute values of MTT were related to the myocardial input. |
| doi_str_mv | 10.1016/0002-8703(95)90092-6 |
| format | Article |
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The first pass of the contrast agent Gd-DTPA through the myocardium was imaged in 12 normal volunteers with an EGG-gated Turbo-Flash sequence. The MTT of the contrast agent through the myocardium after a bolus injection was derived from curves of SI versus time. The bolus was injected through an intravenous catheter, which was advanced to the central venous position (preferably the right atrium). To investigate myocardial input function, different bolus concentrations and catheter positions were compared. It is concluded that first-pass MR imaging is feasible in human subjects when a central injection of 0.03 mmol/kg of Gd-DTPA is applied. MTT values were similar throughout the myocardium of normal subjects at rest, reflecting normal perfusion. Absolute values of MTT were related to the myocardial input.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(95)90092-6</identifier><identifier>PMID: 7572601</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Cardiovascular system ; Contrast Media ; Coronary Circulation ; Coronary Vessels - pathology ; Feasibility Studies ; Female ; Gadolinium DTPA ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Myocardium - pathology ; Organometallic Compounds ; Pentetic Acid - analogs & derivatives ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Regional Blood Flow</subject><ispartof>The American heart journal, 1995-10, Vol.130 (4), p.893-901</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-b96a513c5c6c40d085fd45f4fc33abf372e2d3a0ad49c36e9c12b0b5eb6986953</citedby><cites>FETCH-LOGICAL-c367t-b96a513c5c6c40d085fd45f4fc33abf372e2d3a0ad49c36e9c12b0b5eb6986953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-8703(95)90092-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3682602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7572601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keijer, Jan T.</creatorcontrib><creatorcontrib>van Rossum, Albert C.</creatorcontrib><creatorcontrib>van Eenige, Machiel J.</creatorcontrib><creatorcontrib>Karreman, Arend J.P.</creatorcontrib><creatorcontrib>Hofman, Mark B.M.</creatorcontrib><creatorcontrib>Valk, Jaap</creatorcontrib><creatorcontrib>Visser, Cees A.</creatorcontrib><title>Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>The purpose of this study was to investigate the feasibility of first-pass MR imaging for measurement of regional myocardial blood flow in human beings. The first pass of the contrast agent Gd-DTPA through the myocardium was imaged in 12 normal volunteers with an EGG-gated Turbo-Flash sequence. The MTT of the contrast agent through the myocardium after a bolus injection was derived from curves of SI versus time. The bolus was injected through an intravenous catheter, which was advanced to the central venous position (preferably the right atrium). To investigate myocardial input function, different bolus concentrations and catheter positions were compared. It is concluded that first-pass MR imaging is feasible in human subjects when a central injection of 0.03 mmol/kg of Gd-DTPA is applied. MTT values were similar throughout the myocardium of normal subjects at rest, reflecting normal perfusion. Absolute values of MTT were related to the myocardial input.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Contrast Media</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels - pathology</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardium - pathology</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Regional Blood Flow</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyENFDr-mkk-5cBFnUFRb2oJ5DPscs3clsknaZf2-NM8zRUypVT70UD0Kve3LVk158JITQbhoJey_5B0mIpJ14gjY9kWMnxmF4ijZn5Dl6Ues9fAWdxAW6GPlIBek3qP3wS3xYdWqx6RZzwjng4rdQ6Rkv-2x1cRFKM-fscJjzI44Jp1wWaP5eF51wXc29t61is8chltq6na4VL3qbfIsW4iqkJetxhF5M25foWdBz9a9O7yX69fXLz-ub7vbu2_frz7edZWJsnZFC855ZboUdiCMTD27gYQiWMW0CG6mnjmmi3SBhw0vbU0MM90bISUjOLtG7Y-6u5IfV16aWWK2fZ518XqsaRz4RKiYAhyNoS661-KB2BW4te9UTdZCtDibVwaSSXP2TrQSsvTnlr2bx7rx0sgvzt6e5rlbPoYCEWM8YExNgFLBPR8yDiz_RF1Vt9ODLxQJelcvx_3f8BaTLnTQ</recordid><startdate>199510</startdate><enddate>199510</enddate><creator>Keijer, Jan T.</creator><creator>van Rossum, Albert C.</creator><creator>van Eenige, Machiel J.</creator><creator>Karreman, Arend J.P.</creator><creator>Hofman, Mark B.M.</creator><creator>Valk, Jaap</creator><creator>Visser, Cees A.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199510</creationdate><title>Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging</title><author>Keijer, Jan T. ; van Rossum, Albert C. ; van Eenige, Machiel J. ; Karreman, Arend J.P. ; Hofman, Mark B.M. ; Valk, Jaap ; Visser, Cees A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-b96a513c5c6c40d085fd45f4fc33abf372e2d3a0ad49c36e9c12b0b5eb6986953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Contrast Media</topic><topic>Coronary Circulation</topic><topic>Coronary Vessels - pathology</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardium - pathology</topic><topic>Organometallic Compounds</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Regional Blood Flow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keijer, Jan T.</creatorcontrib><creatorcontrib>van Rossum, Albert C.</creatorcontrib><creatorcontrib>van Eenige, Machiel J.</creatorcontrib><creatorcontrib>Karreman, Arend J.P.</creatorcontrib><creatorcontrib>Hofman, Mark B.M.</creatorcontrib><creatorcontrib>Valk, Jaap</creatorcontrib><creatorcontrib>Visser, Cees A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keijer, Jan T.</au><au>van Rossum, Albert C.</au><au>van Eenige, Machiel J.</au><au>Karreman, Arend J.P.</au><au>Hofman, Mark B.M.</au><au>Valk, Jaap</au><au>Visser, Cees A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1995-10</date><risdate>1995</risdate><volume>130</volume><issue>4</issue><spage>893</spage><epage>901</epage><pages>893-901</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>The purpose of this study was to investigate the feasibility of first-pass MR imaging for measurement of regional myocardial blood flow in human beings. The first pass of the contrast agent Gd-DTPA through the myocardium was imaged in 12 normal volunteers with an EGG-gated Turbo-Flash sequence. The MTT of the contrast agent through the myocardium after a bolus injection was derived from curves of SI versus time. The bolus was injected through an intravenous catheter, which was advanced to the central venous position (preferably the right atrium). To investigate myocardial input function, different bolus concentrations and catheter positions were compared. It is concluded that first-pass MR imaging is feasible in human subjects when a central injection of 0.03 mmol/kg of Gd-DTPA is applied. MTT values were similar throughout the myocardium of normal subjects at rest, reflecting normal perfusion. Absolute values of MTT were related to the myocardial input.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>7572601</pmid><doi>10.1016/0002-8703(95)90092-6</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cardiovascular system Contrast Media Coronary Circulation Coronary Vessels - pathology Feasibility Studies Female Gadolinium DTPA Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Myocardium - pathology Organometallic Compounds Pentetic Acid - analogs & derivatives Radiodiagnosis. Nmr imagery. Nmr spectrometry Regional Blood Flow |
| title | Semiquantitation of regional myocardial blood flow in normal human subjects by first-pass magnetic resonance imaging |
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