PROPHYLACTIC EFFECTS OF CEFMENOXIME AGAINST POSTOPERATIVE INFECTIONS AFTER THORACOTOMY: STUDIES OF CEFMENOXIME TRANSFER FROM SERUM TO PLEURAL FLUID AND OF CLINICAL EFFECTS OF CEFMENOXIME
Cefmenoxime (CMX) at a dose of 1 g was administered intravenously to each of 10 patients undergoing thoracotomy, and concentrations of CMX in the serum and pleural fluid were measured. Serum concentration of CMX reached its peak of 43.71 μg/ml at 1 hour and decreased to 4.15 μg/ml at 3 hours after t...
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| Veröffentlicht in: | Japanese journal of antibiotics 1987/02/25, Vol.40(2), pp.295-302 |
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| container_title | Japanese journal of antibiotics |
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| creator | MATSUURA, YUICHIRO YAMASHINA, HIDEKI HIGO, MASANORI FUJII, TAKANORI YAMAMOTO, MASAHARU SHIMAMOTO, HIROYUKI |
| description | Cefmenoxime (CMX) at a dose of 1 g was administered intravenously to each of 10 patients undergoing thoracotomy, and concentrations of CMX in the serum and pleural fluid were measured. Serum concentration of CMX reached its peak of 43.71 μg/ml at 1 hour and decreased to 4.15 μg/ml at 3 hours after the administration. The concentration of CMX in the pleural fluid eached its peak of 7.61 μg/ml at 3 hours and decreased slowly 5.26 μg/ml at 7 hours after the administration. A clinical study with 21 patients was performed to evaluate the effect of CMX as a prophylactic antimicrobial agent in thoracotomy. Patients received intravenous administration of 4 g/day of CMX for 7-10 days following operations. Each patient was evaluated daily for fever, sign of allergic reaction, and wound infection and other symptoms. No apparent infection occured in those clinical patients except 1 patient with a suspected infection, and 1 case of allergic reaction as exanthema was observed during this study. Prophylactic effect of CMX against postoperative infection after thoracotomy was good. |
| doi_str_mv | 10.11553/antibiotics1968b.40.295 |
| format | Article |
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Serum concentration of CMX reached its peak of 43.71 μg/ml at 1 hour and decreased to 4.15 μg/ml at 3 hours after the administration. The concentration of CMX in the pleural fluid eached its peak of 7.61 μg/ml at 3 hours and decreased slowly 5.26 μg/ml at 7 hours after the administration. A clinical study with 21 patients was performed to evaluate the effect of CMX as a prophylactic antimicrobial agent in thoracotomy. Patients received intravenous administration of 4 g/day of CMX for 7-10 days following operations. Each patient was evaluated daily for fever, sign of allergic reaction, and wound infection and other symptoms. No apparent infection occured in those clinical patients except 1 patient with a suspected infection, and 1 case of allergic reaction as exanthema was observed during this study. Prophylactic effect of CMX against postoperative infection after thoracotomy was good.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.40.295</identifier><identifier>PMID: 3474428</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Aged ; Bacterial Infections - prevention & control ; Cefmenoxime ; Cefotaxime - administration & dosage ; Cefotaxime - analogs & derivatives ; Cefotaxime - metabolism ; Cefotaxime - therapeutic use ; Drug Evaluation ; Female ; Humans ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Pleural Effusion - metabolism ; Pneumothorax - surgery ; Postoperative Complications - prevention & control ; Premedication ; Thoracic Surgery</subject><ispartof>The Japanese Journal of Antibiotics, 1987/02/25, Vol.40(2), pp.295-302</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3474428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUURA, YUICHIRO</creatorcontrib><creatorcontrib>YAMASHINA, HIDEKI</creatorcontrib><creatorcontrib>HIGO, MASANORI</creatorcontrib><creatorcontrib>FUJII, TAKANORI</creatorcontrib><creatorcontrib>YAMAMOTO, MASAHARU</creatorcontrib><creatorcontrib>SHIMAMOTO, HIROYUKI</creatorcontrib><title>PROPHYLACTIC EFFECTS OF CEFMENOXIME AGAINST POSTOPERATIVE INFECTIONS AFTER THORACOTOMY: STUDIES OF CEFMENOXIME TRANSFER FROM SERUM TO PLEURAL FLUID AND OF CLINICAL EFFECTS OF CEFMENOXIME</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>Cefmenoxime (CMX) at a dose of 1 g was administered intravenously to each of 10 patients undergoing thoracotomy, and concentrations of CMX in the serum and pleural fluid were measured. Serum concentration of CMX reached its peak of 43.71 μg/ml at 1 hour and decreased to 4.15 μg/ml at 3 hours after the administration. The concentration of CMX in the pleural fluid eached its peak of 7.61 μg/ml at 3 hours and decreased slowly 5.26 μg/ml at 7 hours after the administration. A clinical study with 21 patients was performed to evaluate the effect of CMX as a prophylactic antimicrobial agent in thoracotomy. Patients received intravenous administration of 4 g/day of CMX for 7-10 days following operations. Each patient was evaluated daily for fever, sign of allergic reaction, and wound infection and other symptoms. No apparent infection occured in those clinical patients except 1 patient with a suspected infection, and 1 case of allergic reaction as exanthema was observed during this study. Prophylactic effect of CMX against postoperative infection after thoracotomy was good.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial Infections - prevention & control</subject><subject>Cefmenoxime</subject><subject>Cefotaxime - administration & dosage</subject><subject>Cefotaxime - analogs & derivatives</subject><subject>Cefotaxime - metabolism</subject><subject>Cefotaxime - therapeutic use</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pleural Effusion - metabolism</subject><subject>Pneumothorax - surgery</subject><subject>Postoperative Complications - prevention & control</subject><subject>Premedication</subject><subject>Thoracic Surgery</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1OwzAURi0EgqrwCEie2FJsx47tMYocGtTWVWsQTJHtuJCqfyTpwNtTaNWB5d7hHH3DAQBiNMCYsfjRbrra1duu9i2WiXADigZEsgvQI1gkEaOcX4IeihMRES7wDbhr29qhGHNBDgvX4DqmnFIieuB1OtPT4fsozUyRQZXnKjNzqHOYqXysJvqtGCuYPqXFZG7gVM-NnqpZaopXBYvJr1zoyRymuVEzaIZ6lmba6PH7Lbha2FUb7k6_D15yZbJhNNJPRZaOoiUWoovswjuRVNYzySu2QJgzFIJNGHaUJD7xxMmKeUckih3ivnKMIupERXCFpbBxHzwcd3fN9msf2q5c160Pq5XdhO2-LTlnnEoiD-L9Sdy7dajKXVOvbfNdnkIc-PORL9vOfoQzt82h8iqU_5OXFJXk70h2lvynbcqwiX8ALi94iA</recordid><startdate>198702</startdate><enddate>198702</enddate><creator>MATSUURA, YUICHIRO</creator><creator>YAMASHINA, HIDEKI</creator><creator>HIGO, MASANORI</creator><creator>FUJII, TAKANORI</creator><creator>YAMAMOTO, MASAHARU</creator><creator>SHIMAMOTO, HIROYUKI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198702</creationdate><title>PROPHYLACTIC EFFECTS OF CEFMENOXIME AGAINST POSTOPERATIVE INFECTIONS AFTER THORACOTOMY</title><author>MATSUURA, YUICHIRO ; YAMASHINA, HIDEKI ; HIGO, MASANORI ; FUJII, TAKANORI ; YAMAMOTO, MASAHARU ; SHIMAMOTO, HIROYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j188t-afcb86dac597d5f01750eea651b426c6c2b9d5cb2903b07cdb5404b8d21d198a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacterial Infections - prevention & control</topic><topic>Cefmenoxime</topic><topic>Cefotaxime - administration & dosage</topic><topic>Cefotaxime - analogs & derivatives</topic><topic>Cefotaxime - metabolism</topic><topic>Cefotaxime - therapeutic use</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pleural Effusion - metabolism</topic><topic>Pneumothorax - surgery</topic><topic>Postoperative Complications - prevention & control</topic><topic>Premedication</topic><topic>Thoracic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUURA, YUICHIRO</creatorcontrib><creatorcontrib>YAMASHINA, HIDEKI</creatorcontrib><creatorcontrib>HIGO, MASANORI</creatorcontrib><creatorcontrib>FUJII, TAKANORI</creatorcontrib><creatorcontrib>YAMAMOTO, MASAHARU</creatorcontrib><creatorcontrib>SHIMAMOTO, HIROYUKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUURA, YUICHIRO</au><au>YAMASHINA, HIDEKI</au><au>HIGO, MASANORI</au><au>FUJII, TAKANORI</au><au>YAMAMOTO, MASAHARU</au><au>SHIMAMOTO, HIROYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PROPHYLACTIC EFFECTS OF CEFMENOXIME AGAINST POSTOPERATIVE INFECTIONS AFTER THORACOTOMY: STUDIES OF CEFMENOXIME TRANSFER FROM SERUM TO PLEURAL FLUID AND OF CLINICAL EFFECTS OF CEFMENOXIME</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1987-02</date><risdate>1987</risdate><volume>40</volume><issue>2</issue><spage>295</spage><epage>302</epage><pages>295-302</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>Cefmenoxime (CMX) at a dose of 1 g was administered intravenously to each of 10 patients undergoing thoracotomy, and concentrations of CMX in the serum and pleural fluid were measured. Serum concentration of CMX reached its peak of 43.71 μg/ml at 1 hour and decreased to 4.15 μg/ml at 3 hours after the administration. The concentration of CMX in the pleural fluid eached its peak of 7.61 μg/ml at 3 hours and decreased slowly 5.26 μg/ml at 7 hours after the administration. A clinical study with 21 patients was performed to evaluate the effect of CMX as a prophylactic antimicrobial agent in thoracotomy. Patients received intravenous administration of 4 g/day of CMX for 7-10 days following operations. Each patient was evaluated daily for fever, sign of allergic reaction, and wound infection and other symptoms. No apparent infection occured in those clinical patients except 1 patient with a suspected infection, and 1 case of allergic reaction as exanthema was observed during this study. Prophylactic effect of CMX against postoperative infection after thoracotomy was good.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>3474428</pmid><doi>10.11553/antibiotics1968b.40.295</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1987/02/25, Vol.40(2), pp.295-302 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Bacterial Infections - prevention & control Cefmenoxime Cefotaxime - administration & dosage Cefotaxime - analogs & derivatives Cefotaxime - metabolism Cefotaxime - therapeutic use Drug Evaluation Female Humans Lung Neoplasms - surgery Male Middle Aged Pleural Effusion - metabolism Pneumothorax - surgery Postoperative Complications - prevention & control Premedication Thoracic Surgery |
| title | PROPHYLACTIC EFFECTS OF CEFMENOXIME AGAINST POSTOPERATIVE INFECTIONS AFTER THORACOTOMY: STUDIES OF CEFMENOXIME TRANSFER FROM SERUM TO PLEURAL FLUID AND OF CLINICAL EFFECTS OF CEFMENOXIME |
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