Chronic Ursodeoxycholic Acid- and Chenodeoxycholic Acid-Feeding-Induced Changes of Colon Mucosal Cell Proliferation in Rats

Hyperproliferation has been suggested to play a major role in bile acid-dependent colorectal tumor promotion. Effects of chronic feeding of chenodeoxycholic acid (CDC) and ursodeoxycholic acid (UDC) were tested on cell proliferation in the colon of male noninbred Wistar rats. By use of a dynamic met...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1987-07, Vol.79 (1), p.163-166
Hauptverfasser:	Simanowski, Ulrich A., Seitz, Helmut K., Czygan, Peter, Hörner, Martin, Waldherr, Rüdiger, Weber, Ernst, Kommerell, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division Chenodeoxycholic Acid - administration & dosage Chenodeoxycholic Acid - pharmacology Colon - cytology Colon - drug effects Deoxycholic Acid - analogs & derivatives Drug toxicity and drugs side effects treatment Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Male Medical sciences Mitotic Index Pharmacology. Drug treatments Rats Toxicity: digestive system Ursodeoxycholic Acid - administration & dosage Ursodeoxycholic Acid - pharmacology
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