An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection
Infection with Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association between MHC-DRB1 alleles and faecal egg counts following natural, predominat...
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| Veröffentlicht in: | International journal for parasitology 1995-07, Vol.25 (7), p.815-822 |
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| container_title | International journal for parasitology |
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| creator | Schwaiger, F.-W. Gostomski, D. Stear, M.J. Duncan, J.L. McKellar, Q.A. Epplen, J.T. Buitkamp, J. |
| description | Infection with
Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association between
MHC-DRB1 alleles and faecal egg counts following natural, predominately
O. circumcincta infection in a flock of Scottish Blackface sheep. Nineteen
DRB1 alleles were identified by a combination of variation in the length of simple repetitive sequences within the intron between exons 2 and 3 and hybridisation of selected oligonucleotides to polymorphisms within exon 2. Faecal samples were taken from 200 lambs from one to six months of age at intervals of 4 weeks. Genetic effects were strongest at 6 months of age. Least-squares analysis indicated that substitution of the most common allele (I) by allele G2 would result in a 58-fold reduction in faecal egg counts in 6-month-old lambs and a 22-fold reduction in 5-month-old lambs. These results suggest that the major histocompatibility complex plays an important role in the development of resistance to
O. circumcincta. |
| doi_str_mv | 10.1016/0020-7519(94)00216-B |
| format | Article |
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Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association between
MHC-DRB1 alleles and faecal egg counts following natural, predominately
O. circumcincta infection in a flock of Scottish Blackface sheep. Nineteen
DRB1 alleles were identified by a combination of variation in the length of simple repetitive sequences within the intron between exons 2 and 3 and hybridisation of selected oligonucleotides to polymorphisms within exon 2. Faecal samples were taken from 200 lambs from one to six months of age at intervals of 4 weeks. Genetic effects were strongest at 6 months of age. Least-squares analysis indicated that substitution of the most common allele (I) by allele G2 would result in a 58-fold reduction in faecal egg counts in 6-month-old lambs and a 22-fold reduction in 5-month-old lambs. These results suggest that the major histocompatibility complex plays an important role in the development of resistance to
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Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association between
MHC-DRB1 alleles and faecal egg counts following natural, predominately
O. circumcincta infection in a flock of Scottish Blackface sheep. Nineteen
DRB1 alleles were identified by a combination of variation in the length of simple repetitive sequences within the intron between exons 2 and 3 and hybridisation of selected oligonucleotides to polymorphisms within exon 2. Faecal samples were taken from 200 lambs from one to six months of age at intervals of 4 weeks. Genetic effects were strongest at 6 months of age. Least-squares analysis indicated that substitution of the most common allele (I) by allele G2 would result in a 58-fold reduction in faecal egg counts in 6-month-old lambs and a 22-fold reduction in 5-month-old lambs. These results suggest that the major histocompatibility complex plays an important role in the development of resistance to
O. circumcincta.</description><subject>Alleles</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>disease association</subject><subject>DNA Probes - genetics</subject><subject>DRB-typing</subject><subject>faecal egg count</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>Helminthic diseases</subject><subject>Infectious diseases</subject><subject>Major Histocompatibility Complex</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MHC</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Ostertagia circumcincta</subject><subject>Ostertagiasis - genetics</subject><subject>Ostertagiasis - immunology</subject><subject>Ostertagiasis - veterinary</subject><subject>Parasite Egg Count</subject><subject>Parasitic diseases</subject><subject>Sheep - genetics</subject><subject>Sheep - immunology</subject><subject>Sheep Diseases - genetics</subject><subject>Sheep Diseases - immunology</subject><subject>Sheep Diseases - parasitology</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1qGzEQhZfSkjpp36AFXZTSQrdd7Z9WN4U4_YWUQMm9GGtHzgSt5EjapH6cvGnl2viyV8NwvjMM5xTFK1595BXvP1VVXZWi4_KdbN_nhffl8kmx4IOQZcWb7mmxOCLPi9MYb6uKd03bnhQnouuGrheL4vHcMX9PDtkvuPWB3VBMXvtpA4lWZClt2W6z-Id9-b3kDKxFi4wigxi9Jkg4sgdKN8z6B2YANViG63V2zS5FZrzNArk1c5DmAPYD2wQc_UQOXLJbdhUThgRrAqYp6HnS5HQCRs6gTuTdi-KZARvx5WGeFdffvl5f_Cgvr77_vDi_LHUz9KlswPTtYGTLDfRdbSTUsu75CAK11EO_Mlz3Td3KAVCIYdXWAwDnAkAawUVzVrzdn90EfzdjTGqiqNFacOjnqIToRCtFl8F2D-rgYwxo1CbQBGGreKV2xahd6mqXupKt-leMWmbb68P9eTXheDQdmsj6m4MOMWdoAjhN8Yg1ff615xn7vMcwR3FPGFTUhE7jSCHnpUZP___jLw3irW0</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Schwaiger, F.-W.</creator><creator>Gostomski, D.</creator><creator>Stear, M.J.</creator><creator>Duncan, J.L.</creator><creator>McKellar, Q.A.</creator><creator>Epplen, J.T.</creator><creator>Buitkamp, J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection</title><author>Schwaiger, F.-W. ; Gostomski, D. ; Stear, M.J. ; Duncan, J.L. ; McKellar, Q.A. ; Epplen, J.T. ; Buitkamp, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-3af648f941fa652f9a29261da7ec9c86bf1c632498ae778b428aa117aa9f7173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>disease association</topic><topic>DNA Probes - genetics</topic><topic>DRB-typing</topic><topic>faecal egg count</topic><topic>Feces - parasitology</topic><topic>Female</topic><topic>Helminthic diseases</topic><topic>Infectious diseases</topic><topic>Major Histocompatibility Complex</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MHC</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Ostertagia circumcincta</topic><topic>Ostertagiasis - genetics</topic><topic>Ostertagiasis - immunology</topic><topic>Ostertagiasis - veterinary</topic><topic>Parasite Egg Count</topic><topic>Parasitic diseases</topic><topic>Sheep - genetics</topic><topic>Sheep - immunology</topic><topic>Sheep Diseases - genetics</topic><topic>Sheep Diseases - immunology</topic><topic>Sheep Diseases - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwaiger, F.-W.</creatorcontrib><creatorcontrib>Gostomski, D.</creatorcontrib><creatorcontrib>Stear, M.J.</creatorcontrib><creatorcontrib>Duncan, J.L.</creatorcontrib><creatorcontrib>McKellar, Q.A.</creatorcontrib><creatorcontrib>Epplen, J.T.</creatorcontrib><creatorcontrib>Buitkamp, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwaiger, F.-W.</au><au>Gostomski, D.</au><au>Stear, M.J.</au><au>Duncan, J.L.</au><au>McKellar, Q.A.</au><au>Epplen, J.T.</au><au>Buitkamp, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>25</volume><issue>7</issue><spage>815</spage><epage>822</epage><pages>815-822</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><coden>IJPYBT</coden><abstract>Infection with
Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association between
MHC-DRB1 alleles and faecal egg counts following natural, predominately
O. circumcincta infection in a flock of Scottish Blackface sheep. Nineteen
DRB1 alleles were identified by a combination of variation in the length of simple repetitive sequences within the intron between exons 2 and 3 and hybridisation of selected oligonucleotides to polymorphisms within exon 2. Faecal samples were taken from 200 lambs from one to six months of age at intervals of 4 weeks. Genetic effects were strongest at 6 months of age. Least-squares analysis indicated that substitution of the most common allele (I) by allele G2 would result in a 58-fold reduction in faecal egg counts in 6-month-old lambs and a 22-fold reduction in 5-month-old lambs. These results suggest that the major histocompatibility complex plays an important role in the development of resistance to
O. circumcincta.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7558567</pmid><doi>10.1016/0020-7519(94)00216-B</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal for parasitology, 1995-07, Vol.25 (7), p.815-822 |
| issn | 0020-7519 1879-0135 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alleles Animals Base Sequence Biological and medical sciences disease association DNA Probes - genetics DRB-typing faecal egg count Feces - parasitology Female Helminthic diseases Infectious diseases Major Histocompatibility Complex Male Medical sciences MHC Miscellaneous Molecular Sequence Data Ostertagia circumcincta Ostertagiasis - genetics Ostertagiasis - immunology Ostertagiasis - veterinary Parasite Egg Count Parasitic diseases Sheep - genetics Sheep - immunology Sheep Diseases - genetics Sheep Diseases - immunology Sheep Diseases - parasitology |
| title | An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection |
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