NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species : implication for cell death

The ability of glutamate to stimulate generation of intracellular oxidant species was determined by microfluorescence in cerebellar granule cells loaded with the oxidant-sensitive fluorescent dye 2,7-dichlorofluorescin (DCF). Exposure of cells to glutamate (10 microM) produced a rapid generation of...

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Veröffentlicht in:	Journal of neurochemistry 1995-11, Vol.65 (5), p.2016-2021
Hauptverfasser:	GUNASEKAR, P. G, KANTHASAMY, A. G, BOROWITZ, J. L, ISOM, G. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - physiology Cell Death - physiology Cells, Cultured Cerebellum - cytology Cerebellum - drug effects Cerebellum - metabolism Development. Senescence. Regeneration. Transplantation Extracellular Space - metabolism Fluoresceins - metabolism Fundamental and applied biological sciences. Psychology Glutamic Acid - pharmacology L-Lactate Dehydrogenase - metabolism Neuroprotective Agents - pharmacology Nitric Oxide - biosynthesis Oxidation-Reduction Protein Kinase C - physiology Quinacrine - pharmacology Rats Reactive Oxygen Species - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Vertebrates: nervous system and sense organs
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