HLA-G deletion polymorphism and pre-eclampsia/eclampsia
To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population. A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups. Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients wer...
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| Veröffentlicht in: | British journal of obstetrics and gynaecology 1995-09, Vol.102 (9), p.707-710 |
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| container_end_page | 710 |
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| container_title | British journal of obstetrics and gynaecology |
| container_volume | 102 |
| creator | HUMPHREY, K. E HARRISON, G. A WILTON, A. N BRENNECKE, S. P TRUDINGER, B. J |
| description | To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.
A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Genotypic and gene frequencies were not significantly different in the seven groups examined.
There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype. |
| format | Article |
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A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Genotypic and gene frequencies were not significantly different in the seven groups examined.
There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.</description><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1365-215X</identifier><identifier>PMID: 7547760</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Eclampsia - genetics ; Female ; Gene Deletion ; Gene Frequency ; Gynecology. Andrology. Obstetrics ; HLA Antigens - genetics ; Humans ; Male ; Medical sciences ; Pedigree ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Pre-Eclampsia - genetics ; Pregnancy ; Pregnancy. Fetus. Placenta</subject><ispartof>British journal of obstetrics and gynaecology, 1995-09, Vol.102 (9), p.707-710</ispartof><rights>1995 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3664272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7547760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUMPHREY, K. E</creatorcontrib><creatorcontrib>HARRISON, G. A</creatorcontrib><creatorcontrib>WILTON, A. N</creatorcontrib><creatorcontrib>BRENNECKE, S. P</creatorcontrib><creatorcontrib>TRUDINGER, B. J</creatorcontrib><title>HLA-G deletion polymorphism and pre-eclampsia/eclampsia</title><title>British journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.
A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Genotypic and gene frequencies were not significantly different in the seven groups examined.
There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.</description><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Eclampsia - genetics</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Gene Frequency</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pedigree</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Pre-Eclampsia - genetics</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><issn>0306-5456</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09Lw0AUxBdRaq1-BCEH8ba4_96-zbEUbQsBLz14C6_JBiObZM22h357A4aeZmB-MzA3bCm1Ba4kfN2ypdDCcjBg79lDSj9CCERrFmyBYCYnlgx3xZpvs9oHf2qHPotDuHTDGL_b1GXU11kcPfdVoC6mlt6u7pHdNRSSf5p1xQ4f74fNjhef2_1mXfDolOCNkY11aLFS-qik1zmArrUjqcFhYwA82Dw3QKQJcyk0Omp8LpyTpFSuV-z1fzaOw-_Zp1PZtanyIVDvh3MqEWGqaZzA5xk8Hztfl3FsOxov5Xx0yl_mnFJFoRmpr9p0xbS1RqHSf3DWWkg</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>HUMPHREY, K. E</creator><creator>HARRISON, G. A</creator><creator>WILTON, A. N</creator><creator>BRENNECKE, S. P</creator><creator>TRUDINGER, B. J</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199509</creationdate><title>HLA-G deletion polymorphism and pre-eclampsia/eclampsia</title><author>HUMPHREY, K. E ; HARRISON, G. A ; WILTON, A. N ; BRENNECKE, S. P ; TRUDINGER, B. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p820-f41f68767c23b21e39553d38a13587f455e569945aa3a7910378afe90881a2293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Eclampsia - genetics</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Gene Frequency</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pedigree</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Pre-Eclampsia - genetics</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>online_resources</toplevel><creatorcontrib>HUMPHREY, K. E</creatorcontrib><creatorcontrib>HARRISON, G. A</creatorcontrib><creatorcontrib>WILTON, A. N</creatorcontrib><creatorcontrib>BRENNECKE, S. P</creatorcontrib><creatorcontrib>TRUDINGER, B. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUMPHREY, K. E</au><au>HARRISON, G. A</au><au>WILTON, A. N</au><au>BRENNECKE, S. P</au><au>TRUDINGER, B. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-G deletion polymorphism and pre-eclampsia/eclampsia</atitle><jtitle>British journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1995-09</date><risdate>1995</risdate><volume>102</volume><issue>9</issue><spage>707</spage><epage>710</epage><pages>707-710</pages><issn>0306-5456</issn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.
A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Genotypic and gene frequencies were not significantly different in the seven groups examined.
There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>7547760</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0306-5456 |
| ispartof | British journal of obstetrics and gynaecology, 1995-09, Vol.102 (9), p.707-710 |
| issn | 0306-5456 1365-215X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Diseases of mother, fetus and pregnancy Eclampsia - genetics Female Gene Deletion Gene Frequency Gynecology. Andrology. Obstetrics HLA Antigens - genetics Humans Male Medical sciences Pedigree Polymerase Chain Reaction Polymorphism, Genetic Pre-Eclampsia - genetics Pregnancy Pregnancy. Fetus. Placenta |
| title | HLA-G deletion polymorphism and pre-eclampsia/eclampsia |
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