Effects of intraoperative N-acetylcysteine in orthotopic liver transplantation
N-acetylcysteine (NAC) is an antioxidant agent which has been shown to benefit patients with fulminant hepatic failure. We have examined its effect in patients with chronic liver disease undergoing orthotopic liver transplantation by giving NAC during operation. In a prospective, randomized, double-...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1995-09, Vol.75 (3), p.352-354 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Bromley, P N Cottam, S J Hilmi, I Tan, K C Heaton, N Ginsburg, R Potter, D R |
| description | N-acetylcysteine (NAC) is an antioxidant agent which has been shown to benefit patients with fulminant hepatic failure. We have examined its effect in patients with chronic liver disease undergoing orthotopic liver transplantation by giving NAC during operation. In a prospective, randomized, double-blind, placebo-controlled study of 50 patients, NAC appeared to induce mild vasodilatation, improve oxygen delivery and consumption, and reduce base deficit, but data interpretation was difficult. There were no significant effects on mortality, morbidity or postoperative graft function. |
| doi_str_mv | 10.1093/bja/75.3.352 |
| format | Article |
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We have examined its effect in patients with chronic liver disease undergoing orthotopic liver transplantation by giving NAC during operation. In a prospective, randomized, double-blind, placebo-controlled study of 50 patients, NAC appeared to induce mild vasodilatation, improve oxygen delivery and consumption, and reduce base deficit, but data interpretation was difficult. There were no significant effects on mortality, morbidity or postoperative graft function.</description><subject>Acetylcysteine - therapeutic use</subject><subject>Adult</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Double-Blind Method</subject><subject>Free Radical Scavengers - therapeutic use</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Graft Rejection - prevention & control</subject><subject>Humans</subject><subject>Intraoperative Care</subject><subject>Liver Transplantation</subject><subject>Medical sciences</subject><subject>Oxygen Consumption</subject><subject>Pharmacology. 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Vitamins</topic><topic>Graft Rejection - prevention & control</topic><topic>Humans</topic><topic>Intraoperative Care</topic><topic>Liver Transplantation</topic><topic>Medical sciences</topic><topic>Oxygen Consumption</topic><topic>Pharmacology. 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| ispartof | British journal of anaesthesia : BJA, 1995-09, Vol.75 (3), p.352-354 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetylcysteine - therapeutic use Adult Antioxidants - therapeutic use Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Double-Blind Method Free Radical Scavengers - therapeutic use General and cellular metabolism. Vitamins Graft Rejection - prevention & control Humans Intraoperative Care Liver Transplantation Medical sciences Oxygen Consumption Pharmacology. Drug treatments Prospective Studies Treatment Outcome Vascular Resistance - drug effects |
| title | Effects of intraoperative N-acetylcysteine in orthotopic liver transplantation |
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