Expression of cytokine receptors by human cord blood lymphocytes : comparison with adult blood lymphocytes
The expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels...
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| Veröffentlicht in: | Pediatric research 1995-09, Vol.38 (3), p.397-403 |
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| container_title | Pediatric research |
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| creator | ZOLA, H FUSCO, M MACARDLE, P. J FLEGO, L ROBERTON, D |
| description | The expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels of receptor measurable. Cord blood lymphocytes expressed measurable levels of most cytokine receptors, but expression tended to be lower than in adult blood cells. Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate. |
| doi_str_mv | 10.1203/00006450-199509000-00021 |
| format | Article |
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The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-199509000-00021</identifier><identifier>PMID: 7494666</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Antibodies, Monoclonal ; Biological and medical sciences ; Cells, Cultured ; Fetal Blood ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Infant, Newborn ; Interleukin-4 - pharmacology ; Lymphocyte Activation - drug effects ; Lymphocytes - immunology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Monocytes - immunology ; Phytohemagglutinins - pharmacology ; Receptors, Cytokine - analysis</subject><ispartof>Pediatric research, 1995-09, Vol.38 (3), p.397-403</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-bd67388153119e105c72f699a80892597f10b8eba847095ff24a935a9de05ad33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23921,23922,25131,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3629297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7494666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZOLA, H</creatorcontrib><creatorcontrib>FUSCO, M</creatorcontrib><creatorcontrib>MACARDLE, P. J</creatorcontrib><creatorcontrib>FLEGO, L</creatorcontrib><creatorcontrib>ROBERTON, D</creatorcontrib><title>Expression of cytokine receptors by human cord blood lymphocytes : comparison with adult blood lymphocytes</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>The expression of receptors for several cytokines (IL 2, IL-4, IL-6, IL-7, tumor necrosis factor, and interferon-gamma) was examined in human cord blood cells in comparison with adult blood cells. A previously described high sensitivity immunofluorescence procedure was used to render the low levels of receptor measurable. Cord blood lymphocytes expressed measurable levels of most cytokine receptors, but expression tended to be lower than in adult blood cells. Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.</description><subject>Adult</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Fetal Blood</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Infant, Newborn</subject><subject>Interleukin-4 - pharmacology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>Monocytes - immunology</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Receptors, Cytokine - analysis</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE9PxCAQxYnRrOvqRzDhYLxVoUABb2az_kk28aJnQilku7alQhvttxfddS-STMjk_d5M5gEAMbrBOSK3KL2CMpRhKRmSqctS5fgIzDEjqaGUH4M5QgRnREpxCs5i3CKEKRN0BmacSloUxRxsV199sDHWvoPeQTMN_r3uLAzW2H7wIcJygpux1R00PlSwbLyvYDO1_cYn2EZ4l4S216GOacRnPWygrsZm-E-egxOnm2gv9v8CvD2sXpdP2frl8Xl5v84MxWLIyqrgRIh0BsbSYsQMz10hpRZIyJxJ7jAqhS21oBxJ5lxOtSRMy8oipitCFuB6N7cP_mO0cVBtHY1tGt1ZP0bFOUtGLBIodqAJPsZgnepD3eowKYzUT8zqL2Z1iFn9xpysl_sdY9na6mDc55r0q72uo9GNC7ozdTxgpMhlLjn5Bi5oheM</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>ZOLA, H</creator><creator>FUSCO, M</creator><creator>MACARDLE, P. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Infant, Newborn</topic><topic>Interleukin-4 - pharmacology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</topic><topic>Monocytes - immunology</topic><topic>Phytohemagglutinins - pharmacology</topic><topic>Receptors, Cytokine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZOLA, H</creatorcontrib><creatorcontrib>FUSCO, M</creatorcontrib><creatorcontrib>MACARDLE, P. 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Examination of different lymphocyte subpopulations revealed a complex pattern with some cell types expressing particular receptors equivalent to adult levels. Cord and adult blood monocytes expressed similar cytokine receptor profiles. Receptor expression in cord lymphocytes could be regulated by activation. The results provide indications as to the relative activities of different cytokines in the development of the immune system in the neonate.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7494666</pmid><doi>10.1203/00006450-199509000-00021</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 1995-09, Vol.38 (3), p.397-403 |
| issn | 0031-3998 1530-0447 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Adult Antibodies, Monoclonal Biological and medical sciences Cells, Cultured Fetal Blood Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Infant, Newborn Interleukin-4 - pharmacology Lymphocyte Activation - drug effects Lymphocytes - immunology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Monocytes - immunology Phytohemagglutinins - pharmacology Receptors, Cytokine - analysis |
| title | Expression of cytokine receptors by human cord blood lymphocytes : comparison with adult blood lymphocytes |
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