Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021

Purpose : The inflammatory process is likely involved in normal tissue damage after radiation exposure, yet few studies have directly evaluated the factors that might be involved in the regulation of inflammation after irradiation in vivo. We tested the hypothesis that platelet-activating factor, a...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1995-10, Vol.33 (3), p.627-633
Hauptverfasser:	Kimura, Hiroyuki, Wu, Ning Z., Dodge, Richard, Spencer, David P., Klitzman, Bruce M., McIntyre, Thomas M., Dewhirst, Mark W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological effects of radiation Cell Adhesion - drug effects Cell Adhesion - radiation effects Cell Communication - drug effects Cell Communication - radiation effects Diterpenes Endothelium, Vascular - drug effects Endothelium, Vascular - radiation effects Fibrinolytic Agents - pharmacology Fundamental and applied biological sciences. Psychology Ginkgolides Inflammation Ionizing radiations Lactones - pharmacology Leukocyte-endothelial cell interaction Leukocytes - drug effects Leukocytes - radiation effects Normal tissue Platelet-activating factor Radiation Random Allocation Rats Rats, Inbred F344 Tissues, organs and organisms biophysics Up-Regulation - drug effects Up-Regulation - radiation effects
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